Abstract:
:The pharmacokinetics of naproxen was studied in 12 healthy male volunteers after a single oral dose of 500 mg at 10:00 and 22:00 h. Ingestion of drug at 22:00 h delayed the occurrence of peak serum levels (p < 0.0212). None of the other pharmacokinetic parameters exhibited any significant diurnal variations.
journal_name
Chronobiol Intjournal_title
Chronobiology internationalauthors
Rao BR,Rambhau D,Rao VVdoi
10.3109/07420529309059703subject
Has Abstractpub_date
1993-04-01 00:00:00pages
137-42issue
2eissn
0742-0528issn
1525-6073journal_volume
10pub_type
杂志文章abstract::In this paper, a peptic ulcer is considered from the perspective that it is representative of a heterogeneous group of multifactorial determined or influenced disorders having a common pathomorphologic expression. This heterogeneity involves pathophysiological attributes, including both functional (including secretory...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.1080/07420528709078511
更新日期:1987-01-01 00:00:00
abstract::To compare the behavioral effects of sleep-loss sleepiness (performance impairment due to sleep loss) and sleep inertia (period of impaired performance that follows awakening), mean response latencies and number of lapses from a visual simple reaction-time task were analyzed. Three experimental conditions were designe...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520802397228
更新日期:2008-09-01 00:00:00
abstract::Workers who meet the criteria for shift work disorder (SWD) have elevated levels of risk for various health and behavioral problems. However, the impact of having SWD on shiftworkers engaged in rapid-rotation schedules is unknown. Moreover, the risk factors for the occurrence of SWD remain unclear. To clarify these is...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2012.762010
更新日期:2013-05-01 00:00:00
abstract::Postoperative delirium, a common perioperative complication, is frequently observed in elderly surgical patients. Few studies have investigated the life rhythm of preoperative patients, and whether or not the preoperative life rhythm is associated with the development of postoperative delirium. The purpose of this stu...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2020.1764012
更新日期:2020-07-01 00:00:00
abstract::The human sleep-wake cycle is characterized by significant individual differences. Those differences in the sleep-wake cycle are partially heritable but are also influenced by environmental factors like the light/dark cycle or social habits. In this study we analyse for the first time the sleep-wake rhythm of adolesce...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2012.741173
更新日期:2012-12-01 00:00:00
abstract::The rods in the retina are responsible for night vision, whereas the cone system enables day vision. We studied whether rod function in humans exhibits an endogenous circadian rhythm and if changes occur in conditions of prolonged darkness. Seven healthy subjects (mean age+/-SD: 25.6+/-12.3 yr) completed a 4.5-day pro...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520802689814
更新日期:2009-01-01 00:00:00
abstract::A double-blind randomized parallel-group trial was undertaken to evaluate the influence of the dosing time of sustained-release ketoprofen (SRK) on its acceptability and efficacy. The SRK was prescribed for 2 weeks (200 mg once a day) to 117 outpatients with osteoarthritis of the knee and/or hip. One group received SR...
journal_title:Chronobiology international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/07420529409055898
更新日期:1994-04-01 00:00:00
abstract::Fourteen ambulatory subjects, varying in their amount of habitual physical activity, were studied for 24 h during a total of 25 "typical" days. Rectal temperature was recorded every 6 minutes, an activity diary was filled in every half hour, and wrist activity and heart rate were monitored every minute. Actimetry and ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529908998721
更新日期:1999-07-01 00:00:00
abstract::Circadian rhythms are still expressed in animals that display daily torpor, implying a temperature compensation of the pacemaker. Nevertheless, it remains unclear how the clock works in hypothermic states and whether torpor itself, as a temperature pulse, affects the circadian system. To reveal changes in the clockwor...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520500522424
更新日期:2006-01-01 00:00:00
abstract::Time-dependent variations in the vasodilator effects of beta-adrenergic agonists terbutaline (Ter) and dobutamine (Dob) were studied in isolated rings of rat thoracic aorta in both endothelium-intact and endothelium-denuded preparations. Rats were housed in light from 08:00 to 20:00 and in darkness from 20:00 to 08:00...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529808998680
更新日期:1998-03-01 00:00:00
abstract::Previous studies have demonstrated seasonal variation in the incidence of acute myocardial infarction (AMI) with an increase in cases during the winter months. However, they did not assess whether ST-elevation MI (STEMI) and non-ST-elevation MI (NSTEMI) exhibit similar changes. The object of this study was to compare ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520701800611
更新日期:2007-01-01 00:00:00
abstract::The suprachiasmatic nucleus (SCN) of the hypothalamus is considered the master circadian oscillator in mammals. However, extra-SCN structures in the brain also display daily rhythms. Recently, we have demonstrated that the choroid plexus (CP) expresses core clock genes that are subjected to circadian regulation in a s...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2017.1400978
更新日期:2018-02-01 00:00:00
abstract::Our current 24-h society and the weekday-weekend switch of our social clocks may affect young children's sleep and circadian rhythms. However, such evidence is scarce. We conducted a nationwide epidemiological study of sleep and health in preschool children aged 3-5 years attending kindergarten or childcare centers in...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2016.1217231
更新日期:2016-01-01 00:00:00
abstract::The circadian system is organized in a hierarchy of multiple oscillators, with the suprachiasmatic nucleus (SCN) as the master oscillator in mammals. The SCN is formed by a group of coupled cell oscillators. Knowledge of this coupling mechanism is essential to understanding entrainment and the expression of circadian ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2017.1380658
更新日期:2018-01-01 00:00:00
abstract::Twenty-four different laboratory parameters including the phagocytic activity (phagocytic index) of polymorphonuclear leukocytes (PMNs) and various hematologic variables were investigated in 13 young healthy men during Spring 1988 in Munich, Germany. Venous blood of these volunteers was obtained under standardized con...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529209064514
更新日期:1992-01-01 00:00:00
abstract::Due to personal and working necessities, the time for exercise is often short, and scheduled early in the morning or late in the afternoon. Cortisol plays a central role in the physiological and behavioral response to a physical challenge and can be considered as an index of exercise stress. Therefore, the aim of this...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2017.1311336
更新日期:2017-01-01 00:00:00
abstract::The objectives of the study were to investigate the associations between night work and disability pension (DP) due to all causes, cardiovascular (CVD), mental, and other diagnoses, adjusting for familial confounding. The material of the study included comprehensive survey data on 27 165 Swedish twins born in 1935-195...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2017.1399137
更新日期:2018-02-01 00:00:00
abstract::ST8SIA2 and NCAM1 are functionally related genes forming polysialic acid (PSA) - neural cell adhesion molecule (NCAM) complex in suprachiasmatic nucleus (SCN), the regulating site of circadian biological rhythm. In this study, the relationship of ST8SIA2 and NCAM1 with circadian and seasonal rhythms of human behavior ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2017.1410827
更新日期:2018-03-01 00:00:00
abstract::Sleep and fatigue-associated symptoms are prominent during chemotherapy. The purpose of this pilot study was to examine bright light effects on sleep disruption, fatigue, daytime sleepiness, depression, and quality of life (QOL) in women with stage I-III breast cancer undergoing chemotherapy. In this 2-group randomize...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2021.1871914
更新日期:2021-01-21 00:00:00
abstract::One of the supposed mechanisms that may lead to breast cancer (BC) is an alteration of circadian gene expression and DNA methylation. We undertook an integrated approach to identify methylation pattern of core circadian promoter regions in BC patients with regard to clinical features. We performed a quantitative methy...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2019.1617732
更新日期:2019-08-01 00:00:00
abstract::Twenty-two depressed subjects who met criteria for major depressive disorder were grouped according to their initial REM latency. Subjects with short (less than or equal to 60 min) initial REM latency were separated from those with normal (greater than 60 min) initial REM latency. Subjects with short initial REM laten...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529009056968
更新日期:1990-01-01 00:00:00
abstract::The construction of time-specified reference limits requires systematic sampling in clinical health, particularly for those variables characterized by a circadian rhythm of large amplitude, as it is the case for blood pressure (BP). For the detection of false negatives, tolerance intervals (limits that will include at...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-100101064
更新日期:2000-07-01 00:00:00
abstract::Plasma triglyceride (TG) levels show a clear daily rhythm, however, thus far it is still unknown whether this rhythm results from a daily rhythm in TG production, TG uptake or both. Previous studies have shown that feeding activity affects plasma TG concentrations, but it is not clear how the daily rhythm in feeding a...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2018.1438456
更新日期:2018-07-01 00:00:00
abstract::In previous experiments, we found that rats raised in constant light (LL) manifested a more robust circadian rhythm of motor activity in LL and showed longer phase shifts after a light pulse in constant darkness (DD) than chose raised under constant darkness. In addition, we observed that the effects produced by const...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-100106081
更新日期:2001-07-01 00:00:00
abstract::In the current study, we studied behavioral patterns, such as foraging, activity, standing, and laying in a population of cattle wandering on streets of Raipur city. We also determined the effects of four environmental factors (temperature, humidity, light, and noise intensities) on these behaviors. We recorded all fo...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2019.1644345
更新日期:2019-10-01 00:00:00
abstract::Several substances change the period length of the circadian oscillator in the laminar pulvinus of Phaseolus coccineus L. if offered continuously via the transpiration stream to the isolated leaves in continuous light and constant temperature. The osmotica mannitol and PEG 6000 (polyethylene glycol) lengthen the circa...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528509055537
更新日期:1985-01-01 00:00:00
abstract::A physiological dose of orally administered melatonin shifts circadian rhythms in humans according to a phase-response curve (PRC) that is nearly opposite in phase with the PRCs for light exposure: melatonin delays circadian rhythms when administered in the morning and advances them when administered in the afternoon ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529209064550
更新日期:1992-10-01 00:00:00
abstract::Although chronic alcohol intake is associated with widespread disruptions of sleep-wake cycles and other daily biological rhythms in both human alcoholics and experimental animals, the extent to which the chronobiological effects of alcohol are mediated by effects on the underlying circadian pacemaker remains unknown....
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-200053496
更新日期:2005-01-01 00:00:00
abstract::Multiple components of the circadian central clock are phosphoproteins, and it has become increasingly clear that posttranslational modification is an important regulator of circadian rhythm in diverse organisms, from dinoflagellates to humans. Genetic studies in Drosophila have identified double-time (dbt), a serine/...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.1081/cbi-100103963
更新日期:2001-05-01 00:00:00
abstract::In young healthy subjects salmon calcitonin (SCT), intranasally administered, increased in serum as a function of the drug administration time. The serum concentration of a 400 IU SCT dose monitored 10 min after dosing was statistically more significant when inhaled at 0000 than at other, more conventional, administra...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528809079555
更新日期:1988-01-01 00:00:00