Abstract:
:Forty-five thousand three hundred thirteen patients treated in our Institute during the period 1949-1982 were retrospectively analyzed in regard to the appearance of secondary tumors after therapy. Eighty-seven (0.19%) tumors were found, 71 (81.6%) being secondary and 16 (18.4%) simultaneous. Fifty-one (71.8%) tumors were lymphoid, 20 (28.1%) nonlymphoid. Thirty-seven (52.1%) tumors appeared after radiotherapy, 13 (18.3%) after chemotherapy alone. Secondary tumors appeared mostly after 6 years. The prevalence of lymphoid secondary tumors may be explained as a compensatory proliferation of surviving cells progressing to neoplasia. Cytostatics and ionizing radiation as both the initiators and the promoters of malignancy, have besides person's susceptibility a triggering function. From these aspects before any treatment is started all possible carcinogenic factors should be taken into consideration and less carcinogenic procedures with keeping up a full effectiveness should be chosen.
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Svejda J,Lorenz Isubject
Has Abstractpub_date
1985-01-01 00:00:00pages
495-8issue
4eissn
0028-2685issn
1338-4317journal_volume
32pub_type
杂志文章相关文献
NEOPLASMA文献大全abstract::Mitoxantrone, a new anticancer drug has DNA-binding properties similar to anthracycline antibiotics. In the present studies, effect of the drug has been tested in vitro on human chronic myeloid leukemia cells at 37 degrees C and 42 degrees C. Inhibition of 3H-tritiated thymidine incorporation in the drug-treated cells...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1986-01-01 00:00:00
abstract::The goal of this study is to examine whether vitamin D receptor (VDR) polymorphisms are associated with the susceptibility to breast cancer. Meta-analysis was employed to investigate the association between the VDR FokI, BsmI, ApaI, and TaqI polymorphisms and the incidence of breast cancer.A total of 32 comparative st...
journal_title:Neoplasma
pub_type: 杂志文章,meta分析
doi:10.4149/neo_2014_077
更新日期:2014-01-01 00:00:00
abstract::The effect of CMF (cyclophosphamide, methotrexate and 5-fluorouracil) or tamoxifen treatment on endocrine function was investigated in premenopausal and postmenopausal breast cancer patients. CMF therapy resulted in ovarian failure but pituitary and adrenal functions were unaffected in premenopausal patients. Although...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract::Idiopathic granulomatous mastitis (IGM) is a rare inflammatory breast disease mimicking carcinoma and puerperal or non-puerperal mastitis. The primary purpose of this prospectively performed case control study was to compare clinical and imaging signs of IGM with the reference group of nonspecific, non- puerperal mast...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2019_190201N100
更新日期:2019-07-23 00:00:00
abstract::Genetic background of high incidence of spontaneous tumors in BDX rats was investigated with respect to susceptibility to physical or chemical agents and immune response. Percentages of colony forming ability of normal embryo fibroblasts from BDX rats after exposure to various doses of ultraviolet (UV) light, X-rays a...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1986-01-01 00:00:00
abstract::Eighty-eight patients with histologically confirmed colon cancer and two control groups individually matched by age, sex and place of residence, were interviewed about demographic, biosocial and medical variables. The use of laxatives, past history of large bowel disease and coffee consumption for 20 or more years wer...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
abstract::Head and neck squamous cell carcinoma (HNSCC) is a diverse group of cancers that are frequently aggressive in their biologic behavior. Inactivation of tumor suppressor gene (TSG) is one of the most critical steps leading to HNSCC. Loss of heterozygosity analysis is very sensitive method for the detection of frequent a...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract::Cysteine proteinases cathepsin (Cath) B and L and their endogenous inhibitors stefin (Stef) A and B concentrations were measured using a quantitative immunosorbent assay (ELISA; KRKA d.d., Novo mesto, Slovenia) in serum samples from 35 patients with primary and 7 patients with recurrent squamous cell carcinoma of the ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract::Therapeutic cells producing amphotropic retrovirus, which are able to transduce in vivo thymidine kinase gene of Herpes simplex virus were prepared. Single-cell clone cells with high virus productivity (PA-3 17JH5c113) were obtained by cell cloning. The cells were found free of replication competent retrovirus, they w...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract::Cisplatin-based chemotherapy is highly effective in advanced seminoma, but at the cost of a considerable toxicity. The response rate of carboplatin is comparable with cisplatin combinations but the relapse rate is higher. Our study assesses the efficacy and the toxicity of the combination of carboplatin and cyclophosp...
journal_title:Neoplasma
pub_type: 临床试验,杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract::Peroxisome proliferator activated receptor delta (PPARD) is a nuclear receptor transcription factor whose single nucleotide polymorphism (SNP), especially PPARD-87 T>C (rs2016520), may play an important role in expression regulation of PPARD. But its expression patterns as well as contribution in colorectal cancer (CR...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2018_181012N763
更新日期:2019-07-23 00:00:00
abstract::Molecular genetic studies have revealed mutations in a number of oncogenes and tumor suppressor genes in lung cancer. The bcl-2 gene product (bcl-2 protein) is implicated in oncogenesis by its ability to prolong cell death through the inhibition of apoptosis. We investigated expression of bcl-2 in 84 resected human no...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract::Relative content of membrane sectors of ATPase complex in rat liver and Zajdela hepatoma mitochondria and the ability of mitochondrial membrane of the two sources to bind isolated soluble (F1) ATPase were examined. Approximately equal concentrations of oligomycin were required for 50% inhibition of ATPase activity in ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
abstract::DNA-mediated introduction of genes into mammalian cells promises to be a powerful method for detecting sequences that control cell growth, confer resistance to toxic drugs, code for surface receptor proteins, or, indeed alter cell phenotype in any clearly defined way. The identification and molecular cloning of human ...
journal_title:Neoplasma
pub_type: 杂志文章,评审
doi:
更新日期:1995-01-01 00:00:00
abstract::Currently, mechanisms leading to both apoptosis induction and the development of hormone-independence of prostate carcinoma cells are intensively studied. Attention is also given to the possibility of restoring cell sensitivity to hormone-antagonists. The present study focuses on the effect of the combined synthetic c...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract::Some results of the first more complex studies in vitro on radio-sensitizing efficiency, cytotoxicity and reactivity with blood-thiols of a series of 4- or 5-nitroimidazoles substituted in the 5, 4 or 2 position with chlorine are presented. The derivatives of 4-nitroimidazole substituted in 5 position ("ortho" positio...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
abstract::During the years 1973-1987, 75 patients were irradiated for brain metastases of unknown origin at the Institute of Oncology in Ljubljana. Of these, 35 (47%) were previously treated by surgery: Metastases were completely removed in 22 patients and partially in 7, whereas biopsy alone was performed in 6 patients. Based ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
abstract:UNLABELLED:Results of radiochemotherapy in 50 patients with squamous cell carcinoma of the anal canal, treated with radical radiochemotherapy between January 2003 and September 2007, at the Institute of Oncology Ljubljana are presented. The treatment schedule consisted of 3-D conformal external beam radiotherapy (45 Gy...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2009_02_150
更新日期:2009-01-01 00:00:00
abstract::A series of seven monoclonal antibodies recognizing cell surface antigens of similar distribution on a panel of leukemia/lymphoma and lymphoblastoid human cell lines was prepared by hybridoma technique after immunization with non-T, non-B acute lymphoblastic leukemia cell line REH. Immune reactivity of these monoclona...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract::The aim of the present retrospective study was to evaluate the prognostic significance of epidermal growth factor receptor (EGFR) expression in patients treated with radiotherapy or concomitant chemoradiotherapy for squamous cell anal cancer (SCAC)Patients and methods: A total of 17 patients with SCAC (clinical stages...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/313_150913N485
更新日期:2016-01-01 00:00:00
abstract::Cytogenetic studies in Chinese hamster ovary (CHO) cells using aqueous and organic extracts of pan masalas, as well as genomic damage observed among pan masala consumers have conclusively shown genotoxic potential of pan masala-a dry complex mixture of areca nut, lime, catechu, cardamom, unspecified flavoring agent, e...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::The humoral and cellular immune status of C57BL/6 male mice and "R" male rats bearing MC-induced sarcomas were investigated in vitro, using 51Cr-releasing and mixed hemadsorption assays. Analysis was performed on mice subjected to concomitant tumor immunity (CTI) model experiments or bearing primary tumors of differen...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1977-01-01 00:00:00
abstract::Drug resistance is a prominent problem of cancer therapy. Differences in quantity and quality of many metabolites in normal and malignant cells and their changes after treatment by anticancer drugs can be detected by nuclear magnetic resonance (NMR) both in vivo and in vitro. The results of in vivo and in vitro 1H, 13...
journal_title:Neoplasma
pub_type: 杂志文章,评审
doi:
更新日期:1998-01-01 00:00:00
abstract::The clinical significance of thymosin β4 (Tβ4) expression in bladder transitional cell carcinoma (BTCC) remains unclear. The present study assessed the relationship between the expression of Tβ4 protein and the clinicopathological features, as well as the prognosis of bladder cancer patients. Tβ4 protein expression in...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2016_619
更新日期:2016-01-01 00:00:00
abstract::There is some evidence that prostaglandin (PGE)-secreting cells may have a role in immunosuppression in cancer patients. In this work we investigated the effects of indomethacin--a PGE synthesis inhibitor, on PHA-induced lymphoproliferative response in vitro. Twenty patients with lung cancer before therapy were includ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract::Activity of chromatin-bound protease of rat liver and Morris hepatoma 7777 was studied. Proteolytic enzyme was copurified with histones during extraction of chromatin with 0.25 M HCl. Total histone was fractionated by Oliver's et al. method. Histone fractions were incubated in 0.01 M Tris-HCl buffer (pH 7.6) at 37 deg...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1980-01-01 00:00:00
abstract::Comparative studies on the presence and immunological reactivity of CEA and CEA-like antigens in lung and digestive tract cancers were performed. Specific goat and rabbit anti-CEA immune sera were used. Immunofluorescence studies revealed in histologically different types of the lung carcinomas the presence of the cro...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
abstract::The purpose of the present paper was to demonstrate the antitumor activity of lymphocytes and antibodies in the antibody-dependent cell-mediated cytotoxicity test (ADCC) in relation to the tumor growth in adult and aging rats bearing a methylcholanthrene-induced sarcoma (MC-Sa). In the syngeneic system using the ADCC ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
abstract::The results of treatment of acute promyelocytic leukemia, when combination ATRA + chemotherapy is used in induction and maintainance therapy and risk adapted strategy applied in consolidation, improved at present time. Enhanced supportive therapy also contribute to improved outcome of APL patients. 3 - year relapse fr...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2010_03_270
更新日期:2010-01-01 00:00:00
abstract::Melanoma is a malignant tumor. The acquisition of stemness of melanoma cells aggravates the malignant transformation, which can be regulated by microRNAs (miRNAs, miR). MiR-363-3p is a key tumor-related miRNA, but its role in stemness and melanoma cells is still unknown. Presently, miR-363-3p, induced by hypoxia induc...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2018_180828N655
更新日期:2019-05-23 00:00:00