Abstract:
:Seasonal Affective Disorder (SAD) is a condition of regularly occurring depressions in winter with a remission the following spring or summer. In addition to depressed mood, the patients tend to experience increased appetite and an increased duration of sleep during the winter. SAD is a relatively common condition, affecting 1-3% of adults in temperate climates, and it is more prevalent in women. The pathological mechanisms underlying SAD are incompletely understood. Certain neurotransmitters have been implicated; a dysfunction in the serotonin system in particular has been demonstrated by a variety of approaches. The role of circadian rhythms in SAD needs to be clarified. The phase-delay hypothesis holds that SAD patients' circadian rhythms are delayed relative to the sleep/wake or rest/activity cycle. This hypothesis predicts that the symptoms of SAD will improve if the circadian rhythms can be phase-advanced. There is some experimental support for this. SAD can be treated successfully with light therapy. In classical light therapy, the SAD sufferer sits in front of a light box, exposed to 2000-10,000 lux for 30-120 min daily during the winter. Other forms of light treatments, pharmacotherapy, and other therapies are currently being tested for SAD.
journal_name
Chronobiol Intjournal_title
Chronobiology internationalauthors
Magnusson A,Boivin Ddoi
10.1081/cbi-120019310subject
Has Abstractpub_date
2003-03-01 00:00:00pages
189-207issue
2eissn
0742-0528issn
1525-6073journal_volume
20pub_type
杂志文章,评审abstract::Sleep-wake regulation involves reciprocal interactions between sleep- and wake-promoting processes that inhibit one another. To uncover the signatures of the opponent processes underlying ultradian sleep cycles, principal component analysis was performed on the sets of 16 single-Hz log-transformed electroencephalograp...
journal_title:Chronobiology international
pub_type: 杂志文章
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journal_title:Chronobiology international
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journal_title:Chronobiology international
pub_type: 杂志文章,随机对照试验
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journal_title:Chronobiology international
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Chronobiology international
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journal_title:Chronobiology international
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journal_title:Chronobiology international
pub_type: 杂志文章
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journal_title:Chronobiology international
pub_type: 杂志文章
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journal_title:Chronobiology international
pub_type: 杂志文章
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journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2018.1443118
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journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-120006083
更新日期:2002-07-01 00:00:00
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journal_title:Chronobiology international
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journal_title:Chronobiology international
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journal_title:Chronobiology international
pub_type: 杂志文章
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journal_title:Chronobiology international
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journal_title:Chronobiology international
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journal_title:Chronobiology international
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