Abstract:
:Genetic analysis of Neurospora crassa has identified many mutants that affect the biological clock. In this article we review the cloning of two of these genes, frq and prd-4. Both genes were isolated using a chromosome walk technique. Subcloning experiments and subsequent Northern analysis of frq implicate the importance of two transcripts that emanate from this locus. In preliminary data, no protein-coding region is evident in the smaller transcript; the larger transcript contains a 962-amino acid open reading frame. The open reading frame shows limited homology to per, a clock gene identified in Drosophila. Sequence analysis of all existing frq alleles suggests that the defect in each case lies within the open reading frame. Successful cloning of the prd-4 gene required walking a distance of greater than 40 kb. A physical map of this region has been constructed using restriction analysis. The dominance-recessive relationship of prd-4 and prd-4+ was established by examining the period lengths of strains harboring a wide range of prd-4/prd-4+ nuclear ratios.
journal_name
Chronobiol Intjournal_title
Chronobiology internationalauthors
Aronson BD,Johnson KA,Liu Q,Dunlap JCdoi
10.3109/07420529209064532subject
Has Abstractpub_date
1992-06-01 00:00:00pages
231-9issue
3eissn
0742-0528issn
1525-6073journal_volume
9pub_type
杂志文章,评审abstract::Sleep-wake regulation involves reciprocal interactions between sleep- and wake-promoting processes that inhibit one another. To uncover the signatures of the opponent processes underlying ultradian sleep cycles, principal component analysis was performed on the sets of 16 single-Hz log-transformed electroencephalograp...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2011.565136
更新日期:2011-05-01 00:00:00
abstract::The aim of this study was to determine the relationship between pilot workload, performance, subjective fatigue, sleep duration, number of sectors and flight duration during short-haul operations. Ninety pilots completed a NASA Task Load Index, Psychomotor Vigilance Task and a Samn-Perelli fatigue scale on top-of-desc...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2020.1804924
更新日期:2020-08-24 00:00:00
abstract::Seasonal Affective Disorder (SAD) is a condition of regularly occurring depressions in winter with a remission the following spring or summer. In addition to depressed mood, the patients tend to experience increased appetite and an increased duration of sleep during the winter. SAD is a relatively common condition, af...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.1081/cbi-120019310
更新日期:2003-03-01 00:00:00
abstract::Eight diurnally active (approximately 0730-1100 hr) adults (41-61 yr) suffering from nocturnal asthma volunteered for a double-blind, cross-over randomized study of a once-daily dosing (600-900 mg/24 hr) of Armophylline (Rorer s.a., France), a sustained-release theophylline given either at 0800 hr or 2000 hr for 8-day...
journal_title:Chronobiology international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/07420528709083530
更新日期:1987-01-01 00:00:00
abstract::Despite research indicating that sleep disorders influence reproductive health, the effects of sleep on reproductive hormone concentrations are poorly characterized. We prospectively followed 259 regularly menstruating women across one to two menstrual cycles (the BioCycle Study, 2005-2007), measuring fasting serum ho...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2019.1694938
更新日期:2020-02-01 00:00:00
abstract::Daily schedules of many organisms, including birds, are thought to affect fitness. Timing in birds is based on circadian clocks that have a heritable period length, but fitness consequences for individuals in natural environments depend on the scheduling of entrained clocks. This chronotype, i.e., timing of an individ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2012.707159
更新日期:2012-10-01 00:00:00
abstract::A synopsis of the effects of exercise on the circadian system in nocturnal rodents is followed by a review of the few studies investigating the influence of exercise on the human circadian system. It is premature to make specific recommendations about using exercise to promote synchronization in people because of the ...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.3109/07420529709001157
更新日期:1997-03-01 00:00:00
abstract::Data on sleep or circadian abnormalities and metabolic disturbances in euthymic bipolar disorders are scarce and based on small sample sizes. The aim of this study was to explore the associations between sleep disturbances, chronotype and metabolic components in a large sample of euthymic patients with bipolar disorde...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2017.1332071
更新日期:2017-01-01 00:00:00
abstract::Flexible working hours can have several meanings and can be arranged in a number of ways to suit the worker and/or employer. Two aspects of "flexible" arrangement of working hours were considered: one more subjected to company control and decision (variability) and one more connected to individual discretion and auton...
journal_title:Chronobiology international
pub_type: 杂志文章,多中心研究
doi:10.1080/07420520601087491
更新日期:2006-01-01 00:00:00
abstract::In 33 patients with heart failure (NYHA II-III), the 24-h blood pressure rhythm was examined before and after the titration period of two ACE inhibitors. Blood pressure was measured by the oscillometric method using the blood pressure monitor 90202 from SpaceLabs, Inc. The measurements were taken from 06:00 to 22:00 h...
journal_title:Chronobiology international
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1991-01-01 00:00:00
abstract::Sleep-related problems, such as symptoms of insomnia, daytime sleepiness, shorter sleep duration, or a delayed sleep-wake schedule, are known to be risk factors for depression. In general, depression is more prevalent in women than in men, but sleep-related problems do not necessarily show similar gender predominance....
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2015.1055756
更新日期:2015-01-01 00:00:00
abstract::Light and temperature cycles are the most important synchronizers of biological rhythms in nature. However, the relative importance of each, especially when they are not in phase, has been poorly studied. The aim of this study was to analyze the entrainment of daily locomotor activity to light and/or temperature cycle...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520600651065
更新日期:2006-01-01 00:00:00
abstract::Circadian rhythms in plants are liable to masking, i.e. alterations by environmental influencing agents. Experiments have been reported for both positive and negative masking, attributed to a Zeitgeber which may either increase or decrease the amplitude of a circadian rhythm (CR). In some instances, the CR may even be...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528909059138
更新日期:1989-01-01 00:00:00
abstract::One of the supposed mechanisms that may lead to breast cancer (BC) is an alteration of circadian gene expression and DNA methylation. We undertook an integrated approach to identify methylation pattern of core circadian promoter regions in BC patients with regard to clinical features. We performed a quantitative methy...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2019.1617732
更新日期:2019-08-01 00:00:00
abstract::The regulation of genetic expression is tightly controlled and well balanced in the organism by different epigenetic mechanisms such as DNA methylation and histone modifications. DNA methylation occurring after embryogenesis is seen mainly as an irreversible event. Even small changes in genomic DNA methylation might b...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520701290565
更新日期:2007-01-01 00:00:00
abstract::Two different medications, one assumed to be a tranquilizer and the other an antifatigue agent, were tested. Both were found to be ineffective and thus were viewed as placebos and named P1 and P2. The effect of P1 and P2 on the circadian rhythms of a set of variables (e.g., sleep/wake, oral temperature and grip streng...
journal_title:Chronobiology international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/07420529409057230
更新日期:1994-02-01 00:00:00
abstract::The objectives of the study were to investigate the associations between night work and disability pension (DP) due to all causes, cardiovascular (CVD), mental, and other diagnoses, adjusting for familial confounding. The material of the study included comprehensive survey data on 27 165 Swedish twins born in 1935-195...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2017.1399137
更新日期:2018-02-01 00:00:00
abstract::Intolerance to shift work may result from individual susceptibility to an internal desynchronization. Some shift workers (SW) who show desynchronization of their circadian rhythms (e.g., sleep-wake, body temperature, and grip strength of both hands) exhibit symptoms of SW intolerance, such as sleep alteration, persist...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520802256101
更新日期:2008-07-01 00:00:00
abstract::In situ growth of Sphagnum riparium Ångstr. shoots were monitored during the 2015 and 2016 growing seasons in Karelia, Russia. It was established that shoot growth rates fluctuated with a period of around 30 days, that is, showed a circatrigintan rhythm. Such rhythms from mosses have not been previously reported. Corr...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2017.1329208
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journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520701531166
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journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2017.1325896
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journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2012.741169
更新日期:2013-05-01 00:00:00
abstract::Physiological and biomechanical constraints as well as their fluctuations throughout the day must be considered when studying determinant factors in the preferred pedaling rate of elite cyclists. The aim of this study was to monitor the diurnal variation of spontaneous pedaling rate and movement kinematics over the cr...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-120024220
更新日期:2003-09-01 00:00:00
abstract::Plasma triglyceride (TG) levels show a clear daily rhythm, however, thus far it is still unknown whether this rhythm results from a daily rhythm in TG production, TG uptake or both. Previous studies have shown that feeding activity affects plasma TG concentrations, but it is not clear how the daily rhythm in feeding a...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2018.1438456
更新日期:2018-07-01 00:00:00
abstract::Thermoregulatory processes have long been implicated in the initiation of human sleep. In this paper, we review our own studies conducted over the last decade showing a crucial role for melatonin as a mediator between the thermoregulatory and arousal system in humans. Distal heat loss, via increased skin temperature, ...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.1080/07420520500545854
更新日期:2006-01-01 00:00:00
abstract::Fourteen healthy subjects have been studied in an isolation unit while living on a 30h "day" (20h awake, 10h asleep) for 14 (solar) days but while aware of real time. Waking activities were sedentary and included reading, watching television, and so forth. Throughout, regular recordings of rectal temperature were made...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529609020906
更新日期:1996-10-01 00:00:00
abstract::The aim of the study was to evaluate the influence of chronotype (morning-type versus evening-type) living in a fixed sleep-wake schedule different from one's preferred sleep schedules on the time course of neurobehavioral performance during controlled extended wakefulness. The authors studied 9 morning-type and 9 eve...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2011.590623
更新日期:2011-07-01 00:00:00
abstract::In previous research, it was determined that the altitude of origin altered the parameters of photic entrainment and free-running rhythmicity of adult locomotor activity of the high-altitude Himalayan (haH) strain (Hemkund-Sahib, 4121 m above sea level) of Drosophila helvetica compared to the low-altitude Himalayan (l...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520701649448
更新日期:2007-01-01 00:00:00
abstract::Most research papers published in Chronobiology International report the findings of investigations conducted on laboratory animals and human beings. The Journal, its editors and the publication committee endorse the compliance of investigators to the principles of the Declaration of Helsinki of the World Medical Asso...
journal_title:Chronobiology international
pub_type: 杂志文章
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更新日期:2004-01-01 00:00:00
abstract::Coenzyme Q10 (CoQ10) or ubiquinone, a redox component of the mitochondrial electron transport chains, is a powerful antioxidant and membrane stabilizer that may prevent cellular damage during myocardial ischemia and reperfusion therapy. Coenzyme Q10 has been used primarily as an adjuvant therapy for some cardiomyopath...
journal_title:Chronobiology international
pub_type: 杂志文章
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更新日期:2002-05-01 00:00:00