Abstract:
:The influence of environmental (extracellular) pH on the sporulation rhythm in Neurospora crassa was investigated for wild-type (frq+) and the mutants chr, frq1, frq7, and frq8. In all mutants, including wild type, the growth rate was found to be influenced strongly by extracellular pH in the range 4-9. On the other hand, for the same pH range, the period length of the sporulation rhythm is little influenced in wild type, chr, and frq1. A loss of pH homeostasis of the period, however, was observed in the mutants frq7 and frq8, which also are known to have lost temperature compensation. Concerning the influence of extracellular pH on growth rates, a clear correspondence between growth rates and the concentration of available H2PO4- ion has been found, indicating that the uptake of H2PO4- may be a limiting factor for growth under our experimental conditions. The loss of pH compensation in the frq7 and frq8 mutants may be related to less easily degradable FRQ7,8 proteins when compared with wild-type FRQ. Results from recent model considerations and experimental results predict that, with increasing extra-and intracellular pH, the FRQ7 protein degradation increases and should lead to shorter period lengths.
journal_name
Chronobiol Intjournal_title
Chronobiology internationalauthors
Ruoff P,Behzadi A,Hauglid M,Vinsjevik M,Havås Hdoi
10.1081/cbi-100102109subject
Has Abstractpub_date
2000-11-01 00:00:00pages
733-50issue
6eissn
0742-0528issn
1525-6073journal_volume
17pub_type
杂志文章abstract::In previous experiments, we found that rats raised in constant light (LL) manifested a more robust circadian rhythm of motor activity in LL and showed longer phase shifts after a light pulse in constant darkness (DD) than chose raised under constant darkness. In addition, we observed that the effects produced by const...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-100106081
更新日期:2001-07-01 00:00:00
abstract::Bone sarcomatous cells derived from human malignant tumors were cultured. The mitotic index was recorded for 39 hr. When the cultured cells originated from patients with cancer disease before any chemotherapy, ultradian mitotic rhythms of a 6-9-hr period were detected, but in many cases only after a sensitive statisti...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528909064628
更新日期:1989-01-01 00:00:00
abstract::Chronic sympathetic denervation of the pineal gland by bilateral removal of the superior cervical ganglia (SCG) was performed on female rats 30 days before impregnation. The offspring, maintained in the dark from birth, had disruption of the malate dehydrogenase circadian rhythm in the testes at 25 days of age. A dail...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529509064495
更新日期:1995-02-01 00:00:00
abstract::Performance alterations in executive function have been studied as potential endophenotypes for several neuropsychiatric diseases. Planning is an important component of executive function and has been shown to be affected in diseases such as attention deficit hyperactivity disorder, schizophrenia, obsessive-compulsive...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2015.1014096
更新日期:2015-06-01 00:00:00
abstract::The effects of Chagas disease on the mammalian circadian system were studied in Trypanosoma cruzi-infected C57-B16J mice. Animals were inoculated with CAI or RA strains of T. cruzi or vehicle, parasitism confirmed by blood specimen visualization and locomotor activity rhythms analyzed by wheel-running recording. RA-st...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-120017687
更新日期:2003-01-01 00:00:00
abstract::Population multiple components is a statistical tool useful for the analysis of time-dependent hybrid data. With a small number of parameters, it is possible to model and to predict the periodic behavior of a population. In this article, we propose two methods to compare among populations rhythmometric parameters obta...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-120038630
更新日期:2004-05-01 00:00:00
abstract::Circadian phase dependency in pharmacokinetics and hemodynamic effects on blood pressure and heart rate of different galenic formulations of nifedipine (immediate-release, sustained-release, and i.v. solution) were studied in healthy subjects or in hypertensive patients. Pharmacokinetics of immediate-release but not s...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529109059184
更新日期:1991-01-01 00:00:00
abstract::A double-blind randomized parallel-group trial was undertaken to evaluate the influence of the dosing time of sustained-release ketoprofen (SRK) on its acceptability and efficacy. The SRK was prescribed for 2 weeks (200 mg once a day) to 117 outpatients with osteoarthritis of the knee and/or hip. One group received SR...
journal_title:Chronobiology international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/07420529409055898
更新日期:1994-04-01 00:00:00
abstract::Fatigue is an increasingly noted factor in road accidents. The ability to predict and be aware of impairment in terms of driving capability is important for potential legal liability and road safety. However, to date, there have been few studies that have investigated the accuracy of individuals in predicting how safe...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520601083391
更新日期:2006-01-01 00:00:00
abstract::Flexible working hours can have several meanings and can be arranged in a number of ways to suit the worker and/or employer. Two aspects of "flexible" arrangement of working hours were considered: one more subjected to company control and decision (variability) and one more connected to individual discretion and auton...
journal_title:Chronobiology international
pub_type: 杂志文章,多中心研究
doi:10.1080/07420520601087491
更新日期:2006-01-01 00:00:00
abstract::The 10 min psychomotor vigilance task (PVT) is commonly used in laboratory studies to assess the impact of sleep loss, sustained wakefulness, and/or time of day on neurobehavioral performance. In field settings, though, it may be impractical for participants to perform a test of this length. The aim of this study was ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520601067931
更新日期:2006-01-01 00:00:00
abstract::Twenty-two depressed subjects who met criteria for major depressive disorder were grouped according to their initial REM latency. Subjects with short (less than or equal to 60 min) initial REM latency were separated from those with normal (greater than 60 min) initial REM latency. Subjects with short initial REM laten...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529009056968
更新日期:1990-01-01 00:00:00
abstract::Night shiftworkers often complain of disturbed sleep during the day. This could be partly caused by morning sunlight exposure during the commute home, which tends to maintain the circadian clock on a daytime rhythm. The circadian clock is most sensitive to the blue portion of the visible spectrum, so our aim was to de...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520903044398
更新日期:2009-07-01 00:00:00
abstract::Although there are significant intra-individual differences in self-reported diurnal preference, as measured by validated questionnaires, the relative contribution of exogenous and endogenous factors to self-reported diurnal preference largely remains to be investigated. The present study examined which items from the...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520902820970
更新日期:2009-04-01 00:00:00
abstract::Changes in rectal temperature during mild exercise in the middle of the rising (11:00 h) and falling (23:00 h) phases of the circadian rhythm of resting core temperature have been compared. Seven healthy males were studied at rest, while exercising on a cycle ergometer (60 min at 80 W), and during the first 30 min of ...
journal_title:Chronobiology international
pub_type: 临床试验,杂志文章
doi:10.1080/07420520601142551
更新日期:2007-01-01 00:00:00
abstract::This retrospective study tested the hypothesis that disease control and treatment-related toxicity in patients undergoing high-dose radiotherapy (HDRT) for prostate cancer varies in a circadian manner. Patients with localized prostate adenocarcinoma receiving HDRT (median 78 Gy) to the prostate and involved seminal ve...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2015.1130049
更新日期:2016-01-01 00:00:00
abstract::The 3111T/C single nucleotide polymorphism (SNP) of Circadian Locomotor Output Cycles Kaput (CLOCK) gene reportedly affects gastric motility before breakfast. It is of interest to know whether this SNP can affect the motility during the daytime. We investigated the association between the CLOCK 3111T/C SNP and several...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2017.1373660
更新日期:2017-01-01 00:00:00
abstract::Long working hours have been associated with an increased risk of cardiovascular disease, but its relationship with hypertension remains unclear. The objective of this study is to examine the relationship between overtime and presence of hypertension using data from a large-scale multi-company study in Japan. Particip...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2014.957298
更新日期:2014-12-01 00:00:00
abstract::Appreciation of chronotherapy in hypertension continues to lag, despite clear demonstrations by many studies of (i) clinically relevant dosing-time differences of the beneficial and adverse effects of most blood pressure (BP) medications and (ii) significant association between reduced sleep-time BP decline of non-dip...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2010.510788
更新日期:2010-09-01 00:00:00
abstract::The regulation of genetic expression is tightly controlled and well balanced in the organism by different epigenetic mechanisms such as DNA methylation and histone modifications. DNA methylation occurring after embryogenesis is seen mainly as an irreversible event. Even small changes in genomic DNA methylation might b...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520701290565
更新日期:2007-01-01 00:00:00
abstract::The focus of this study was on daytime and nighttime sleep and wakefulness during the peak age for Sudden Infant Death Syndrome (SIDS), two to four months, to determine whether there are differences between at-risk for SIDS (R) and control (C) infants. Such differences may provide insight on the frequent occurrence of...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520600921070
更新日期:2006-01-01 00:00:00
abstract::Career decisions are based on the fit between an individual and his/her environment. This study explores the effect of person-environment fit regarding actual and preferred weekly working hours on early and late retirement intentions in a sample of 7,859 employees aged 50 to 65 years of age living in Germany. Findings...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2020.1806291
更新日期:2020-08-24 00:00:00
abstract::Shiftwork, particularly that including night work, causes disruption of biological rhythms and perturbation of the social and family life that can negatively affect performance efficiency, health, and social relations. Adverse effects can manifest themselves in the short term as sleep disturbances, shiftlag syndrome, ...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.3109/07420529709001147
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND:Patients with mood disorders show a high dependence of behavior on the molecular characteristics of the biological clock. CLOCK rs1801260 gene polymorphism influences circadian behavior in bipolar disorder (BD), with *C carriers showing a delayed sleep onset and worse insomnia. Sleep phase delay and insomnia...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2015.1060603
更新日期:2015-01-01 00:00:00
abstract::Circadian rhythms in mammals are driven by a central clock in the suprachiasmatic nucleus (SCN). In vitro, temperature cycles within the physiological range can act as potent entraining cues for biological clocks. We altered the body temperature (Tc) rhythm in rats by manipulating energy intake (EI) to determine wheth...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2015.1112395
更新日期:2016-01-01 00:00:00
abstract::In Cushing's syndrome, the cortisol rhythm is impaired and can be associated with the disruption in the rhythmic expression of clock genes. In this study, we evaluated the expression of CLOCK, BMAL1, CRY1, CRY2, PER1, PER2, PER3 genes in peripheral blood leukocytes of healthy individuals (n = 13) and Cushing's disease...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2020.1758126
更新日期:2020-06-01 00:00:00
abstract::Disruption of circadian rhythms, which frequently occurs during night shift work, may be associated with cancer progression. The effect of chronotype (preference for behaviors such as sleep, work, or exercise to occur at particular times of day, with an associated difference in circadian physiology) and alignment of b...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2013.842575
更新日期:2014-03-01 00:00:00
abstract::The construction of time-specified reference limits requires systematic sampling in clinical health, particularly for those variables characterized by a circadian rhythm of large amplitude, as it is the case for blood pressure (BP). For the detection of false negatives, tolerance intervals (limits that will include at...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-100101064
更新日期:2000-07-01 00:00:00
abstract::Using both previously published findings and entirely new data, we present evidence in support of the argument that the circadian dysfunction of advancing age in the healthy human is primarily one of failing to transduce the circadian signal from the circadian timing system (CTS) to rhythms "downstream" from the pacem...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-100101051
更新日期:2000-05-01 00:00:00
abstract::In mammals, non-visual responses to light involve intrinsically photosensitive melanopsin-expressing retinal ganglion cells (ipRGCs) that receive synaptic inputs from rod and cone photoreceptors. Several studies have shown that cones also play a role in light entrainment, photic responses of the suprachiasmatic nucleu...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420521003695704
更新日期:2010-06-01 00:00:00