Abstract:
:This study investigated (i) blood pressure (BP), heart rate (HR), and their relation to urinary NOx and eNOS protein expression in male and female spontaneously hypertensive rats (SHR), as well as (ii) gender-dependent cardiovascular effects of nebivolol (NEB) in comparison to metoprolol (MET) in SHR. BP and HR were measured telemetrically after a single intraperitoneal application of NEB or MET at 07.00 and 19.00 h in male rats and at 19.00 h in proestrus female rats. The two beta-blockers varied in time of decreasing BP and HR and also in duration. In males, MET decreased BP and HR for few hours exclusively when applied at the onset of the activity phase (i.e., at 19.00 h), while after its application at 07.00 h, BP and HR were unchanged. In females, MET also caused a short-lasting BP and HR reduction, with the effect being more pronounced than in males. In males, NEB at either dosing time decreased HR and BP to a greater extent than did MET. This effect was evident both during the activity and rest periods and persisted for at least five days. In females, NEB provoked a similar, but more pronounced, effect on BP and HR in comparison to males. These findings demonstrate that significant gender-dependent differences in the circadian profile of BP and HR exist. BP and urinary NOx as well as eNOS expression are inversely correlated, and the cardiovascular effects of NEB and MET vary, depending on the time of application as well as gender.
journal_name
Chronobiol Intjournal_title
Chronobiology internationalauthors
Grundt C,Meier K,Lemmer Bdoi
10.1080/07420520600827129subject
Has Abstractpub_date
2006-01-01 00:00:00pages
813-29issue
4eissn
0742-0528issn
1525-6073pii
P2711W47471Q48Q7journal_volume
23pub_type
杂志文章abstract::Nonrestorative sleep (NRS), characterized by a lack of refreshment upon awakening, has received little attention in the sleep literature even though it can occur and cause impairment apart from other sleep difficulties associated with insomnia. The Restorative Sleep Questionnaire (RSQ) is one of the first validated se...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2016.1212870
更新日期:2016-01-01 00:00:00
abstract::The circalunidian-clock hypothesis is a formulation describing the means by which the tide-associated rhythms of intertidal organisms are generated. The postulate was described in a 1995 article in this journal (12:299-310). A recent paper published here (13:153-62) by Prof. Ernest Naylor challenges the validity of th...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529709001455
更新日期:1997-07-01 00:00:00
abstract::Acute thrombotic events frequently occur in the early morning among hyperlipidemic patients. The activity of plasminogen activator inhibitor-1 (PAI-1), a potent inhibitor of the fibrinolytic system, oscillates daily, and this is considered one mechanism that underlies the morning onset of acute thrombotic events in hy...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2010.515324
更新日期:2010-10-01 00:00:00
abstract::A preliminary study was conducted to evaluate the change in nocturnal concentrations of testosterone, luteinizing hormone, growth hormone, prolactin, thyroxine, and cortisol following a control day (no exercise) and on a day in which exercise was performed. Exercise consisted of 90 min of cycling at 70% of each subjec...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528909056940
更新日期:1989-01-01 00:00:00
abstract::The study aimed at testing chronotype and gender differences in the time of day when humans feel the greatest need for sex and the time of day they actually undertake sexual activity. A Polish sample of 565 participants aged between 18 and 57 was tested. In females, regardless of chronotype, the greatest need for sex ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2014.925470
更新日期:2014-10-01 00:00:00
abstract::Shiftwork, particularly that including night work, causes disruption of biological rhythms and perturbation of the social and family life that can negatively affect performance efficiency, health, and social relations. Adverse effects can manifest themselves in the short term as sleep disturbances, shiftlag syndrome, ...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.3109/07420529709001147
更新日期:1997-03-01 00:00:00
abstract::The present research aimed to investigate in a model of teleost fish (rainbow trout) the existence of daily changes in activity and mRNA abundance of several proteins involved in major pathways of carbohydrate and lipid metabolism in liver, and to test whether or not both the light-dark cycle and food availability mig...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2015.1100633
更新日期:2015-01-01 00:00:00
abstract::In this study, we aimed to show how age affects hibernation in the Syrian hamster. Experimentally, we used 30 male animals differing in age. The old animals were 20 months of age and the adults were 8 months of age at the end of the test. The young animals were 3 weeks old at the start of testing and 5 months old at t...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-100101069
更新日期:2000-09-01 00:00:00
abstract::Using both previously published findings and entirely new data, we present evidence in support of the argument that the circadian dysfunction of advancing age in the healthy human is primarily one of failing to transduce the circadian signal from the circadian timing system (CTS) to rhythms "downstream" from the pacem...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-100101051
更新日期:2000-05-01 00:00:00
abstract::It has been recently discovered that blue wavelengths form the portion of the visible electromagnetic spectrum that most potently regulates circadian rhythm. We investigated the effect of blue light-blocking glasses in subjects with delayed sleep phase disorder (DSPD). This open-label trial was conducted over 4 consec...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2016.1194289
更新日期:2016-01-01 00:00:00
abstract::Diurnal variation in muscle performance has been well documented in the past few years, but almost exclusively in the male population. The possible effects of the menstrual cycle on human circadian rhythms have remained equivocal, particularly in the context of muscle strength. The purpose of the study was to analyze ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-120039206
更新日期:2004-07-01 00:00:00
abstract::In the laboratory rat, a number of physiological parameters display seasonal changes even under constant conditions of temperature, lighting, and food availability. Since there is evidence that prolactin (PRL) is, among the endocrine signals, a major mediator of seasonal adaptations, the authors aimed to examine wheth...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2012.705936
更新日期:2012-10-01 00:00:00
abstract::The effect of altitude on four basic properties of the pacemaker controlling the circadian rhythm of oviposition in two strains of Drosophila ananassae was determined. The high altitude (HA) strain from Badrinath (5123 m above sea level) had a low amplitude peak in the forenoon while the low altitude (LA) strain from ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-200030508
更新日期:2005-01-01 00:00:00
abstract::Individual differences in time of day preference have important correlates. Morningness is associated with greater well-being, while eveningness is associated with more maladaptive behaviors, psychological distress, and disorder. The availability of valid, reliable, questionnaire scales is central to this ongoing rese...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2019.1608225
更新日期:2019-08-01 00:00:00
abstract::This study aimed to investigate the associations between individual difference factors (chronotype, Big Five, emotional competences) and perceived stress in French university students. In total, 362 students agreed to take part (Mage = 20.19 ± 1.75 years). Participants completed the Caen Chronotype Questionnaire, Big ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2020.1752705
更新日期:2020-07-01 00:00:00
abstract::In two experiments, triazolam (2.5 and 1.5 mg/animal) failed to significantly enhance the rate of reentrainment of hamsters (Mesocricetus auratus) to an 8-hr advance of their light-dark cycle. Evidently the phase-shifting effects of triazolam are not robust. The animals did not run much in their wheels in response to ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529009056952
更新日期:1990-01-01 00:00:00
abstract::Shift workers are known to have an increased risk of developing cardiovascular disease (CVD) compared with day workers. An important factor contributing to this increased risk could be the increased incidence of postprandial metabolic risk factors for CVD among shift workers, as a consequence of the maladaptation of e...
journal_title:Chronobiology international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1081/cbi-200037171
更新日期:2004-01-01 00:00:00
abstract::In the current study, we studied behavioral patterns, such as foraging, activity, standing, and laying in a population of cattle wandering on streets of Raipur city. We also determined the effects of four environmental factors (temperature, humidity, light, and noise intensities) on these behaviors. We recorded all fo...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2019.1644345
更新日期:2019-10-01 00:00:00
abstract::Heat resistance appears to cycle in concert with energy metabolism in continuous culture of the yeast Saccharomyces cerevisiae. To study the mechanism of this oscillation, the authors first examined if heat shock proteins (Hsps) are involved. Neither the protein levels of major Hsps nor the expression of the beta-gala...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-120002916
更新日期:2002-03-01 00:00:00
abstract::The circadian clock regulates the daily rhythms of several physiological and behavioral processes. Disruptions in clock genes have been associated with obesity and related comorbidities. This study aimed to analyze the association of DNA methylation signatures at circadian rhythm pathway genes with body mass index (BM...
journal_title:Chronobiology international
pub_type: 杂志文章
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abstract::In 24h studies of bone marrow (BM), circadian stage-dependent variations were demonstrated in the proliferative activity of BM cells from subsets of 35 healthy diurnally active men. On an average, the percentage of total BM cells in deoxyribonucleic acid (DNA) synthesis phase was 188% greater at midday than at midnigh...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
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abstract::The objectives of the study were to investigate the associations between night work and disability pension (DP) due to all causes, cardiovascular (CVD), mental, and other diagnoses, adjusting for familial confounding. The material of the study included comprehensive survey data on 27 165 Swedish twins born in 1935-195...
journal_title:Chronobiology international
pub_type: 杂志文章
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abstract::Specific binding of [3H]-imipramine in the rat suprachiasmatic nuclei, occipital cortex and caudate putamen underwent significant and replicable changes throughout 24 hr under a light-dark cycle or under constant conditions. Daily variations were also found in the medial and dorsal raphe nuclei and the lateral hypotha...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528609066357
更新日期:1986-01-01 00:00:00
abstract::Night work has emerged as a risk factor for many chronic diseases, including obesity, diabetes, and cardiovascular disease. While night work is linked to a number of cardiometabolic indices, few studies have explored how different parameters, such as cumulative night work and intensity of night work, may influence car...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2019.1570247
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abstract::Morningness-eveningness (chronotype) indicates the preferred time of intellectual and physical activity. This cross-sectional study had two main aims. The first aim was to explore associations among chronotype, quality of life, and relationship quality. The second aim of this study was to examine whether the similarit...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2020.1802289
更新日期:2020-12-01 00:00:00
abstract::The circadian clock regulates many cellular processes, notably including the cell cycle, metabolism and aging. Mitochondria play essential roles in metabolism and are the major sites of reactive oxygen species (ROS) production in the cell. The clock regulates mitochondrial functions by driving daily changes in NAD(+) ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2015.1085388
更新日期:2015-01-01 00:00:00
abstract::In previous research, it was determined that the altitude of origin altered the parameters of photic entrainment and free-running rhythmicity of adult locomotor activity of the high-altitude Himalayan (haH) strain (Hemkund-Sahib, 4121 m above sea level) of Drosophila helvetica compared to the low-altitude Himalayan (l...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520701649448
更新日期:2007-01-01 00:00:00
abstract::Fourteen ambulatory subjects, varying in their amount of habitual physical activity, were studied for 24 h during a total of 25 "typical" days. Rectal temperature was recorded every 6 minutes, an activity diary was filled in every half hour, and wrist activity and heart rate were monitored every minute. Actimetry and ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529908998721
更新日期:1999-07-01 00:00:00
abstract::Postoperative delirium, a common perioperative complication, is frequently observed in elderly surgical patients. Few studies have investigated the life rhythm of preoperative patients, and whether or not the preoperative life rhythm is associated with the development of postoperative delirium. The purpose of this stu...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2020.1764012
更新日期:2020-07-01 00:00:00
abstract::General anesthesia combined with surgery is commonly associated with post-operative stress-response in humans. Effects on the hypothalamic-pituitary-adrenal axis (HPA) during and after anesthesia are correlated with the magnitude of surgery and choice of anesthetics. The aim of our study in rats was to characterize th...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520902926033
更新日期:2009-05-01 00:00:00