Temporal distribution of [3H]-imipramine binding in rat brain regions is not changed by chronic methamphetamine.

Abstract:

:Specific binding of [3H]-imipramine in the rat suprachiasmatic nuclei, occipital cortex and caudate putamen underwent significant and replicable changes throughout 24 hr under a light-dark cycle or under constant conditions. Daily variations were also found in the medial and dorsal raphe nuclei and the lateral hypothalamus. Methamphetamine, a psychoactive drug with marked effect on circadian rhythms in physiological and hormonal parameters and adrenergic receptors, did not have any significant effect on imipramine binding rhythms in eight discrete brain regions. Thus a drug known to reduce serotoninergic neurotransmission did not change characteristics of the modulatory binding site related to serotonin uptake.

journal_name

Chronobiol Int

authors

Kraeuchi K,Wirz-Justice A,Morimasa T,Suetterlin-Willener R,Feer H

doi

10.3109/07420528609066357

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

127-33

issue

2

eissn

0742-0528

issn

1525-6073

journal_volume

3

pub_type

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