Expression profile of long noncoding RNAs in human papillary thyroid carcinoma.

Abstract:

:Long non-coding RNAs (lncRNAs) are strongly associated with cancer biology. The objective of this study is to investigate the expression profile of lncRNAs in human papillary thyroid carcinoma (PTC), and to understand the biological role of lncRNAs and their involvement in PTC oncogenesis. The lncRNAs and messenger RNAs (mRNAs) expression in human PTC and paired adjacent non-cancerous thyroid (NCT) tissues were studied by micro-array, and quantitative real-time polymerase chain reaction (qRT-PCR) validated five differentially expressed lncRNAs. We identified 2,925 significantly differentially expressed lncRNAs with potential roles in PTC, (absolute fold change >2.0; p<0.05). Of these, 1,922 were up-regulated and 933 down-regulated and the qRT-PCR results agreed with micro-array results. Gene ontology (GO) enrichment and pathway analysis then investigated gene function and identified significantly enriched pathways in differentially expressed mRNA's. Many of these pathways were related to cancer, including 60 genes associated with "pathways in cancer" and 34 linked to "proteoglycans in cancer". Co-expression network and target prediction analysis of lncRNAs revealed that TCONS_00020457 can have important roles in PTC. In conclusion, the results of this study indicate that lncRNAs can be important regulators in PTC tumorigenesis and provide understanding of the function and mechanism of lncRNAs related to human papillary thyroid carcinoma.

journal_name

Neoplasma

journal_title

Neoplasma

authors

Cao Y,Shi C,Li J,Liang Y,Qiu J,Yuan L,Yong Z,Zhang DX,Shi GQ

doi

10.4149/neo_2018_180625N414

subject

Has Abstract

pub_date

2019-03-05 00:00:00

pages

245-251

issue

2

eissn

0028-2685

issn

1338-4317

pii

180625N414

journal_volume

66

pub_type

杂志文章
  • Effect of inhibition of DNA synthesis on recovery of X-irradiated L5178Y-S cells, II. 9-beta-D-arabinofuranosyladenine.

    abstract::The effects of 9-beta-D-arabinofuranosyladenine (araA) on radiosensitivity, postirradiation changes in the cell cycle distribution and DNA synthesis in mouse L5178Y-S lymphoma cells are described. Increase in the araA concentration (from 25 to 200 mumol/l) was is correlated with reduction in clonogenic survival except...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Kapiszewska M,Lange CS

    更新日期:1989-01-01 00:00:00

  • The role of radiation therapy in the treatment of cancer of the prostate.

    abstract::The review of the literature assessing the value of external radiotherapy in treatment of patients with prostatic cancer is presented. Radiotherapy appears to be the curative treatment since about 55% of 10 years symptoms free survival rate can be achieved in stages A and B and 35% in stage C. The results of radiother...

    journal_title:Neoplasma

    pub_type: 杂志文章,评审

    doi:

    authors: Korzeniowski S

    更新日期:1988-01-01 00:00:00

  • Prognostic significance of plasma cell propidium iodide and annexin-V indices and their mutual ratio in multiple myeloma.

    abstract::The aim of this study was a contemporaneous measurement of plasma cells proliferative and apoptotic activity in patients examined at the time of multiple myeloma (MM) diagnosis before initiation of chemotherapy, focussed on the following aspects: determination of prognostic significance of plasma cell propidium iodide...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Scudla V,Ordeltova M,Minarik J,Dusek L,Zemanova M,Bacovsky J

    更新日期:2006-01-01 00:00:00

  • Radiation treatment for ductal carcinoma in situ (DCIS): is a boost to the tumor bed necessary?

    abstract::The aim of the presented study was to evaluate the long-term outcome of breast-conserving surgery and radiation for the treatment of ductal carcinoma in situ (DCIS) and the role of the radiation boost to the tumor bed. The files of 75 women with DCIS treated by breast-conserving surgery followed by definitive radiatio...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Yerushalmi R,Sulkes A,Mishaeli M,Neumann A,Dinerman M,Sulkes J,Rizel S,Yarom N,Gutman H,Fenig E

    更新日期:2006-01-01 00:00:00

  • Sacharose density gradient separation of Ehrlich ascites carcinoma and L-5178Y tumor cells in different cell cycle phases.

    abstract::Optimal conditions were determined for the distribution of Ehrlich ascites carcinoma (EAC) and L-5178Y mouse tumor cells, proliferating in vivo, by their age within the cell cycle by sedimentation in a buffered linear sacharose density gradient. Measurements of cell size, DNA content and incorporation of tritiated thy...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Horáková K,Fusková A,Ceglédyová N

    更新日期:1976-01-01 00:00:00

  • Evaluation of carcinoembryonic antigen (CEA) and brain-type creatine kinase (CK-BB) in serum from patients with carcinoma of the lung.

    abstract::The levels of carcinoembryonic antigen (CEA) and the activities of creatine kinase isoenzyme BB (CK-BB) were assessed in 84 patients with primary lung carcinoma and in 20 patients with nonmalignant lung diseases. The level of CEA was measured by the immunoenzymatic method using monoclonal antibodies (Abbott). The acti...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Nikliński J,Furman M,Laudański J,Pałynyczko Z,Welk M

    更新日期:1991-01-01 00:00:00

  • Nonmelanoma skin cancers and risk of subsequent malignancies: a cancer registry-based study in Bulgaria.

    abstract::Analysis of new primary tumors following nonmelanoma skin cancers (NMSC) has a public health and risk assessment interest, as well as potential implications for etiologic inference. The aim of this study is to evaluate the risk of the second primary tumors occurrence after NMSC development. A cohort of 2620 cases (133...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Troyanova P,Danon S,Ivanova T

    更新日期:2002-01-01 00:00:00

  • Host-tumor relationship XXXIII. Inhibitor of hyaluronidase in blood serum of cancer patients.

    abstract::Inhibiting activity of blood serum was determined from the decrease of N-acetyl-hexosamine end groups of hyaluronic acid products released by testicular hyaluronidase. Maximum inhibition was observed within the region of pH from 6.5 to 6.8. Correlation between the serum concentration and its inhibiting effect on hyalu...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Kolárová M

    更新日期:1975-01-01 00:00:00

  • Results of radiotherapy and combined radiotherapy and chemotherapy of inoperable lung cancer.

    abstract::In this study there is presented a comparative analysis of immediate results after radiotherapy and combined treatment (radio- and chemotherapy) in 174 patients with highly differentiated inoperable lung cancer. The data were provided by participants of a joint investigation in some CMEA member countries (Hungary, USS...

    journal_title:Neoplasma

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Kiseleva ES,Pitskhelauri VG,Trakhtenberg AK,Daryalova SL,Kasyanenko IV,Zakharchenkov AV,Lebedev VA,Zvekotkina LS,Glagolev AN,Bidyak IP

    更新日期:1983-01-01 00:00:00

  • Influence of "nuclear" estrogen receptor content on prognosis of early stage carcinoma of the uterine body. A short-time follow-up.

    abstract::Sixty-five patients with Stage I and II endometrial carcinoma were investigated. After a short-time follow-up (17-24 months) significant differences in frequency of relapses were observed between patients with tumors containing low amounts of estrogen receptor (ER less than 60 fmol/mg DNA) in the nuclear pellet, and t...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Horvath G,Johnsson JE,Tropé C,Samuelsson L,Alm P,Olsson H

    更新日期:1990-01-01 00:00:00

  • Individual-level data on the relationships of progression-free survival, post-progression survival, and tumor response with overall survival in patients with advanced non-squamous non-small cell lung cancer.

    abstract::The effects of first-line chemotherapy on overall survival (OS) might be confounded by subsequent therapies in patients with non-small cell lung cancer (NSCLC). We examined whether progression-free survival (PFS), post-progression survival (PPS), or tumor response could be valid surrogate endpoints for OS after first-...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2014_030

    authors: Imai H,Takahashi T,Mori K,Ono A,Akamatsu H,Shukuya T,Taira T,Kenmotsu H,Naito T,Murakami H,Endo M,Nakajima T,Yamamoto N

    更新日期:2014-01-01 00:00:00

  • Inhibition of colony-forming cells from bone marrow of leukemic patients by 3-oxauracil.

    abstract::An in vitro system of colony forming cell inhibition was used for evaluation of 3-oxauracil (2,3-dihydro-1,3-6H-oxazine-2,6-dione) effectivity against bone marrow cells from 18 leukemic patients. The highest inhibitive activity of the 3-oxauracil was found in cases of acute lymphoblastic leukemia, comparing with bone ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Reiner P,Mardiak J,Reinerová M,Ujházy V

    更新日期:1981-01-01 00:00:00

  • The current look at high-dose chemotherapy in breast cancer minireview.

    abstract::High-dose chemotherapy (HDC) in high-risk breast cancer is one of the possible approaches how to improve therapeutic results, eventually, to overcome the incurability of the disease. In recent randomized studies superiority of HDC to conventional therapy has not been unambiguously established. Nevertheless, many oncol...

    journal_title:Neoplasma

    pub_type: 杂志文章,评审

    doi:

    authors: Filip S,Petera J,Odrázka K,Bláha M

    更新日期:2000-01-01 00:00:00

  • Lymphatic vessel density and expressions of lymphangiogenic growth factors in salivary carcinomas.

    abstract::Nodal metastasis is an important prognostic indicator in head and neck cancers, including salivary carcinomas. In these, the risk for lymph node metastasis is variable and strongly associated with the tumor histologic type. The aim of the current study was to evaluate the lymphatic vessel density (LVD) and expressions...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2011_04_331

    authors: Mello MF,Costa AF,Freitas LL,Soares AB,Araujo VC,Tincani AJ,Martins AS,Altemani A

    更新日期:2011-01-01 00:00:00

  • Analysis of ceRNA network identifies prognostic circRNA biomarkers in bladder cancer.

    abstract::Bladder cancer remains a very challenging disease to treat with the high rates of recurrence and progression associated with current therapies. Although the association between bladder cancer pathology and circRNAs remains undetermined, circRNAs signatures may be useful as prognostic and predictive factors and clinica...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2019_190107N25

    authors: Liu L,Wu SQ,Zhu X,Xu R,Ai K,Zhang L,Zhao XK

    更新日期:2019-06-03 00:00:00

  • Clinical significance of the plasminogen activator system in relation to grade of tumor and treatment response in colorectal carcinoma patients.

    abstract::Urokinase (uPA) plays an essential role in the activation of plasminogen to plasmin, and together with its receptor (uPAR), tissue activator (tPA) and urokinase inhibitors (PAI 1, PAI 2, PAI 3 and protease nexin) forms the plasminogen activator system (PAS), a component of metastatic cascade importantly contributing t...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2011_05_377

    authors: Halamkova J,Kiss I,Pavlovsky Z,Tomasek J,Jarkovsky J,Cech Z,Tucek S,Hanakova L,Moulis M,Zavrelova J,Man M,Benda P,Robek O,Kala Z,Penka M

    更新日期:2011-01-01 00:00:00

  • Management of germ cell testicular cancer with pulmonary metastases.

    abstract::Twenty eight patients with germ cell testicular cancer pulmonary metastases received primary chemotherapy including bleomycin, etoposide, and cisplatin (BEP). Complete response was achieved in 21 (75%) patients, in 11 of them CR was achieved following chemotherapy alone. Postchemotherapy surgery of residual mass was p...

    journal_title:Neoplasma

    pub_type: 临床试验,杂志文章

    doi:

    authors: Schnorrer M,Ondrus D,Cársky S,Hornák M,Belan V,Kausitz J,Matośka J

    更新日期:1996-01-01 00:00:00

  • An iso-effect table for radiation tolerance of the human thoracic spinal cord. A new approach on the basis of the DFT conception.

    abstract::Forty-four cases of well documented progressive radiation myelopathy of thoracic spinal cord were analyzed in terms of the new DFT conception (Dose-Fraction-Time). The DFT conception is a new radiobiological cell tissue kinetic model comprising explicitly repopulation. The conception has been previously tested against...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Vodvárka P,Kozubek S

    更新日期:1986-01-01 00:00:00

  • Light and electron microscopy of mouse lymphosarcoma LS/BL cells during the first hour after irradiation with x-rays.

    abstract::Mouse lymphosarcoma LS/BL cells growing in tissue culture were irradiated with 100, 316 and 1000 R respectively and fixed 5, 15 or 60 minutes later. Semithin sections were studied under a light and ultrathin under an electron microscopes. Under the light microscope, differences between the morphology of individual nuc...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Tkadlecek L,Karpfel Z,Cibulka M,Viklická S,Spurná V

    更新日期:1975-01-01 00:00:00

  • Synergic effects of the cyclin-dependent kinase (CDK) inhibitor olomoucine and androgen-antagonist bicalutamide on prostatic cancer cell lines.

    abstract::Currently, mechanisms leading to both apoptosis induction and the development of hormone-independence of prostate carcinoma cells are intensively studied. Attention is also given to the possibility of restoring cell sensitivity to hormone-antagonists. The present study focuses on the effect of the combined synthetic c...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Knillová J,Bouchal J,Hlobilková A,Strnad M,Kolár Z

    更新日期:2004-01-01 00:00:00

  • Medroxyprogesterone acetate versus tamoxifen in the therapy of advanced breast cancer.

    abstract::A comparison of efficacies of medroxyprogesterone acetate (MPA) and the antiestrogen tamoxifen (TX) in the therapy for advanced breast cancer in patients who had already previously been intensely treated showed that, as to the objective remissions, the two drugs can be looked upon as equivalent. Nevertheless, with MPA...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Lorenz I,Mechl Z

    更新日期:1985-01-01 00:00:00

  • Flow cytometric analysis of primary cervical and vulvar carcinomas and their metastases.

    abstract::In a series of 25 patients with cervical carcinoma and 35 patients with vulvar carcinoma, clinically classified (FIGO) as Stage I and Ib, respectively, DNA ploidy and S-phase cell fraction were estimated in paraffin-embedded samples of the primary tumors and their metastases by means of flow cytometry (FCM). The two g...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Siracký J,Kysela B,Siracká E

    更新日期:1989-01-01 00:00:00

  • Flavonoids potentiate the efficacy of cytarabine through modulation of drug-induced apoptosis.

    abstract::Recent studies have provided strong evidence for potential beneficial effects of flavonoids in chemoprevention or in combination with chemotherapeutics in tumor cells treatment. The aim of this work was to compare the antioxidant properties of four flavonoids with emphasis on association of these antioxidant propertie...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Nadova S,Miadokova E,Cipak L

    更新日期:2007-01-01 00:00:00

  • Radiosensitizer AK-2123 as modulating agent in the chemotherapy of experimental metastases.

    abstract::Therapeutic effect of Cyclophosphamide (CPA) and radiosensitizer AK-2123 (AK) combination versus CPA alone in the same doses was investigated on transplanted LL carcinoma and B 16 melanoma. Antimetastatic efficacy of different doses of CPA and combined therapy was evaluated. Our data demonstrate that the effect of com...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Konovalova NP,Diatchkovskaya RF,Volkova LM,Kagiya TV

    更新日期:1995-01-01 00:00:00

  • Alpha1,2-fucosyl transferase gene, the key enzyme of Lewis y synthesis, promotes Taxol resistance of ovarian carcinoma through apoptosis-related proteins.

    abstract::We aimed to investigate the role of FUT1 gene in Taxol resistance and to explore its mechanism in epithelial ovarian cancer. Three ovarian cancer cell lines, ES-2, SK-OV-3 and OVCAR-3 were selected from epithelial ovarian cancer in this experiment. Western blot was used to validate the protein expression level of FUT1...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2018_170823N552

    authors: Li FF,Sha D,Qin XY,Li CZ,Lin B

    更新日期:2018-01-01 00:00:00

  • Autologous Hsp70 immunization induces anti-tumor immunity and increases longevity and survival of tumor-bearing mice.

    abstract::Heat Shock proteins 70 (Hsp70) is a family of highly conserved molecules that maintain the function of crucial cellular pathways during stress. Hsp70 derived from tumor cells is bound with tumor antigenic peptides from the diverse antigen cytosolic pool. Tumor-derived Hsp70 preparations after ex vivo administration pe...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2009_03_259

    authors: Kumar S,Deepak P,Acharya A

    更新日期:2009-01-01 00:00:00

  • Humoral and cellular immunity in long-term surviving patients with malignant lymphoma.

    abstract::Humoral and cellular immunity was followed in a group of long-term surviving patients with malignant lymphoma, viz. serum immunoglobulins quantitatively, T lymphocytes by the E rosette and B lymphocytes by the EAC rosette methods. A single examination of this group was compared with data from a control group of normal...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Opat P,Kolár V,Lauerová L,Pintera J,Zemanová D

    更新日期:1980-01-01 00:00:00

  • miR-155-5p increases the sensitivity of liver cancer cells to adriamycin by regulating ATG5-mediated autophagy.

    abstract::Liver cancer is the sixth most prevalent cancer worldwide and the third leading cause of cancer-related deaths. Adriamycin (ADR) resistance, which often leads to the progression of malignant tumors, is a major treatment obstacle for liver cancer. It has been confirmed that miR-155-5p could reverse drug resistance in h...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2020_200106N17

    authors: Yu Q,Xu XP,Yin XM,Peng XQ

    更新日期:2021-01-01 00:00:00

  • Microsomal epoxide hydrolase polymorphisms, cigarette smoking and prostate cancer risk in the Slovak population.

    abstract::Polymorphisms in tobacco carcinogen metabolizing enzymes may generate interindividual variations towards the risk of developing prostate cancer. One of these enzymes is microsomal epoxide hydrolase (EPHX1) which metabolizes polycyclic aromatic hydrocarbons, or PAH, carcinogens found in cigarette smoke. The activity of...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2012_010

    authors: Sivonova MK,Dobrota D,Matakova T,Dusenka R,Grobarcikova S,Habala V,Salagovic J,Tajtakova M,Pidanicova A,Valansky L,Lachvacs L,Kliment J Jr,Nagy V,Kliment J

    更新日期:2012-01-01 00:00:00

  • The release of TNF-alpha (factor) by peritoneal macrophages of hamsters bearing transplantable melanomas.

    abstract::The influence of two kinds of transplantable melanomas on the secretory function of peritoneal macrophages, and particularly the release of TNF-alpha has been studied. The results showed a statistically significant increase of protein content in the supernatants from 24 h cultured macrophages from melanoma-bearing ham...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Kozłowska K,Cichorek M

    更新日期:1995-01-01 00:00:00