Abstract:
:Nineteen adult cancer patients each received 6-10 monthly treatments of doxorubicin and cisplatin. For 24-30 hr before each treatment, recumbent pulse was measured. Treatment was stopped for disease progression or when a total doxorubicin dose of 550 mg/m2 was reached. No patient developed congestive heart failure (CHF) during therapy. Two to four months after stopping treatment, three patients developed CHF. In these cases, 2-6 months before complication of therapy, prior to notable decrement in any other index of cardiac function, the 24-hr rhythm-qualified mean (mesor) of pulse showed a positive slope by linear regression analysis (P less than 0.05). This mesor rise was apparent at cumulative doxorubicin doses of 300, 420 and 240 mg/m2. patients subsequently received additional doxorubicin to total doses of 540, 525 and 530 mg/m2. Patients who did or did not experience a rise in pulse received similar total doses of doxorubicin. Serial pulse mesors predicted CHF reliably and were substantially less expensive than radionuclide ejection fraction determination ($200 per test). A progressive rise in the circadian pulse-mesor was clearly a harbinger of histologically documented doxorubicin-induced lethal CHF in Wistar-Kyoto rats of both sexes.
journal_name
Chronobiol Intjournal_title
Chronobiology internationalauthors
Hrushesky WJ,Vukelich Mdoi
10.3109/07420528409059119subject
Has Abstractpub_date
1984-01-01 00:00:00pages
59-66issue
1eissn
0742-0528issn
1525-6073journal_volume
1pub_type
杂志文章abstract::High fat diet (HFD) consumption alters the synchronized circadian timing system resulting in harmful loss, gain or shift of transcriptional oscillations. The aryl hydrocarbon receptor (AhR) shares structural homology to clock genes, containing both PAS domains and basic helix-loop helix structural motifs, allowing for...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2016.1256298
更新日期:2017-01-01 00:00:00
abstract::Police officers are required to work irregular hours, which induces stress, fatigue, and sleep disruption, and they have higher rates of chronic disease and mortality. Cortisol is a well-known "stress hormone" produced via activation of the hypothalamic-pituitary-adrenal axis. An abnormal secretion pattern has been as...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2011.573112
更新日期:2011-05-01 00:00:00
abstract::A circadian rhythm of heart rate and respiratory rate was seen at 1, 8, and 12 months of age in an infant born without ocular tissue, which supports the possibility that the time cues were nonphotic. No melatonin circadian rhythm was detected at any age up to 9 years of age, and this is most likely associated with the...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-120037809
更新日期:2004-03-01 00:00:00
abstract::The aim of this study was to examine the sleep strategies used in breaks between consecutive shifts. For two weeks, 253 shiftworkers collected data regarding the timing of all shifts and sleeps. The final dataset included 395 between-shift breaks that had a standard duration (i.e. ~16 h). If a break included an entire...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2016.1167716
更新日期:2016-01-01 00:00:00
abstract::Population multiple components is a statistical tool useful for the analysis of time-dependent hybrid data. With a small number of parameters, it is possible to model and to predict the periodic behavior of a population. In this article, we propose two methods to compare among populations rhythmometric parameters obta...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-120038630
更新日期:2004-05-01 00:00:00
abstract::Four healthy non obese young volunteers were observed for a 24-hr period, every other month, over the course of one year. Tolbutamide was injected i.v. each day of the experiment every four hours. Tolbutamide-induced insulin secretion (T.I.I.S.) was evaluated by planimetrically measuring insulin areas above basal leve...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528409063899
更新日期:1984-01-01 00:00:00
abstract::Eveningness has been suggested as a facilitating factor in adaptation to shift work, with several studies reporting evening chronotypes (E-types) as better sleepers when on night shifts. Conversely, eveningness has been associated with more sleep complaints during day shifts. However, sleep during day shifts has recei...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2015.1033425
更新日期:2015-06-01 00:00:00
abstract::Many immune parameters exhibit daily and circadian oscillations, including the number of circulating cells and levels of cytokines in the blood. Mice also have a differential susceptibility to lipopolysaccharide (LPS or endotoxin)-induced endotoxic shock, depending on the administration time in the 24 h light-dark (LD...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420520903408358
更新日期:2009-10-01 00:00:00
abstract::Previously, we have demonstrated the postembryonic development of chicken (Gallus gallus domesticus L.) pineal gland functions expressed as changes in melatonin (MEL) biosynthesis. Pineal concentrations of MEL and its precursor serotonin (5-HT) were shown to increase between the 2nd and 16th day of life. We also found...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2014.955185
更新日期:2015-02-01 00:00:00
abstract::Bone sarcomatous cells derived from human malignant tumors were cultured. The mitotic index was recorded for 39 hr. When the cultured cells originated from patients with cancer disease before any chemotherapy, ultradian mitotic rhythms of a 6-9-hr period were detected, but in many cases only after a sensitive statisti...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528909064628
更新日期:1989-01-01 00:00:00
abstract::The suprachiasmatic nucleus (SCN) of the hypothalamus controls circadian rhythmicity in mammals (for reviews, see Refs. 33 and 59). Responses modulated by the SCN are numerous and include rhythms in sleep/wake cycles, locomotor, gnawing and general activity, temperature, ingestive behavior, and rhythms of hormonal and...
journal_title:Chronobiology international
pub_type: 杂志文章,评审
doi:10.3109/07420529808998706
更新日期:1998-09-01 00:00:00
abstract::In the current study, we studied behavioral patterns, such as foraging, activity, standing, and laying in a population of cattle wandering on streets of Raipur city. We also determined the effects of four environmental factors (temperature, humidity, light, and noise intensities) on these behaviors. We recorded all fo...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2019.1644345
更新日期:2019-10-01 00:00:00
abstract::Circadian rhythms are still expressed in animals that display daily torpor, implying a temperature compensation of the pacemaker. Nevertheless, it remains unclear how the clock works in hypothermic states and whether torpor itself, as a temperature pulse, affects the circadian system. To reveal changes in the clockwor...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520500522424
更新日期:2006-01-01 00:00:00
abstract::Semilunar and lunar rhythms are often controlled endogenously, but the mechanisms of their respective free-run periods, when external factors are absent, are mostly unclear. In this investigation, the authors studied the mechanism controlling the period of the circasemilunar emergence rhythm of a marine midge, Pontomy...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2012.728548
更新日期:2012-12-01 00:00:00
abstract::The ventromedial hypothalamic nucleus (VMH) regulates various autonomic, endocrine, and behavioral activities. These activities show annual changes, and the pineal gland is involved in their adjustment to environmental cues. Therefore, this study investigated whether the VMH belongs to the effector structures of the p...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1081/cbi-100101028
更新日期:2000-01-01 00:00:00
abstract::The human sleep-wake cycle is characterized by significant individual differences. Those differences in the sleep-wake cycle are partially heritable but are also influenced by environmental factors like the light/dark cycle or social habits. In this study we analyse for the first time the sleep-wake rhythm of adolesce...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2012.741173
更新日期:2012-12-01 00:00:00
abstract::Influences of starvation, re-feeding and time of food supply on daily rhythm features of melatonin (5-methoxy-N-acetyltryptamine) and its key regulator AANAT (arylalkylamine N-acetyltransferase) protein in the gut tissues were separately evaluated in carp Catla catla. The first experiment was aimed at demonstration of...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2015.1087020
更新日期:2015-01-01 00:00:00
abstract::We have recently demonstrated that the outcome of repeated social defeat (SD) on behavior, physiology and immunology is more negative when applied during the dark/active phase as compared with the light/inactive phase of male C57BL/6 mice. Here, we investigated the effects of the same stress paradigm, which combines a...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2014.940085
更新日期:2014-11-01 00:00:00
abstract::A physiological dose of orally administered melatonin shifts circadian rhythms in humans according to a phase-response curve (PRC) that is nearly opposite in phase with the PRCs for light exposure: melatonin delays circadian rhythms when administered in the morning and advances them when administered in the afternoon ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529209064550
更新日期:1992-10-01 00:00:00
abstract::Chronic sympathetic denervation of the pineal gland by bilateral removal of the superior cervical ganglia (SCG) was performed on female rats 30 days before impregnation. The offspring, maintained in the dark from birth, had disruption of the malate dehydrogenase circadian rhythm in the testes at 25 days of age. A dail...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529509064495
更新日期:1995-02-01 00:00:00
abstract::In amphibians, voltage-gated sodium (Nav) channels in cone ON bipolar cells (ON-CBC) amplify cone signals in the dark and in mesopic background light. However, during light adaptation, dopamine, acting through D1 receptors (D1R), suppresses Nav channels and therefore act as a gain control mechanism. Curiously in roden...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2014.951054
更新日期:2015-02-01 00:00:00
abstract::Eight diurnally active (06:00-23:00 h) subjects were adapted for 2 days to the room conditions where the experiments were performed. Blood sampling for adenosine metabolites and metabolizing enzymes was done hourly during the activity span and every 30 min during sleep. The results showed that adenosine and its catabo...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420529609012650
更新日期:1996-08-01 00:00:00
abstract::Twenty-one children aged 5-6 years (mean age: 71.2 months; S.D. = 2.7) were videotaped in 4 different kindergartens throughout the school day for a period of one week. Eighteen of these children were then followed up after the summer holidays and videotaped for one week while attending the first year of primary school...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528709078544
更新日期:1987-01-01 00:00:00
abstract::It has been previously documented that aspirin induced gastric injury of healthy male volunteers was greater in the morning than in the evening. We have also reported that fasting gastric acid secretion rates and gastric retention times for solids were lower in the morning hours of the circadian cycle. We hypothesized...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528809067784
更新日期:1988-01-01 00:00:00
abstract::This study aims to investigate independent associations of habitual sleep durations and sleep timings on weekdays and weekends with depressive symptoms in adolescents who have classes in the morning. We studied grade 7-9 students (942 males and 940 females, aged 12-15 years), who had classes in the morning, at public ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2020.1746796
更新日期:2020-06-01 00:00:00
abstract::The evening chronotype is strongly associated with greater alcohol use, though mechanisms underlying this association are not well understood. The current study evaluated emotion regulation as a potential mechanism linking evening chronotype and alcohol use. Participants were 81 undergraduate students. Chronotype was ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2020.1800028
更新日期:2020-12-01 00:00:00
abstract::Therapy with oral anticoagulants (OACs) is a risk factor for cerebral hemorrhage (CH). Although different studies have been undertaken to investigate the timing of the onset of major cardiovascular events, no data exist on temporal patterns of the onset of CH in subjects treated with OACs. The aim of this study is to ...
journal_title:Chronobiology international
pub_type: 杂志文章,多中心研究
doi:10.3109/07420528.2015.1133636
更新日期:2016-01-01 00:00:00
abstract::The objective of the present study was to evaluate the sexual behavior of male rats kept under constant laboratory conditions for one entire year. A total of 213 sexually-inexperienced, male Wistar rats were maintained in controlled environmental conditions from birth. Depending the month in which they reached the age...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420528.2020.1715997
更新日期:2020-02-01 00:00:00
abstract::The increased prevalence of circadian disruptions due to abnormal coupling between internal and external time makes the detection of circadian phase in humans by ambulatory recordings a compelling need. Here, we propose an accurate practical procedure to estimate circadian phase with the least possible burden for the ...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.3109/07420528.2013.820740
更新日期:2014-02-01 00:00:00
abstract::This study investigated (i) blood pressure (BP), heart rate (HR), and their relation to urinary NOx and eNOS protein expression in male and female spontaneously hypertensive rats (SHR), as well as (ii) gender-dependent cardiovascular effects of nebivolol (NEB) in comparison to metoprolol (MET) in SHR. BP and HR were m...
journal_title:Chronobiology international
pub_type: 杂志文章
doi:10.1080/07420520600827129
更新日期:2006-01-01 00:00:00