Abstract:
:This article reviews the experimental and clinical data that form the basis for the chronotherapy of lung carcinoma, specifically, nonsmall cell lung cancer (NSCLC). Circadian rhythms in cell kinetics, immunological and endocrinological endpoints, and tumor markers are reviewed. Chronopharmacology and chronotolerance studies on laboratory animals and clinical observations on cancer patients involving the main drugs active in lung carcinoma have prompted prospective Phase I-III studies to evaluate the application of chronobiologic concepts in the treatment of NSCLC. Circadian rhythmicity in host tolerance (chronotolerance) to medications has been confirmed in two prospective randomized lung cancer trials; a large phase II study has established the value of chronobiologic concepts to improve the therapeutic index of advanced NSCLC.
journal_name
Chronobiol Intjournal_title
Chronobiology internationalauthors
Focan Cdoi
10.1081/cbi-120002601subject
Has Abstractpub_date
2002-01-01 00:00:00pages
253-73issue
1eissn
0742-0528issn
1525-6073journal_volume
19pub_type
杂志文章,评审abstract::Although there are significant intra-individual differences in self-reported diurnal preference, as measured by validated questionnaires, the relative contribution of exogenous and endogenous factors to self-reported diurnal preference largely remains to be investigated. The present study examined which items from the...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520902820970
更新日期:2009-04-01 00:00:00
abstract::Freshwater crayfish have three known photoreceptive systems: the compound eyes, extraretinal brain photoreceptors, and caudal photoreceptors. The primary goal of the work described here was to explore the contribution of the brain photoreceptors to circadian locomotory activity and define some of the underlying neural...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420520903217960
更新日期:2009-08-01 00:00:00
abstract::The phase and period responses to short light pulses were studied in the jerboa, a seasonal, hibernating, nocturnal rodent from the Atlas region in Morocco. The jerboa, which is a saltatory species, showed precise activity onsets and offsets under a light-dark (LD) cycle using infrared captors to record locomotor acti...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2010.504315
更新日期:2010-08-01 00:00:00
abstract::Fabry disease is a progressive disease characterized by an enzymatic deficiency of acid alpha-galactosidase and glycosphingolipids storage within the lysosomes. The disease has two phenotypes: classic and nonclassic. Excessive daytime sleepiness is a common sign reported by patients and can be caused by a circadian rh...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2018.1560308
更新日期:2019-04-01 00:00:00
abstract::Twenty-one children aged 5-6 years (mean age: 71.2 months; S.D. = 2.7) were videotaped in 4 different kindergartens throughout the school day for a period of one week. Eighteen of these children were then followed up after the summer holidays and videotaped for one week while attending the first year of primary school...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528709078544
更新日期:1987-01-01 00:00:00
abstract::Despite research indicating that sleep disorders influence reproductive health, the effects of sleep on reproductive hormone concentrations are poorly characterized. We prospectively followed 259 regularly menstruating women across one to two menstrual cycles (the BioCycle Study, 2005-2007), measuring fasting serum ho...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2019.1694938
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Patients with mood disorders show a high dependence of behavior on the molecular characteristics of the biological clock. CLOCK rs1801260 gene polymorphism influences circadian behavior in bipolar disorder (BD), with *C carriers showing a delayed sleep onset and worse insomnia. Sleep phase delay and insomnia...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2015.1060603
更新日期:2015-01-01 00:00:00
abstract::The circadian melatonin rhythm is highly reproducible and generally not easily altered. The few perturbations that are capable of significantly changing either the amplitude or the pattern of the 24-h melatonin rhythm are summarized herein. Aging alters cyclic melatonin production by decreasing the amplitude of the no...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.3109/07420529209064541
更新日期:1992-08-01 00:00:00
abstract::One of the supposed mechanisms that may lead to breast cancer (BC) is an alteration of circadian gene expression and DNA methylation. We undertook an integrated approach to identify methylation pattern of core circadian promoter regions in BC patients with regard to clinical features. We performed a quantitative methy...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2019.1617732
更新日期:2019-08-01 00:00:00
abstract::Chronic sympathetic denervation of the pineal gland by bilateral removal of the superior cervical ganglia (SCG) was performed on female rats 30 days before impregnation. The offspring, maintained in the dark from birth, had disruption of the malate dehydrogenase circadian rhythm in the testes at 25 days of age. A dail...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529509064495
更新日期:1995-02-01 00:00:00
abstract::Sleep and fatigue-associated symptoms are prominent during chemotherapy. The purpose of this pilot study was to examine bright light effects on sleep disruption, fatigue, daytime sleepiness, depression, and quality of life (QOL) in women with stage I-III breast cancer undergoing chemotherapy. In this 2-group randomize...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2021.1871914
更新日期:2021-01-21 00:00:00
abstract::Ninety-five nonresident girls of a private school volunteered for the study with the teachers' help as well as parental consent. Ages were approximately 8, 9, and 10 years. They were synchronized with diurnal activity from 0730 to 2100 h and nocturnal rest. Fatigue, drowsiness, and attention were self-rated using visu...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529109059164
更新日期:1991-01-01 00:00:00
abstract::The purpose of this study was to evaluate the effects of partial sleep deprivation (PSD) on circulating concentrations of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in relation to the secretory profiles of growth hormone (GH), cortisol, and testosterone during a repeated brief sprint interval exercis...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2012.742102
更新日期:2013-05-01 00:00:00
abstract::Circadian rhythms in mammals are driven by a central clock in the suprachiasmatic nucleus (SCN). In vitro, temperature cycles within the physiological range can act as potent entraining cues for biological clocks. We altered the body temperature (Tc) rhythm in rats by manipulating energy intake (EI) to determine wheth...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2015.1112395
更新日期:2016-01-01 00:00:00
abstract::The properties of the circadian photoperiodic oscillator have been investigated in detail only in the Japanese quail. While the study of the quail is clearly very important, one cannot simply assume that other species, especially passerines that seem to have a different circadian organization than quail, function the ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-120014570
更新日期:2002-09-01 00:00:00
abstract::The ventromedial hypothalamic nucleus (VMH) regulates various autonomic, endocrine, and behavioral activities. These activities show annual changes, and the pineal gland is involved in their adjustment to environmental cues. Therefore, this study investigated whether the VMH belongs to the effector structures of the p...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-100101028
更新日期:2000-01-01 00:00:00
abstract::Heat resistance appears to cycle in concert with energy metabolism in continuous culture of the yeast Saccharomyces cerevisiae. To study the mechanism of this oscillation, the authors first examined if heat shock proteins (Hsps) are involved. Neither the protein levels of major Hsps nor the expression of the beta-gala...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-120002916
更新日期:2002-03-01 00:00:00
abstract::In the contemporary era, when life habits are largely determined by social needs and individual preferences, sleep is nevertheless affected by seasonal environmental changes. Japan has large seasonal and geographical alterations of photoperiod and climate. Japan does not adopt the daylight saving time (DST) system, ma...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2018.1443118
更新日期:2018-07-01 00:00:00
abstract::Diurnal variation in muscle performance has been well documented in the past few years, but almost exclusively in the male population. The possible effects of the menstrual cycle on human circadian rhythms have remained equivocal, particularly in the context of muscle strength. The purpose of the study was to analyze ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-120039206
更新日期:2004-07-01 00:00:00
abstract::In birds, circadian control of tissue level communication is not well understood. The present study investigated this, by monitoring daily oscillation of genes coding for peptides (neuropeptide Y, NPY; vasoactive intestinal peptide, VIP; somatostatis, SST) and intermediary enzymes of amine and amino acid neurotransmit...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2016.1139587
更新日期:2016-01-01 00:00:00
abstract::The molecular circadian clock mechanism is highly conserved between mammalian and avian species. Avian circadian timing is regulated at multiple oscillatory sites, including the retina, pineal, and hypothalamic suprachiasmatic nucleus (SCN). Based on the authors' previous studies on the rat ovary, it was hypothesized ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2010.530363
更新日期:2011-02-01 00:00:00
abstract::Seasonal Affective Disorder (SAD) is a condition of regularly occurring depressions in winter with a remission the following spring or summer. In addition to depressed mood, the patients tend to experience increased appetite and an increased duration of sleep during the winter. SAD is a relatively common condition, af...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.1081/cbi-120019310
更新日期:2003-03-01 00:00:00
abstract::Nineteen adult cancer patients each received 6-10 monthly treatments of doxorubicin and cisplatin. For 24-30 hr before each treatment, recumbent pulse was measured. Treatment was stopped for disease progression or when a total doxorubicin dose of 550 mg/m2 was reached. No patient developed congestive heart failure (CH...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528409059119
更新日期:1984-01-01 00:00:00
abstract::The season of birth has been suggested to influence the development of some diseases, but its role in lung fibrosis seems to not have been studied previously. The aim of this study was to investigate the relation between the season of birth and fibrotic abnormalities as detected radiologically in high-resolution compu...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520701420725
更新日期:2007-01-01 00:00:00
abstract::Time-dependent variations in the vasodilator effects of beta-adrenergic agonists terbutaline (Ter) and dobutamine (Dob) were studied in isolated rings of rat thoracic aorta in both endothelium-intact and endothelium-denuded preparations. Rats were housed in light from 08:00 to 20:00 and in darkness from 20:00 to 08:00...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529808998680
更新日期:1998-03-01 00:00:00
abstract::Equity is a humanitarian issue that gained strength during the transition from the 20th to the 21st century due to the mounting global discussion and social crisis involving human rights, health, and work. This article aims at (1) introducing the concept of equity as it applies to work environments, particularly to si...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-200044991
更新日期:2004-01-01 00:00:00
abstract::Semilunar and lunar rhythms are often controlled endogenously, but the mechanisms of their respective free-run periods, when external factors are absent, are mostly unclear. In this investigation, the authors studied the mechanism controlling the period of the circasemilunar emergence rhythm of a marine midge, Pontomy...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2012.728548
更新日期:2012-12-01 00:00:00
abstract::The aim of this study was to examine the effect of the interaction of circamensal and diurnal rhythms in temperature upon the production of maximal voluntary muscle force. Ten eumenorrheic females (mean age: 24 +/- 3 yr mean body mass: 58.4 +/- 6.9 kg) participated in the experiment at both 06:00 and 18:00h at the mid...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-120006083
更新日期:2002-07-01 00:00:00
abstract::Sleep-related problems, such as symptoms of insomnia, daytime sleepiness, shorter sleep duration, or a delayed sleep-wake schedule, are known to be risk factors for depression. In general, depression is more prevalent in women than in men, but sleep-related problems do not necessarily show similar gender predominance....
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2015.1055756
更新日期:2015-01-01 00:00:00
abstract::There is strong association between chronic kidney disease (CKD) and increased prevalence of hypertension, risk of end-organ damage, and cardiovascular disease (CVD). Non-dipping, as determined by ambulatory blood pressure (BP) monitoring (ABPM), is frequent in CKD and has also been consistently associated with increa...
journal_title:Chronobiology international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.3109/07420528.2012.703083
更新日期:2013-03-01 00:00:00