Abstract：
:The effect of oxoplatinum on blastic transformation of human peripheral blood mononuclear cells (PBMC) was monitored following phytohemagglutinin (PHA) stimulation. The results were compared with those published in part III of the present work as well as with the effect of cisplatinum and carboplatinum on the blastic transformation of human cells. In addition, the influence of three Pt-cytostatics on blastic transformation (BT) of PHA pretreated murine splenic cells was studied, and a comparison of sensitivity to cytostatics was made between the murine splenic and human peripheral cells. Cisplatinum demonstrated the highest toxicity, and carboplatinum showed minimum toxicity. The highest inhibitory effect was noted when cytostatics were applied either simultaneously with, or 48 h after PHA, i.e., at the stage of maximum proliferating activity. The murine spleen cells showed higher susceptibility to the effect of Pt-cytostatics in blastic transformation test than human peripheral cells. The murine spleen nuclear cells revealed deeper BT inhibition at the same concentration of substance than the human PBMC.
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Kanková-Vancurová M,Procházková Jsubject
Has Abstractpub_date
1991-01-01 00:00:00pages
213-21issue
2eissn
0028-2685issn
1338-4317journal_volume
38pub_type
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