Abstract：
:Drug resistance is a prominent problem of cancer therapy. Differences in quantity and quality of many metabolites in normal and malignant cells and their changes after treatment by anticancer drugs can be detected by nuclear magnetic resonance (NMR) both in vivo and in vitro. The results of in vivo and in vitro 1H, 13C, 19F and 31P NMR spectroscopy and their correlation with the degree of resistance to anticancer drugs are discussed. Monitoring of treatment and development of drug resistance by this non-invasive method could be useful not only in cancer research related to drug resistance but also in clinical medical oncology.
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Hanusovská E,Dovinová I,Tkác I,Novotný Lsubject
Has Abstractpub_date
1998-01-01 00:00:00pages
187-97issue
4eissn
0028-2685issn
1338-4317journal_volume
45pub_type
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