Exploring the effect of chronotype on hippocampal volume and shape: A combined approach.

Abstract:

:Current evidence suggests that acute depression is associated with reduced total hippocampal volume and regional atrophy. Here, using structural magnetic resonance imaging, we assayed linear effects of chronotype on total hippocampal volume and morphology. Later chronotype was associated with localised atrophy in the subiculum region of the right hippocampus in the absence of changes in total volume. The hippocampus forms a key node in a network of brain regions implicated in emotional regulation and alterations in the structure of this region may underpin, in part, the increased vulnerability for depression in late chronotype individuals.

journal_name

Chronobiol Int

authors

Horne CM,Norbury R

doi

10.1080/07420528.2018.1455056

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

1027-1033

issue

7

eissn

0742-0528

issn

1525-6073

journal_volume

35

pub_type

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