Pharmacokinetics of single-dose administration of naproxen at 10:00 and 22:00 hours.

Abstract:

:The pharmacokinetics of naproxen was studied in 12 healthy male volunteers after a single oral dose of 500 mg at 10:00 and 22:00 h. Ingestion of drug at 22:00 h delayed the occurrence of peak serum levels (p < 0.0212). None of the other pharmacokinetic parameters exhibited any significant diurnal variations.

journal_name

Chronobiol Int

authors

Rao BR,Rambhau D,Rao VV

doi

10.3109/07420529309059703

subject

Has Abstract

pub_date

1993-04-01 00:00:00

pages

137-42

issue

2

eissn

0742-0528

issn

1525-6073

journal_volume

10

pub_type

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