Potential carcinogenic and inhibitory activity of compounds isolated from Lilium candidum L.

Abstract:

:This paper deals with determination of potential carcinogenic and inhibitory activity of 10 compounds isolated from the ethanolic extract of Lilium candidum L. perfonned by DC polarography. The series of investigated compounds consisted of two spirostanol saponins, two pyroline derivatives, jatropham and its glucoside, flavonol kaempferol, 2-fenylethyl-alpha-L-arabinopyranosyl-(1-->6)-beta-D-glucopyranoside, 2-phenylethylpalmitate and methylsuccinic acid. Carcinogenic, resp. mutagenic activity data for these compounds, with the exception of kaempferol, are not available in scientific literature. All tested compounds were reduced in N,N-dimethylformamide in one or two well defined steps. They also fonned a reversible complex with alpha-lipoic acid, a compound serving as an indicator of carcinogenic activity. The marginal diffuse current values of these complexes served as a criterion of a very low potential carcinogenicity. The inhibitory activity of isolates were studied in the presence of 12-O-tetradecanoylphorbol-13-acetate, a specific tumor promoter for an epidermal carcinogenesis, and in the presence of a polyaromatic substance 7,12-dimetylbenz(a)anthracene known as a carcinogen. The spirostanol saponins possessed the highest inhibitory activity (> 70%) and jatropham (66%). The inhibitory activity of jatropham glucoside was significantly lower (49%). Practically zero inhibitory activity was measured for the 2-phenylethylpalmitate and methylsuccinic acid.

journal_name

Neoplasma

journal_title

Neoplasma

authors

Vachálková A,Eisenreichová E,Haladová M,Mucaji P,Józová B,Novotný L

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

313-8

issue

5

eissn

0028-2685

issn

1338-4317

journal_volume

47

pub_type

杂志文章
  • Factors associated with prognosis in human breast cancer. I. Predictors for rate of evolution and relapse.

    abstract::The associations of several clinical factors with general survival, percentage of relapse and survival in the group of patients who relapsed were analyzed in a series of 399 Stage II breast cancer patients operated and irradiated at the Institute of Oncology and Radiobiology in Havana. In another series of 187 patient...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Lage A,Rodriguez M,Pascual MR,Diaz JW,Fernandez L

    更新日期:1983-01-01 00:00:00

  • The pattern of human lymph node involvement by the non-Hodgkin lymphomas of B-cell lineage.

    abstract::A total of 93 lymph nodes from 24 patients with a primary malignant non-Hodgkin lymphoma of B-cell lineage was assessed histologically with special reference to the presence or absence of neoplastic B-cells in the lymph node cortex and medulla (B-cell areas) as well as in the paracortical (T-cell area) area, and in th...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Syrjänen KJ

    更新日期:1979-01-01 00:00:00

  • Genetic background of high incidence of spontaneous tumors in BDX rats.

    abstract::Genetic background of high incidence of spontaneous tumors in BDX rats was investigated with respect to susceptibility to physical or chemical agents and immune response. Percentages of colony forming ability of normal embryo fibroblasts from BDX rats after exposure to various doses of ultraviolet (UV) light, X-rays a...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Oikawa T,Koga Y,Tanahashi K,Saito T,Kobayashi H,Kuzumaki N

    更新日期:1986-01-01 00:00:00

  • Etiology of candidemia in patients with solid tumors - 7 years of experience of one oncology center.

    abstract::Although the candidemia still remains a serious health problem, the study of candidemia in cancer patients is limited. We conducted a retrospective analysis of candidemia among 31 adult patients hospitalized in one oncological center. The mean annual incidence of candidemia was 0.14±0.05/1000 patient-days (range 0.04-...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2020_200204N105

    authors: Szymankiewicz M,Nowikiewicz T

    更新日期:2020-11-01 00:00:00

  • Some data concerning immune processes in concomitant tumor immunity experimental models. Comparative in vivo and in vitro investigations II. In vitro experiments.

    abstract::The humoral and cellular immune status of C57BL/6 male mice and "R" male rats bearing MC-induced sarcomas were investigated in vitro, using 51Cr-releasing and mixed hemadsorption assays. Analysis was performed on mice subjected to concomitant tumor immunity (CTI) model experiments or bearing primary tumors of differen...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Donovan G,Popp I,Badea E,Bologa L

    更新日期:1977-01-01 00:00:00

  • Tumor necrosis factor-alpha: molecular-biological aspects minireview.

    abstract::Tumor necrosis factor-alpha (TNF-alpha) a proinflammatory cytokine with multiple actions was first identified for its anticancer activity. However, TNF-alpha has a beneficial function in activation of host defense, its uncontrolled production can lead to pathological consequences. At the cellular level, it is able to ...

    journal_title:Neoplasma

    pub_type: 杂志文章,评审

    doi:

    authors: Szatmáry Z

    更新日期:1999-01-01 00:00:00

  • The intermediate filaments and prognostically oriented morphological classification in ductal breast carcinoma.

    abstract::The expression of cytokeratins 7, 8, 14, 18, 19 and vimentin was examined in 100 cases of ductal invasive breast carcinomas. While the predominantly diffuse immunohistological positivity of simple epithelia cytokeratins 7 (in 93), 8 (in 100), 18 (in 100) and 19 (in 97) cases represents a constant feature of these tumo...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Rejthar A,Nenutil R

    更新日期:1997-01-01 00:00:00

  • Synergic effects of the cyclin-dependent kinase (CDK) inhibitor olomoucine and androgen-antagonist bicalutamide on prostatic cancer cell lines.

    abstract::Currently, mechanisms leading to both apoptosis induction and the development of hormone-independence of prostate carcinoma cells are intensively studied. Attention is also given to the possibility of restoring cell sensitivity to hormone-antagonists. The present study focuses on the effect of the combined synthetic c...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Knillová J,Bouchal J,Hlobilková A,Strnad M,Kolár Z

    更新日期:2004-01-01 00:00:00

  • The antitumor activity of oxoplatinum.

    abstract::A coordination complex cis-dichlorodiamminedihydroxoplatinum (IV) (oxoplatinum) was first synthesized in the USSR by Chugaev and Khlopin in 1927 [3]. Its marked antitumor properties were revealed by one of the authors of this article at the All-Union Cancer Research Center of the Academy of Medical Sciences of the USS...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Presnov MA,Konovalova AL,Kozlov AM,Brovtsyn VK,Romanova LF

    更新日期:1985-01-01 00:00:00

  • Treatment of newly diagnosed patients with acute promyelocytic leukemia with modified spanish treatment protocol.

    abstract::The results of treatment of acute promyelocytic leukemia, when combination ATRA + chemotherapy is used in induction and maintainance therapy and risk adapted strategy applied in consolidation, improved at present time. Enhanced supportive therapy also contribute to improved outcome of APL patients. 3 - year relapse fr...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2010_03_270

    authors: Oravcova I,Czako B,Demeckova E,Demitrovicova L,Greksak R,Kotoucek P,Mego M,Mikuskova E,Richterova K,Al Sabti F,Mistrik M

    更新日期:2010-01-01 00:00:00

  • Tumor size and prognosis of breast cancer with negative axillary nodes.

    abstract::A report on 1877 consecutive node negative (N-) breast cancer cases is presented in which the prognostic value of the main clinico-pathologic features is evaluated. Tumor size (and UICC-TNM T category) and lobular infiltrating histologic type were significantly associated with a more favorable prognosis whereas no ass...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Ciatto S,Cecchini S,Grazzini G,Iossa A,Bartoli D,Rasponi A

    更新日期:1990-01-01 00:00:00

  • MicroRNA-101 regulates autophagy, proliferation and apoptosis via targeting EZH2 in laryngeal squamous cell carcinoma.

    abstract::Laryngeal carcinoma is the second commonest head and neck carcinoma globally. MicroRNA-101 (miR-101) has been reported as a tumor suppressor in multiple malignancies including laryngeal squamous cell carcinoma (LSCC). However, the roles and molecular mechanisms of miR-101 in the development of LSCC have not been fully...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2018_180811N611

    authors: Chen L,Jia J,Zang Y,Li J,Wan B

    更新日期:2019-07-23 00:00:00

  • Combined molecular biological and molecular cytogenetic analysis of genomic changes in 146 patients with B-cell chronic lymphocytic leukemia.

    abstract::Interphase fluorescence in situ hybridization was used to detect common deletions in B-CLL patients as well as trisomy 12 and aberrations of IgH gene complex at 14q32.33 where we evaluated not only translocation-like signal pattern but also deletions. 120 (82%) patients showed genetic changes - del(13)(q14) 95 (62%), ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Berkova A,Pavlistova L,Babicka L,Houskova L,Tajtlova J,Balazi P,Cmunt E,Schwarz J,Karban J,Trneny M,Brezinova J,Zemanova Z,Michalova K

    更新日期:2008-01-01 00:00:00

  • Vitamin D receptor FokI, BsmI, ApaI, and TaqI polymorphisms and the susceptibility to breast cancer: a meta-analysis.

    abstract::The goal of this study is to examine whether vitamin D receptor (VDR) polymorphisms are associated with the susceptibility to breast cancer. Meta-analysis was employed to investigate the association between the VDR FokI, BsmI, ApaI, and TaqI polymorphisms and the incidence of breast cancer.A total of 32 comparative st...

    journal_title:Neoplasma

    pub_type: 杂志文章,meta分析

    doi:10.4149/neo_2014_077

    authors: Lee YH,Song GG

    更新日期:2014-01-01 00:00:00

  • Cytogenetic studies in polycythemia vera.

    abstract::A group of 54 patients with the original diagnosis of polycythemia vera were subjected to cytogenetic examination. Six (17.6%) of the 34 cases examined in the period of the advanced phase of the polycythemia vera had a chromosomal change. Thirteen (65%) of the 20 patients undergoing the cytogenetic examination in the ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Jarosová M,Indrák K,Dusek J,Kapustová M

    更新日期:1988-01-01 00:00:00

  • Production of plasminogen activator and inhibition of embryonic cell aggregation by cultured human normal and neoplastic cells.

    abstract::The plasminogen activator (PA) production and the capacity to inhibit embryonic neural retina (NR) cell aggregation by human normal and neoplastic cell lines have been studied. The PA production was detected by both iodinated fibrin and casein lysis assays, and by changes in cell morphology at the presence of activate...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Phan Thu A,Popovic M

    更新日期:1979-01-01 00:00:00

  • Detection and characterization of ciRS-7: a potential promoter of the development of cancer.

    abstract::Circular RNAs (circRNAs) are a class of newly-identified non-coding RNA molecules. CircRNAs are conserved across different species and display specific organization, sequence, and expression in disease. Moreover, circRNAs' closed ring structure, insensitivity to RNase, and stability are advantages over linear RNAs in ...

    journal_title:Neoplasma

    pub_type: 杂志文章,评审

    doi:10.4149/neo_2017_301

    authors: Zheng XB,Zhang M,Xu MQ

    更新日期:2017-01-01 00:00:00

  • Ovarian and endometrial endometrioid carcinoma: diagnostic implications of flow cytometry.

    abstract::Surgical specimens from two patients with simultaneously occurring ovarian and endometrial endometrioid carcinoma were studied by flow cytometry (FCM) and routine histological examination. Tissue derived from the uterine and the ovarian lesion showed similar FCM curves in each case. The information obtained from FCM w...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Vassilev NB,Christov KT,Raychev RD

    更新日期:1986-01-01 00:00:00

  • Endocrine factors in the etiology of endometrial carcinoma.

    abstract::In the blood of 39 women with endometrial carcinoma the FSH, LH, estrone, androstendion, estradiol and dehydroepiandrosterone were determined by the RIA method. Compared to the control group the estrone (303.3 +/- 44.3 pmol/l), estradiol (165.2 +/- 29.4 pmol/l) and the androstendion (5.24 +/- 0.44 nmol/l) were signifi...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Gimes G,Szarvas Z,Siklósi G

    更新日期:1986-01-01 00:00:00

  • Serum and urinary levels of CD222 in cancer: origin and diagnostic value.

    abstract::The mannose 6-phosphate/insulin-like growth factor 2 receptor (CD222, M6P/IGF2R) is a multifunctional transmembrane type I receptor, mostly localized intracellularly, less on the surface of all types of mammalian cells. It is known both to transport lysosomal enzymes through their mannose 6-phosphate moieties and to i...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2018_171203N792

    authors: Vicikova K,Petrovcikova E,Manka P,Drach J,Stockinger H,Leksa V

    更新日期:2018-09-19 00:00:00

  • Relation between the chemical structure and acute toxicity of 1-phenyl-3-methyltriazenes as activated metabolites during the carcinogenic action of 1-phenyl-3,3-dimethyltriazenes.

    abstract::The mol LD50 values were correlated with Hammett sigma constants in terms of the Hansen empiric equation 6 for para substituted derivatives of 1-phenyl-3-methyltriazene. Good agreement was achieved and the line slope of the correlation, 0.3, is the same as that found during an identical experiment with derivatives of ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Matrka M,Rambousek V,Zvĕrina V

    更新日期:1978-01-01 00:00:00

  • Lymphatic vessel density and expressions of lymphangiogenic growth factors in salivary carcinomas.

    abstract::Nodal metastasis is an important prognostic indicator in head and neck cancers, including salivary carcinomas. In these, the risk for lymph node metastasis is variable and strongly associated with the tumor histologic type. The aim of the current study was to evaluate the lymphatic vessel density (LVD) and expressions...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2011_04_331

    authors: Mello MF,Costa AF,Freitas LL,Soares AB,Araujo VC,Tincani AJ,Martins AS,Altemani A

    更新日期:2011-01-01 00:00:00

  • Effect of testosterone on growth of P388 leukemia cell line in vivo and in vitro. Distribution of peripheral blood T lymphocytes and cell cycle progression.

    abstract::In transplanted mice, the P388 tumor grew better in castrated than in non castrated (NC) mice. The proportion of CD8+ in the blood was more numerous in NC mice. The T cell subsets (CD4+ and CD8+) were also high in the mice with small tumor tissue (<10 mg). The correlation observed between the tumor weight and T cell s...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Aboudkhil S,Henry L,Zaid A,Bureau JP

    更新日期:2005-01-01 00:00:00

  • The miR-93 promotes proliferation by directly targeting PDCD4 in hepatocellular carcinoma.

    abstract::Hepatocellular carcinoma (HCC) is the second leading cause of cancer mortality worldwide. Although advances have made in treatment of HCC, the overall survival rate remains low and the molecular pathogenesis of HCC is still poorly understood. The purpose of this study was to explore the molecular pathogenesis of HCC. ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2017_516

    authors: Huang H,Wang X,Wang C,Zhuo L,Luo S,Han S

    更新日期:2017-01-01 00:00:00

  • Primary and transplantable hepatomas induced by aflatoxin B1 in hypothyroid rats.

    abstract::The influence of hypothyroidism on AFB1 carcinogenesis in inbred Wistar rats was studied. The primary AFB1 hepatocarcinogenesis was significantly delayed and reduced. The transplantable hepatomas showed prolonged latency periods in rats of both sexes, and in males decreased tumor weights and a lower number of lung met...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Bednarz W

    更新日期:1989-01-01 00:00:00

  • Histoautoradiographic detection of DNA repair synthesis in mouse liver following dimethylnitrosamine treatment using whole-body application of labeled thymidine.

    abstract::DNA repair synthesis following dimethylnitrosamine (DMN) treatment in mouse liver was detected in vivo by means of histoautoradiography. This phenomenon was more significant around the acinus center (practically in all hepatocytes) than around the portobiliary space. Besides this also a decrease in semiconservative DN...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Hochmann J

    更新日期:1983-01-01 00:00:00

  • Chromosomal anomalies in children treated for cancer.

    abstract::Cytogenetic studies were carried out in peripheral blood lymphocytes of 31 children with cancer (12 retinoblastomas, 9 non-Hodgkin's lymphomas, 7 neuroblastomas and 3 Wilms' tumors) with the purpose of investigating the prevalence and persistence of chromosomal aberrations before onset of antineoplastic treatment and ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: García J,Ruisánchez N,Longchong M,Valdés M,Puig M,Menéndez J,Alert J,Ramos S

    更新日期:1986-01-01 00:00:00

  • Prognostic validation of the WHO 2010 grading system in pancreatic insulinoma patients.

    abstract::The purpose of this study was to evaluate the prognostic potential of the World Health Organization (WHO) 2010 grading system in patients with pancreatic insulinomas. This was a retrospective study that analyzed the overall survival of 85 pancreatic insulinoma patients treated at our Institute between May 2002 and Mar...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2015_058

    authors: Wang L,Yang M,Zhang Y,Xu S,Tian BL

    更新日期:2015-01-01 00:00:00

  • Comparative study of DNA-damaging and DNA-protective effects of selected components of essential plant oils in human leukemic cells K562.

    abstract::Eucalyptol, carvacrol and thymol represent components of plant essential oils characterized by a wide range of biological effects toward microorganisms, fungi, insects, etc. However, till now only a few investigations have been carried out to study the effects of essential oils and their components on human cells cult...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Horvathova E,Turcaniova V,Slamenova D

    更新日期:2007-01-01 00:00:00

  • Prognostic significance of reactive changes in regional lymph nodes in gastric and mammary carcinomas.

    abstract::Regional lymph nodes in 80 cases of gastric and 70 cases of breast cancer have been examined and the reactive types have been correlated to the survival periods of the patients. In both groups of patients, a prognostically favorable sign was the detection of lymphocytic predominance combined with sinus histiocytosis, ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Riegrová D,Jansa P

    更新日期:1982-01-01 00:00:00