Abstract:
:We evaluated their circadian rhythms using data from electrocardiographic records and examined the change in circadian period related to normal RR intervals for astronauts who completed a long-term (≥6-month) mission in space. The examinees were seven astronauts, five men and two women, from 2009 to 2010. Their mean ± SD age was 52.0 ± 4.2 years (47-59 yr). Each stayed in space for more than 160 days; their average length of stay was 172.6 ± 14.6 days (163-199 days). We conducted a 24-h Holter electrocardiography before launch (Pre), at one month after launch (DF1), at two months after launch (DF2), at two weeks before return (DF3), and at three months after landing (Post), comparing each index of frequency-domain analysis and 24-h biological rhythms of the NN intervals (normal RR intervals). Results show that the mean period of Normal Sinus (NN) intervals was within 24 ± 4 h at each examination. Inter-individual variability differed among the stages, being significantly smaller at DF3 (Pre versus DF1 versus DF3 versus Post = 22.36 ± 2.50 versus 25.46 ± 4.37 versus 22.46 ± 1.75 versus 26.16 ± 7.18 h, p < 0.0001). The HF component increased in 2 of 7 astronauts, whereas it decreased in 3 of 7 astronauts and 1 was remained almost unchanged at DF1. During DF3, about 6 months after their stay in space, the HF component of 5 of 7 astronauts recovered from the decrease after launch, with prominent improvement to over 20% in 3 astronauts. Although autonomic nervous functions and circadian rhythms were disturbed until one month had passed in space, well-scheduled sleep and wake rhythms and meal times served as synchronizers.
journal_name
Chronobiol Intjournal_title
Chronobiology internationalauthors
Yamamoto N,Otsuka K,Kubo Y,Hayashi M,Mizuno K,Ohshima H,Mukai Cdoi
10.3109/07420528.2014.979940subject
Has Abstractpub_date
2015-04-01 00:00:00pages
327-40issue
3eissn
0742-0528issn
1525-6073journal_volume
32pub_type
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journal_title:Chronobiology international
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pub_type: 杂志文章,多中心研究
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journal_title:Chronobiology international
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journal_title:Chronobiology international
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pub_type: 杂志文章,多中心研究
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journal_title:Chronobiology international
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journal_title:Chronobiology international
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