Abstract:
:This study investigates if the serotoninergic system plays a role in chronotoxic effects of the anticancer agent oxaliplatin (l-OHP). Four groups of female rats (120 in total) synchronized with light-dark (12 h:12 h) were treated with: (i) saline, (ii) para-chlorophenylalanine (pCPA, an inhibitor of serotonin biosynthesis: 300 mg/kg/d, i.p. for two consecutive days), (iii) l-OHP (23 mg/kg, i.v.) at three different dosing times, or (iv) both pCPA and l-OHP. The results show pCPA (ii) obliterates the circadian rhythm in plasma ACTH but not in corticosterone or leukocytes, and (iii) l-OHP exerts circadian time-dependent toxic effects (body weight loss, leukopenia, and intestinal lesions) with greatest toxicity coinciding with treatment at the end of the nocturnal activity span (P < 0.05). In rats whose serotonin biosynthesis was blocked (iv), the circadian rhythms in the toxic effects of l-OHP and in ACTH were obliterated, while the rhythms in corticosterone and leukocytes persisted.
journal_name
Chronobiol Intjournal_title
Chronobiology internationalauthors
Boughattas NA,Ben Attia M,Ixart G,Lemaigre G,Mechkouri M,Reinberg Adoi
10.1081/cbi-120015957subject
Has Abstractpub_date
2002-11-01 00:00:00pages
1121-36issue
6eissn
0742-0528issn
1525-6073journal_volume
19pub_type
杂志文章abstract::This study investigated (i) blood pressure (BP), heart rate (HR), and their relation to urinary NOx and eNOS protein expression in male and female spontaneously hypertensive rats (SHR), as well as (ii) gender-dependent cardiovascular effects of nebivolol (NEB) in comparison to metoprolol (MET) in SHR. BP and HR were m...
journal_title:Chronobiology international
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journal_title:Chronobiology international
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journal_title:Chronobiology international
pub_type: 杂志文章,评审
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pub_type: 杂志文章,多中心研究,随机对照试验
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