Abstract:
:Serious adverse cardiovascular events, including myocardial infarction, sudden cardiac death, and stroke, frequently result from rupture of atherosclerotic plaques with superimposed thrombosis and exhibit a pronounced circadian rhythmicity, peaking in the morning hours. Two potentially synergistic mechanisms play a pathogenic role in the circadian variation of arterial thrombotic events. A morning surge in sympathetic activity alters hemodynamic forces and predisposes vulnerable coronary atherosclerotic plaques to rupture. Day-night variations of hemostatic and fibrinolytic factors result in morning hypercoagulability and hypofibrinolysis, promoting intraluminal thrombus formation at the same time when the risk for plaque rupture is highest. Diabetic patients have a very high cardiac event rate but fail to show normal circadian fluctuations in the occurrence of myocardial infarction. Alterations in the circadian variation autonomic tone, blood pressure, and the thrombotic-thrombolytic equilibrium have been documented in diabetic patients. These include reduced or absent 24-h periodicity in autonomic tone, fibrinolytic activity, and thrombotic tendency, and a blunted decline in nocturnal blood pressure. Disruption of these circadian rhythms explains the lack of significant circadian distribution of cardiac events in diabetic patients. Moreover, the loss of these normal biorhythms results in a continuous susceptibility to thrombotic events throughout the day and may contribute to the excess cardiovascular mortality and morbidity in these patients.
journal_name
Chronobiol Intjournal_title
Chronobiology internationalauthors
Aronson Ddoi
10.1081/cbi-100001175subject
Has Abstractpub_date
2001-01-01 00:00:00pages
109-21issue
1eissn
0742-0528issn
1525-6073journal_volume
18pub_type
杂志文章,评审abstract::Although there are significant intra-individual differences in self-reported diurnal preference, as measured by validated questionnaires, the relative contribution of exogenous and endogenous factors to self-reported diurnal preference largely remains to be investigated. The present study examined which items from the...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520902820970
更新日期:2009-04-01 00:00:00
abstract::The circadian system is organized in a hierarchy of multiple oscillators, with the suprachiasmatic nucleus (SCN) as the master oscillator in mammals. The SCN is formed by a group of coupled cell oscillators. Knowledge of this coupling mechanism is essential to understanding entrainment and the expression of circadian ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2017.1380658
更新日期:2018-01-01 00:00:00
abstract::The aim of this study was to demonstrate that a possible recurrence may pertain to migraine attacks (MAs). The study was carried out by checking the personal diaries of 30 migraine sufferers ("migraineurs") who carefully annotated the date of their MA over twelve consecutive months. The group was composed of 15 males ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529009059158
更新日期:1990-01-01 00:00:00
abstract::Hyperphosphatemia is a common complication of chronic kidney disease (CKD) and is associated with cardiovascular disease (CVD), which has contributed to an increase in mortality of CKD patients. The onset of CVD often varies by time-of-day. Acute myocardial infarction or ventricular arrhythmia occurs most frequently d...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2018.1486850
更新日期:2018-09-01 00:00:00
abstract::Circadian rhythms are still expressed in animals that display daily torpor, implying a temperature compensation of the pacemaker. Nevertheless, it remains unclear how the clock works in hypothermic states and whether torpor itself, as a temperature pulse, affects the circadian system. To reveal changes in the clockwor...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520500522424
更新日期:2006-01-01 00:00:00
abstract::In birds, circadian control of tissue level communication is not well understood. The present study investigated this, by monitoring daily oscillation of genes coding for peptides (neuropeptide Y, NPY; vasoactive intestinal peptide, VIP; somatostatis, SST) and intermediary enzymes of amine and amino acid neurotransmit...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2016.1139587
更新日期:2016-01-01 00:00:00
abstract::In previous experiments, we found that rats raised in constant light (LL) manifested a more robust circadian rhythm of motor activity in LL and showed longer phase shifts after a light pulse in constant darkness (DD) than chose raised under constant darkness. In addition, we observed that the effects produced by const...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-100106081
更新日期:2001-07-01 00:00:00
abstract::We evaluated their circadian rhythms using data from electrocardiographic records and examined the change in circadian period related to normal RR intervals for astronauts who completed a long-term (≥6-month) mission in space. The examinees were seven astronauts, five men and two women, from 2009 to 2010. Their mean ±...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2014.979940
更新日期:2015-04-01 00:00:00
abstract::In 24h studies of bone marrow (BM), circadian stage-dependent variations were demonstrated in the proliferative activity of BM cells from subsets of 35 healthy diurnally active men. On an average, the percentage of total BM cells in deoxyribonucleic acid (DNA) synthesis phase was 188% greater at midday than at midnigh...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.1081/cbi-120002594
更新日期:2002-01-01 00:00:00
abstract::It was previously shown that there is seasonality in the amount of dietary carbohydrate not absorbed from the intestine after breakfast, the amount of carbohydrate in winter being significantly larger than that in autumn in young Japanese subjects. In order to investigate this phenomenon further, the experiment was re...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520701531166
更新日期:2007-01-01 00:00:00
abstract::Changes in the free-running period of the circadian rhythms of hamsters occur after single nonphotic events such as a 3-h pulse of running induced by being put in a novel wheel. These changes are mostly in the direction of longer periods, and can exceed 0.2 h; the magnitude of the effect depends on the circadian phase...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529309059709
更新日期:1993-08-01 00:00:00
abstract::Shift workers are known to have an increased risk of developing cardiovascular disease (CVD) compared with day workers. An important factor contributing to this increased risk could be the increased incidence of postprandial metabolic risk factors for CVD among shift workers, as a consequence of the maladaptation of e...
journal_title:Chronobiology international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1081/cbi-200037171
更新日期:2004-01-01 00:00:00
abstract::We analyzed the association between change in work schedule and modifications in nutritional status. We performed a panel study with nursing professionals based on two surveys seven year apart (n = 372). Groups with no change in work schedule, change from daytime to night shift, and change from night to daytime shift ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2016.1167719
更新日期:2016-01-01 00:00:00
abstract::Groups of photorefractory female subtropical house sparrows, Passer domesticus, when treated with 6 weeks of a short photocycle (8L:16D) showed significant ovarian growth on their return to a long photocycle (15L:9D). A 6-hr photophase coupled with scotophase of varying durations does not terminate the refractory peri...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529009056974
更新日期:1990-01-01 00:00:00
abstract::Julien-Joseph Virey (1775-1846) held the position of pharmacist-in-chief at the Val-de-Grâce, a military hospital. He was an innovative pharmacist, naturalist, anthropologist, and philosopher and a prolific author. His writings encompassed a wide range of topics, although many of his ideas were sometimes harshly quest...
journal_title:Chronobiology international
pub_type: 传,历史文章,杂志文章
doi:10.1081/cbi-100103184
更新日期:2001-03-01 00:00:00
abstract::Eveningness has been suggested as a facilitating factor in adaptation to shift work, with several studies reporting evening chronotypes (E-types) as better sleepers when on night shifts. Conversely, eveningness has been associated with more sleep complaints during day shifts. However, sleep during day shifts has recei...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2015.1033425
更新日期:2015-06-01 00:00:00
abstract::Previous literature suggests that human behaviour and physiology are somehow altered by the moon-cycle, with particular emphasis on poorer sleep quality and increased aggressive behaviour during full moon. The latter variables can negatively impact athletes' recovery and increase the likelihood of injury resulting fro...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2018.1483943
更新日期:2018-09-01 00:00:00
abstract::Bone sarcomatous cells derived from human malignant tumors were cultured. The mitotic index was recorded for 39 hr. When the cultured cells originated from patients with cancer disease before any chemotherapy, ultradian mitotic rhythms of a 6-9-hr period were detected, but in many cases only after a sensitive statisti...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528909064628
更新日期:1989-01-01 00:00:00
abstract::Previously, we have demonstrated the postembryonic development of chicken (Gallus gallus domesticus L.) pineal gland functions expressed as changes in melatonin (MEL) biosynthesis. Pineal concentrations of MEL and its precursor serotonin (5-HT) were shown to increase between the 2nd and 16th day of life. We also found...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2014.955185
更新日期:2015-02-01 00:00:00
abstract::Sleep-wake regulation involves reciprocal interactions between sleep- and wake-promoting processes that inhibit one another. To uncover the signatures of the opponent processes underlying ultradian sleep cycles, principal component analysis was performed on the sets of 16 single-Hz log-transformed electroencephalograp...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2011.565136
更新日期:2011-05-01 00:00:00
abstract::The appropriate time and place for sleep and waking are important factors for survival. Sleep and waking, rest and activity, flight and fight, feeding, and reproduction are all organized in relation to the day and night. A biological clock, the suprachiasmatic nucleus (SCN), synchronized by photic influences and other...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.1080/07420520500545961
更新日期:2006-01-01 00:00:00
abstract::Night work has emerged as a risk factor for many chronic diseases, including obesity, diabetes, and cardiovascular disease. While night work is linked to a number of cardiometabolic indices, few studies have explored how different parameters, such as cumulative night work and intensity of night work, may influence car...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2019.1570247
更新日期:2019-05-01 00:00:00
abstract::Specific binding of [3H]-imipramine in the rat suprachiasmatic nuclei, occipital cortex and caudate putamen underwent significant and replicable changes throughout 24 hr under a light-dark cycle or under constant conditions. Daily variations were also found in the medial and dorsal raphe nuclei and the lateral hypotha...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528609066357
更新日期:1986-01-01 00:00:00
abstract::Circadian rhythmicity of the structural morphometric model of rat endocrine pancreas has been studied in 24 Wistar female rats, four months old, kept in LD 12:12. The following parameters were evaluated: the volume fractions of nucleus and cytoplasm of exocrine cells, the size distribution and number in unit tissue vo...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529009059148
更新日期:1990-01-01 00:00:00
abstract::Seasonal variations have been described in humans in several variables such as sleep, mood, appetite, food preferences, or body weight. We hypothesized that these variations could also influence the decrease in body weight rate in patients submitted to body weight loss interventions. Thus, here we tested the variation...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2019.1580716
更新日期:2019-05-01 00:00:00
abstract::The avian circadian system is composed of the retina, the mammalian homolog region of the suprachiasmatic nucleus (SNC), and the pineal gland. The retina, itself, displays many rhythmic physiological events, such as movements of photoreceptor cells, opsin expression, retinal reisomerization, and melatonin and dopamine...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2010.540685
更新日期:2011-03-01 00:00:00
abstract::The regulation of genetic expression is tightly controlled and well balanced in the organism by different epigenetic mechanisms such as DNA methylation and histone modifications. DNA methylation occurring after embryogenesis is seen mainly as an irreversible event. Even small changes in genomic DNA methylation might b...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520701290565
更新日期:2007-01-01 00:00:00
abstract::ST8SIA2 and NCAM1 are functionally related genes forming polysialic acid (PSA) - neural cell adhesion molecule (NCAM) complex in suprachiasmatic nucleus (SCN), the regulating site of circadian biological rhythm. In this study, the relationship of ST8SIA2 and NCAM1 with circadian and seasonal rhythms of human behavior ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2017.1410827
更新日期:2018-03-01 00:00:00
abstract::Most research papers published in Chronobiology International report the findings of investigations conducted on laboratory animals and human beings. The Journal, its editors and the publication committee endorse the compliance of investigators to the principles of the Declaration of Helsinki of the World Medical Asso...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-120030045
更新日期:2004-01-01 00:00:00
abstract::Fourteen healthy subjects have been studied in an isolation unit while living on a 30h "day" (20h awake, 10h asleep) for 14 (solar) days but while aware of real time. Waking activities were sedentary and included reading, watching television, and so forth. Throughout, regular recordings of rectal temperature were made...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529609020906
更新日期:1996-10-01 00:00:00