Abstract：
:The effect of CMF (cyclophosphamide, methotrexate and 5-fluorouracil) or tamoxifen treatment on endocrine function was investigated in premenopausal and postmenopausal breast cancer patients. CMF therapy resulted in ovarian failure but pituitary and adrenal functions were unaffected in premenopausal patients. Although amenorrhea was achieved within two to five months in older patients, younger patients required large cumulative doses of cytotoxic drugs to exhibit ovarian dysfunction. CMF therapy had no effect on hormonal levels in postmenopausal patients indicating that in this group therapeutic response is not mediated via the endocrine system. On the other hand, tamoxifen therapy in postmenopausal patients resulted in hyperestrogenemia.
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Bhatavdekar JM,Shah NG,Patel DD,Karelia NH,Trivedi SN,Vora HH,Ghosh N,Giri DD,Balar DBsubject
Has Abstractpub_date
1992-01-01 00:00:00pages
123-7issue
2eissn
0028-2685issn
1338-4317journal_volume
39pub_type
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