Effect of mitoxantrone on human chronic myeloid leukemia cells in vitro, combined with hyperthermia.

Abstract:

:Mitoxantrone, a new anticancer drug has DNA-binding properties similar to anthracycline antibiotics. In the present studies, effect of the drug has been tested in vitro on human chronic myeloid leukemia cells at 37 degrees C and 42 degrees C. Inhibition of 3H-tritiated thymidine incorporation in the drug-treated cells compared with untreated cells has been used as the parameter of cytotoxicity of the drug and hyperthermia. Cell samples from 11 CML patients who did not receive any chemotherapy showed less response to the drug at 0.5 micrograms/ml and 1 microgram/ml at 37 degrees C. Exposure of CML cells to 42 degrees C for 2 h indicated 13 to 44% inhibition in 3H-TdR incorporation. However, when CML cells were exposed to mitoxantrone for 2 h at 42 degrees C the 3H-thymidine incorporation was inhibited to the extent of 27 to 71%, indicating greater cellular damage with this combination.

journal_name

Neoplasma

journal_title

Neoplasma

authors

Juvekar AS,Chitnis MP,Adwankar MK,Advani SH

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

477-82

issue

4

eissn

0028-2685

issn

1338-4317

journal_volume

33

pub_type

杂志文章
  • Natural cell-mediated cytotoxicity in Ehrlich ascites tumor-bearing mice.

    abstract::The level of NCMC (natural cell-mediated cytotoxicity) in the spleen of Ehrlich ascites tumor-bearing mice at every 5 days after i. p. tumor transplantation, and the effect of cell-free ascitic fluid or serum of tumor bearers on natural cytotoxicity in vitro, were assessed. Spleen lymphocytes were used as effectors an...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Olinescu A,Hristescu S,Mazilu E

    更新日期:1983-01-01 00:00:00

  • Factors influencing circulating MicroRNA level in the studies of hepatocellular carcinoma biomarker.

    abstract::Factors influencing circulating miRNA as a diagnostic marker of hepatocellular carcinoma (HCC) are still unknown. We used two kits to extract total RNA of 90 paired serum and plasma samples of volunteers in different statuses including healthy, hepatitis, cirrhosis and HCC. U6, miR-183 and cel-miR-39 expression levels...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2015_096

    authors: Wang Y,Liang Z,Gao Y,Zhai D,Rao Q,Shi W,Yang B,Jing L,Guo H,Liu T,Liu J,DU Z

    更新日期:2015-01-01 00:00:00

  • Suppressing the secretion of exosomal miR-19b by gw4869 could regulate oxaliplatin sensitivity in colorectal cancer.

    abstract::Oxaliplatin is commonly used in managing malignancy, including colorectal cancer. While treatment often fails due to decreased drug sensitivity, the mechanisms involved are not clear. In this study, we investigate how exosomal miR-19b participates in oxaliplatin sensitivity and then prove that miR-19b down-regulates o...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2018_180306N155

    authors: Gu YY,Yu J,Zhang JF,Wang C

    更新日期:2019-01-15 00:00:00

  • Relation between the chemical structure and acute toxicity of 1-phenyl-3-methyltriazenes as activated metabolites during the carcinogenic action of 1-phenyl-3,3-dimethyltriazenes.

    abstract::The mol LD50 values were correlated with Hammett sigma constants in terms of the Hansen empiric equation 6 for para substituted derivatives of 1-phenyl-3-methyltriazene. Good agreement was achieved and the line slope of the correlation, 0.3, is the same as that found during an identical experiment with derivatives of ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Matrka M,Rambousek V,Zvĕrina V

    更新日期:1978-01-01 00:00:00

  • Cytophotometric and cytogenetic characteristics of primary hepatomas induced in Wistar rats by aflatoxin B1.

    abstract::Karyograms of the primary hepatomas induced in Wistar rats by aflatoxin b1 exhibited hypodiploid chromosome sets, and destruction of the chromosomes. Cytophotometric investigations showed a decrease of DNA content in the neoplastic cells, even to about 40% of DNA content in the normal hepatocytes in rats. In the neopl...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Gasiorowski K,Zawirska B

    更新日期:1981-01-01 00:00:00

  • Circulating immune complexes in Hodgkin's disease. Reactivity of IgG isolated from circulating immune complexes.

    abstract::In our earlier report on circulating immune complexes (CIC) from sera of patients with Hodgkin's disease (HD), we demonstrated disease-associated increase in the intensity of a 40kD (pl 5.6) polypeptide in the CIC. In extension of these investigations, we now report that the 40kD moiety exists in CIC as a complex with...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Nerurkar AV,Advani SH,Gothoskar BP

    更新日期:1993-01-01 00:00:00

  • In vitro and in vivo studies of antitumor effects of the recombinant immunotoxin MSH-PE38KDEL on melanoma.

    abstract::MSH-PE38KDEL is a chimeric molecule composed of MSH, and fused to a truncated mutant form of Pseudomonas exotoxin (PE38KDEL). Our study aims to evaluate the specific cytotoxicity of recombinant immunotoxin MSH-PE38KDEL on melanoma cells A875 and B16 in vitro, as well as its inhibition of metastatic melanoma in vivo. M...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2014_048

    authors: Hui Q,Ma J,Song J,Liu Z,Ren H,Jiang W,Wang Y,Xu Y,Guo D,Zhang X,Lu S

    更新日期:2014-01-01 00:00:00

  • Cathepsin B and L and stefin A and B levels as serum tumor markers in squamous cell carcinoma of the head and neck.

    abstract::Cysteine proteinases cathepsin (Cath) B and L and their endogenous inhibitors stefin (Stef) A and B concentrations were measured using a quantitative immunosorbent assay (ELISA; KRKA d.d., Novo mesto, Slovenia) in serum samples from 35 patients with primary and 7 patients with recurrent squamous cell carcinoma of the ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Strojan P,Budihna M,Smid L,Svetic B,Vrhovec I,Skrk J

    更新日期:2001-01-01 00:00:00

  • The antitumor activity of oxoplatinum.

    abstract::A coordination complex cis-dichlorodiamminedihydroxoplatinum (IV) (oxoplatinum) was first synthesized in the USSR by Chugaev and Khlopin in 1927 [3]. Its marked antitumor properties were revealed by one of the authors of this article at the All-Union Cancer Research Center of the Academy of Medical Sciences of the USS...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Presnov MA,Konovalova AL,Kozlov AM,Brovtsyn VK,Romanova LF

    更新日期:1985-01-01 00:00:00

  • Ovarian and endometrial endometrioid carcinoma: diagnostic implications of flow cytometry.

    abstract::Surgical specimens from two patients with simultaneously occurring ovarian and endometrial endometrioid carcinoma were studied by flow cytometry (FCM) and routine histological examination. Tissue derived from the uterine and the ovarian lesion showed similar FCM curves in each case. The information obtained from FCM w...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Vassilev NB,Christov KT,Raychev RD

    更新日期:1986-01-01 00:00:00

  • A pilot study testing the genetic polymorphism of N-acetyltransferase 2 as a risk factor in lung cancer.

    abstract::NAT2 as phase II enzyme is involved in the detoxification/activation of various drugs, environmental substances and carcinogenic compounds. A genotyping approach has been used to investigate NAT2 genotype with putative relevance in lung cancer in population of 110 Slovak-Caucasians patients and 167 non-malignant indiv...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Habalová V,Salagovic J,Kalina I,Stubna J

    更新日期:2005-01-01 00:00:00

  • Clastogenic effects of N-nitrosodimethylamine and dinitrosoglycolurile in murine bone marrow cells and cow lymphocytes.

    abstract::The clastogenic effects of N-nitrosodimethylamine (N-DMA) and dinitrosoglycolurile (DNSGU) were studied in the bone marrow of mice and in peripheral blood lymphocytes of cows. None of the tested compounds showed significant enhancement of chromosome aberrations at doses 1/2 LD50 and 1/10 LD50 in murine bone marrow cel...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Siviková K

    更新日期:1994-01-01 00:00:00

  • Distribution and photodynamic effect of zinc phthalocyanine disulfonate in nude mice bearing mammary carcinoma.

    abstract::The distribution study of zinc phthalocyanine disulfonate (ZnPcS2) in nude mice bearing mammary carcinoma (T50/80) revealed a rapid uptake of the dye by tumor. In experimental photodynamic therapy (PDT), the tumors were exposed to laser radiation (670 nm, 100 mW/cm2, 150 J/ /cm2) after intravenous administration of Zn...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Mosa M,Zitko M,Poucková P

    更新日期:1997-01-01 00:00:00

  • BioBran-augmented maturation of human monocyte-derived dendritic cells.

    abstract:UNLABELLED:BioBran, enzymatically modified arabinoxylan from rice bran was tested for its possible effects on in vitro maturation of human dendritic cells (DC). Immature DC (iDC) derived from plastic-adhered, IL-4 and GM-CSF treated peripheral monocytes (Mo) were further cultured with cytokine maturation mix 1 (CMM1; T...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2009_02_89

    authors: Cholujova D,Jakubikova J,Sedlak J

    更新日期:2009-01-01 00:00:00

  • Human mammary gland associated antigens. Lack of D-type retravirus-induced antigens.

    abstract::Antisera against tumor-associated and organ-specific antigens of human mammary glands, as well as mammary carcinoma patient sera were used in cross-reactions with the test-system for a nucleoid antigen of Hep-2 retravirus. None of the antigens, revealed in mammary carcinomas and human milk seems to be either viral str...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Kryukova IN,Bobrova TS

    更新日期:1977-01-01 00:00:00

  • Bilateral breast cancer.

    abstract::The aim of this study was to evaluate the clinical and pathological features of breast cancer patients with bilateral breast cancer and to assess the impact of the second breast cancer on their prognosis. Thirty six breast cancer patients with bilateral (metasynchronous) cancer were treated in Greatpoland Cancer Cente...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Skowronek J,Piotrowski T

    更新日期:2002-01-01 00:00:00

  • The potential roles of vesicle-enclosed miRNAs in communication between macrophages and cancer cells in tumor microenvironment.

    abstract::Functional microRNA (miRNA) molecules are transported in extracellular vesicles among tumor cells and cells of the immune system. Macrophages as integral components of tumor microenvironment are known as potential contributors to tumor growth and progression. We searched for studies which could provide a direct link b...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2017_311

    authors: Korabecna M,Koutova L,Tesarova P

    更新日期:2017-01-01 00:00:00

  • Iron-tumor cell interaction and regulation of Ca2+ homeostasis: their implication in tumor growth.

    abstract::Using [59Fe] ferric lactate, a direct relationship between iron concentration and [59Fe] uptake by Ehrlich ascites tumor cells was found. Deferoxamine and albumin inhibited this uptake. Electrophoresis showed that both molecules complexed iron from ferric lactate. [45Ca] uptake in the presence of ferric lactate showed...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Anghileri LJ,Martinez AC,Maleki P

    更新日期:1992-01-01 00:00:00

  • MicroRNA-584-3p reduces the vasculogenic mimicry of human glioma cells by regulating hypoxia-induced ROCK1 dependent stress fiber formation.

    abstract::We report in this study that microRNA-584-3p (miR-584-3p) is related to the vasculogenic mimicry (VM) of human glioma cells. Unsurprisingly, the postoperative survival time was significantly prolonged in those glioma patients without VM phenomena compared with those with positive VM. miR-584-3p may function as a poten...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2017_102

    authors: Xu S,Zhang J,Xue H,Guo X,Han X,Li T,Guo X,Gao X,Liu Q,Li G

    更新日期:2017-01-01 00:00:00

  • Potential carcinogenic and inhibitory activity of compounds isolated from Lilium candidum L.

    abstract::This paper deals with determination of potential carcinogenic and inhibitory activity of 10 compounds isolated from the ethanolic extract of Lilium candidum L. perfonned by DC polarography. The series of investigated compounds consisted of two spirostanol saponins, two pyroline derivatives, jatropham and its glucoside...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Vachálková A,Eisenreichová E,Haladová M,Mucaji P,Józová B,Novotný L

    更新日期:2000-01-01 00:00:00

  • Second line treatment in advanced non-small cell lung cancer (NSCLC): comparison of efficacy of erlotinib and chemotherapy.

    abstract::Molecular targeted therapy based on tyrosine kinase inhibitors, directed at the epidermal growth factor receptor (EGFR) is one of novel options for management of NSCLC. Erlotinib is EGFR tyrosine kinase inhibitor used for treatment of the advanced NSCLC. This presented study is focused on comparison of erlotinib and c...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2013_017

    authors: Fiala O,Pesek M,Finek J,Krejci J,Bortlicek Z,Benesova L,Minarik M

    更新日期:2013-01-01 00:00:00

  • Inhibition of colony-forming cells from bone marrow of leukemic patients by 3-oxauracil.

    abstract::An in vitro system of colony forming cell inhibition was used for evaluation of 3-oxauracil (2,3-dihydro-1,3-6H-oxazine-2,6-dione) effectivity against bone marrow cells from 18 leukemic patients. The highest inhibitive activity of the 3-oxauracil was found in cases of acute lymphoblastic leukemia, comparing with bone ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Reiner P,Mardiak J,Reinerová M,Ujházy V

    更新日期:1981-01-01 00:00:00

  • Factors influencing outcome of surgery for stage I rectal cancer.

    abstract::Stage I rectal cancer (T1N0M0, T2N0M0) carries excellent prognosis with up to 90% of long term survival rates and complete cure can be expected with curative surgery. However 10 to 15% of these patients show local recurrence and mortality seen in five years. The aim of this study is to analyze the prognostic factors t...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Celen O,Yildirim E,Berberoglu U

    更新日期:2004-01-01 00:00:00

  • Loss of neuropilin1 inhibits liver cancer stem cells population and blocks metastasis in hepatocellular carcinoma via epithelial-mesenchymal transition.

    abstract::It is generally believed that the existence of cancer stem cells (CSCs) is related to tumor recurrence and metastasis of hepatocellular carcinoma (HCC). Neuropilin1 (NRP1) is involved in numerous pathophysiological processes of tumor progression, however, whether NRP1 is involved in the regulation of liver CSCs and me...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2020_200914N982

    authors: Li X,Zhou Y,Hu J,Bai Z,Meng W,Zhang L,Song X,Wei Y,Yan J,Zhou Y

    更新日期:2020-12-23 00:00:00

  • Quadruple cancer, including triple cancers in the head and neck region.

    abstract::Multiple primary tumors are not rare: they are encountered in 3-5% of malignant tumors. They are particularly frequent in the head and neck [20]. They are most often met with secondary malignant tumors; triple tumors occur in only 0.5%, quadruple tumors in 0.3% of malignant tumors. The possibility of developing a seco...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Németh Z,Czigner J,Iván L,Ujpál M,Barabás J,Szabó G

    更新日期:2002-01-01 00:00:00

  • Comparison of methods used to study cell death in an adherent tumoral cell line with moderate clonogenic radiosensitivity.

    abstract::Our objective was to compare different methods for studying programmed cell death in adherent H460 non-small lung cancer cells of moderate clonogenic radiosensitivity. The major effect of gamma-radiation was found to be the release of cells from the substratum. The different methods gave complementary and unexpected i...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Broquet P,Rodriguez-Lafrasse C,Alphonse G,Aloy MT,Louisot P,Rousson R

    更新日期:2001-01-01 00:00:00

  • Deletion mapping of chromosome 4q22-35 and identification of four frequently deleted regions in head and neck cancers.

    abstract::Head and neck squamous cell carcinoma (HNSCC) is a diverse group of cancers that are frequently aggressive in their biologic behavior. Inactivation of tumor suppressor gene (TSG) is one of the most critical steps leading to HNSCC. Loss of heterozygosity analysis is very sensitive method for the detection of frequent a...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Cetin E,Cengiz B,Gunduz E,Gunduz M,Nagatsuka H,Bekir-Beder L,Fukushima K,Pehlivan D,N MO,Nishizaki K,Shimizu K,Nagai N

    更新日期:2008-01-01 00:00:00

  • Sensitivity of TSTA and species-specific cell membrane antigens of tumor cells to glutaraldehyde treatment.

    abstract::In vivo immunogenicity and in vitro species-specific membrane antigens in tumor cells treated or untreated with glutaraldehyde (GA) were studied. Two different syngeneic Syrian hamster transplantable tumor cell lines (spontaneous liver cancer and SV40-induced sarcoma) not only lost immunogenicity after GA treatment bu...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Kluchareva TE,Matveeva VA,Deichman GI

    更新日期:1978-01-01 00:00:00

  • Individual-level data on the relationships of progression-free survival, post-progression survival, and tumor response with overall survival in patients with advanced non-squamous non-small cell lung cancer.

    abstract::The effects of first-line chemotherapy on overall survival (OS) might be confounded by subsequent therapies in patients with non-small cell lung cancer (NSCLC). We examined whether progression-free survival (PFS), post-progression survival (PPS), or tumor response could be valid surrogate endpoints for OS after first-...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2014_030

    authors: Imai H,Takahashi T,Mori K,Ono A,Akamatsu H,Shukuya T,Taira T,Kenmotsu H,Naito T,Murakami H,Endo M,Nakajima T,Yamamoto N

    更新日期:2014-01-01 00:00:00

  • Identification of differential proteins in colon cancer SW480 cells with HIF1-alpha silence by proteome analysis.

    abstract::Hypoxia is one of the basic characteristics of the colorectal cancer and HIF1 plays a central role in tumor hypoxia adaptation and controls the expression of a variety of genes. But it had not reached a comprehensive understanding of them in colorectal cancer in hypoxia. This study silenced HIF1-alpha, which is the re...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2010_04_299

    authors: Wu XY,Fu ZX,Wang XH,Shen W

    更新日期:2010-01-01 00:00:00