Abstract:
:In 24h studies of bone marrow (BM), circadian stage-dependent variations were demonstrated in the proliferative activity of BM cells from subsets of 35 healthy diurnally active men. On an average, the percentage of total BM cells in deoxyribonucleic acid (DNA) synthesis phase was 188% greater at midday than at midnight (circadian rhythm: p = 0.018; acrophase or peak time of 13: 16h). Patients with malignant disease (n = 15) and a normal cortisol circadian rhythm showed higher fractions of BM cells in S-phase at midday. Colony-forming units--granulocyte/macrophage (CFU-GM), an indicator of myeloid progenitor cells, showed the same circadian variation as DNA S-phase (average range of change or ROC = 136%; circadian rhythm: p < 0.001; acrophase of 12:09h). Deoxyribonucleic acid S-phase and CFU-GM in BM both showed a circannual rhythm (p = 0.015 and 0.008) with an identical acrophase of August 12. The daily peak in BM glutathione content, a tripeptide involved in cellular defense against cytotoxic damage, preceded BM proliferative peaks by 4-5 h (ROC = 31-90%; circadian rhythm: p = 0.05; acrophase of 08:30h). Myeloid (ROC = 57%; circadian rhythm: p = 0.056; acrophase at 08:40h) and erythroid (ROC = 26%; circadian rhythm: p = 0.01; acrophase of 13:01h) precursor cells were positively correlated (r = 0.41; p < 0.001), indicating a circadian temporal relationship and equal influence on S-phase of total BM cells. Yield of positive selected CD34+ progenitor stem cells also showed significant circadian variation (ROC = 595%; circadian rhythm: p = 0.02; acrophase of 12:40h). Thus, the temporal synchrony in cell cycling renders BM cells more sensitive at specific times to hematopoietic growth factors and cell cycle-specific cytotoxic drugs. Moreover, proper timing of BM harvesting may improve progenitor cell yield. When using marker rhythms in the blood to allow for individualized timing of BM procedures, the times of low values in white blood corpuscles, neutrophils, and lymphocytes and high values in cortisol were predictive of the times of highest BM erythroid, myeloid, and total S-phase numbers occurring in the following 12 h.
journal_name
Chronobiol Intjournal_title
Chronobiology internationalauthors
Smaaland R,Sothern RB,Laerum OD,Abrahamsen JFdoi
10.1081/cbi-120002594subject
Has Abstractpub_date
2002-01-01 00:00:00pages
101-27issue
1eissn
0742-0528issn
1525-6073journal_volume
19pub_type
杂志文章,评审abstract::A synopsis of the effects of exercise on the circadian system in nocturnal rodents is followed by a review of the few studies investigating the influence of exercise on the human circadian system. It is premature to make specific recommendations about using exercise to promote synchronization in people because of the ...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.3109/07420529709001157
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abstract::Genetic analysis of Neurospora crassa has identified many mutants that affect the biological clock. In this article we review the cloning of two of these genes, frq and prd-4. Both genes were isolated using a chromosome walk technique. Subcloning experiments and subsequent Northern analysis of frq implicate the import...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
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journal_title:Chronobiology international
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abstract::The avian circadian system is composed of the retina, the mammalian homolog region of the suprachiasmatic nucleus (SNC), and the pineal gland. The retina, itself, displays many rhythmic physiological events, such as movements of photoreceptor cells, opsin expression, retinal reisomerization, and melatonin and dopamine...
journal_title:Chronobiology international
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abstract::One of the supposed mechanisms that may lead to breast cancer (BC) is an alteration of circadian gene expression and DNA methylation. We undertook an integrated approach to identify methylation pattern of core circadian promoter regions in BC patients with regard to clinical features. We performed a quantitative methy...
journal_title:Chronobiology international
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journal_title:Chronobiology international
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journal_title:Chronobiology international
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journal_title:Chronobiology international
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abstract::Stress is associated with significant losses in the swine industry. Seasonal changes have been shown to affect stress resistance in several species of animals. In the present study, we examined the effect of two seasons (fall or winter) on plasma insulin, cortisol, and adrenocorticotrophin hormone (ACTH) levels from f...
journal_title:Chronobiology international
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journal_title:Chronobiology international
pub_type: 杂志文章
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journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528809079555
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abstract::The ventromedial hypothalamic nucleus (VMH) regulates various autonomic, endocrine, and behavioral activities. These activities show annual changes, and the pineal gland is involved in their adjustment to environmental cues. Therefore, this study investigated whether the VMH belongs to the effector structures of the p...
journal_title:Chronobiology international
pub_type: 杂志文章
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abstract::The electronic health record (EHR) contains rich histories of clinical care, but has not traditionally been mined for information related to sleep habits. Here, we performed a retrospective EHR study based on a cohort of 3,652 individuals with self-reported sleep behaviors documented from visits to the sleep clinic. T...
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journal_title:Chronobiology international
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journal_title:Chronobiology international
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journal_title:Chronobiology international
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journal_title:Chronobiology international
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journal_title:Chronobiology international
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journal_title:Chronobiology international
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abstract::During a 7-10 day span, circadian rhythms of sleep-wake, self-rated fatigue and mood, oral temperature, eye-hand skill and right and left hand grip strength were investigated in eight subjects: five males (21-28 years of age), members of the French sabre fencing team selected for the 1984 Olympic Games in Los Angeles,...
journal_title:Chronobiology international
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journal_title:Chronobiology international
pub_type: 杂志文章
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journal_title:Chronobiology international
pub_type: 杂志文章,评审
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journal_title:Chronobiology international
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journal_title:Chronobiology international
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journal_title:Chronobiology international
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journal_title:Chronobiology international
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journal_title:Chronobiology international
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