Nuclear omnipotent suppressors of premature termination codons in mitochondrial genes affect the 37S mitoribosomal subunit.

Abstract:

:nam3 and R705, yeast nuclear omnipotent suppressors of mitochondrial mit- mutations, reverse the superimposed spectrum of trans-recessive splicing defects by affecting the protein composition of the small mitoribosomal subunit. Analysis of the suppressor's interaction suggests that suppression results from mutations in the mitoribosomal polypeptides. These data indicate an obligatory connection between mitoribosome function and splicing of introns bI2, bI4 and aI1 in yeast mitochondria.

journal_name

Curr Genet

journal_title

Current genetics

authors

Boguta M,Mieszczak M,Zagórski W

doi

10.1007/BF00365647

subject

Has Abstract

pub_date

1988-02-01 00:00:00

pages

129-35

issue

2

eissn

0172-8083

issn

1432-0983

journal_volume

13

pub_type

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