Endocrine function in premenopausal and postmenopausal advanced breast cancer patients treated with CMF or tamoxifen.

Abstract:

:The effect of CMF (cyclophosphamide, methotrexate and 5-fluorouracil) or tamoxifen treatment on endocrine function was investigated in premenopausal and postmenopausal breast cancer patients. CMF therapy resulted in ovarian failure but pituitary and adrenal functions were unaffected in premenopausal patients. Although amenorrhea was achieved within two to five months in older patients, younger patients required large cumulative doses of cytotoxic drugs to exhibit ovarian dysfunction. CMF therapy had no effect on hormonal levels in postmenopausal patients indicating that in this group therapeutic response is not mediated via the endocrine system. On the other hand, tamoxifen therapy in postmenopausal patients resulted in hyperestrogenemia.

journal_name

Neoplasma

journal_title

Neoplasma

authors

Bhatavdekar JM,Shah NG,Patel DD,Karelia NH,Trivedi SN,Vora HH,Ghosh N,Giri DD,Balar DB

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

123-7

issue

2

eissn

0028-2685

issn

1338-4317

journal_volume

39

pub_type

杂志文章
  • In vitro and in vivo effects of reovirus on HPV16-transformed mice cells.

    abstract:UNLABELLED:Oncolytic viruses are examined to serve as anticancer therapeutics. It is expected that in addition to direct oncolytic effect their action will also help eliciting a solid antitumor immunity. In presented series of experiments we have employed two HPV16-transformed mouse (strain C57/B6) cell lines, TC-1 and...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2010_03_207

    authors: Figova K,Sobotkova E,Duskova M,Ludvikova V,Vonka V,Eckschlager T

    更新日期:2010-01-01 00:00:00

  • IgD paraproteinemias.

    abstract::In a series of 2038 paraproteinemic sera, 9 IgD paraproteins (0.44%) were found. Clinical diagnosis of all the 9 was multiple myeloma. One patient had an IgD-lambda plasmacytoma which developed into plasmocellular leukemia. Our series of IgD paraproteins consisted of 6 females and 3 males with a mean age of 58.5 years...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Tichý M,Matĕja F,Urban P,Matuska M

    更新日期:1993-01-01 00:00:00

  • MiR-129-5p is down-regulated and involved in migration and invasion of gastric cancer cells by targeting interleukin-8.

    abstract::Expression of microRNA-129-5p (miR-129-5p) has been reported to decrease in gastric cancer (GC). However, little information is available about how miR-129-5p affects cell migration and invasion of GC. Cancer samples and matched non-tumor adjacent tissues were obtained from patients with GC. Besides, peripheral blood ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2016_503

    authors: Jiang Z,Wang H,Li Y,Hou Z,Ma N,Chen W,Zong Z,Chen S

    更新日期:2016-01-01 00:00:00

  • Tumoricidal properties of rat peritoneal macrophages activated with various activators depend on nitrogen oxid synthesis.

    abstract::Cytolytic activity of mineral oil elicited rat peritoneal macrophages activated by lipopolysaccharide (LPS) and/or rIFN-gamma, rIL-2, Zymosan and PMA (4-beta-phorbol-12-beta-myristate 13-alpha-acetate) was detected in the presence of various concentrations of L-arginine. This paralleled the NO2- production in the pres...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Kusenda J,Kalafut F,Klobusická M,Novotná L

    更新日期:1992-01-01 00:00:00

  • Prognostic validation of the WHO 2010 grading system in pancreatic insulinoma patients.

    abstract::The purpose of this study was to evaluate the prognostic potential of the World Health Organization (WHO) 2010 grading system in patients with pancreatic insulinomas. This was a retrospective study that analyzed the overall survival of 85 pancreatic insulinoma patients treated at our Institute between May 2002 and Mar...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2015_058

    authors: Wang L,Yang M,Zhang Y,Xu S,Tian BL

    更新日期:2015-01-01 00:00:00

  • Comparative study of DNA-damaging and DNA-protective effects of selected components of essential plant oils in human leukemic cells K562.

    abstract::Eucalyptol, carvacrol and thymol represent components of plant essential oils characterized by a wide range of biological effects toward microorganisms, fungi, insects, etc. However, till now only a few investigations have been carried out to study the effects of essential oils and their components on human cells cult...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Horvathova E,Turcaniova V,Slamenova D

    更新日期:2007-01-01 00:00:00

  • Paclitaxel (Taxol): a review of its antitumor activity in clinical studies Minireview.

    abstract::The paclitaxel represents first agent from novel class of antineoplastic drugs-taxoids. The clinical development of paclitaxel was initially hampered by hypersensitivity reactions. Current dosage regiments with premedication reduced the incidence of these side effects to less than 3%. The major dose-limiting adverse e...

    journal_title:Neoplasma

    pub_type: 杂志文章,评审

    doi:

    authors: Hájek R,Vorlicek J,Slavik M

    更新日期:1996-01-01 00:00:00

  • The impact of positron emission tomography in the radiotherapy treatment planning. Minireview.

    abstract::Positron emission tomography (PET) is a new diagnostic method recently widely used in oncology. It is applied to distinguish benign and malign tumors, to diagnose relaps or posttherapeutic changes. PET is also complementary method to the standard used methods such as CT or NMR. Now it is used even as the predict facto...

    journal_title:Neoplasma

    pub_type: 杂志文章,评审

    doi:

    authors: Dolezelová H,Slampa P

    更新日期:2007-01-01 00:00:00

  • Value of lymphangiography in the diagnosis and treatment of lymphangioma.

    abstract::On the basis of the author's own results and literary data emphasis is laid on the significance of lymphography for confirming or establishing a diagnosis, for determining the extent of a lesion and for proper considerations on indications for surgical treatment. Relymphography following a surgical intervention is cap...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Kutarna A

    更新日期:1975-01-01 00:00:00

  • Some approaches to the perfection of histooncological diagnoses.

    abstract::Inaccuracy, inadequate use of histooncological diagnosis and deficient use of the diagnostic scope have been found in our set of examinations. Responsibility for diagnostic errors resided most frequently in poor knowledge of the problem. Therefore more consistent postgraduate training in histooncological classificatio...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Bednár B

    更新日期:1988-01-01 00:00:00

  • Antitumor effect of 2-thio-4-hydrazinouracil on transplantable tumors.

    abstract::The cytostatic activity of 2-thio-4-hydrazinouracil (THU) on some transplantable tumors has been studied. A strong effect of this compound (between 60% and 100% suppression) has been found in the case of Myeloma P-8 (MOPC-21) and Sarcoma 180 (Crocker). A less pronounced effect has been observed on Yoshida sarcoma, whi...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Golovinsky EV,Emanuilov EA,Spassovska NC,Spassov AV

    更新日期:1975-01-01 00:00:00

  • Alpha1,2-fucosyl transferase gene, the key enzyme of Lewis y synthesis, promotes Taxol resistance of ovarian carcinoma through apoptosis-related proteins.

    abstract::We aimed to investigate the role of FUT1 gene in Taxol resistance and to explore its mechanism in epithelial ovarian cancer. Three ovarian cancer cell lines, ES-2, SK-OV-3 and OVCAR-3 were selected from epithelial ovarian cancer in this experiment. Western blot was used to validate the protein expression level of FUT1...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2018_170823N552

    authors: Li FF,Sha D,Qin XY,Li CZ,Lin B

    更新日期:2018-01-01 00:00:00

  • Analysis of surface and cytoplasmic immunoglobulin light/heavy chains by flow cytometry using a lysed-whole-blood technique: Implications for the differential diagnosis of B-cell malignancies.

    abstract::The study was aimed at the proper detection of surface and cytoplasmic clonal Ig light/heavy chains in the frame of multiparameter flow cytometry analysis of some B-cell malignancies. An exact direct evidence has been obtained that the leukemia cells following staining by antibodies to immunoglobulins will need to be ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Babusíková O,Stevulová L

    更新日期:2004-01-01 00:00:00

  • Realization of genetic information programming the synthesis of pepsinogen-pepsin in the mucous membrane and tumors of the stomach in man.

    abstract::Up to 19--20 fractions of separate RNA species and groups have been revealed in malignant tumors of the stomach and mucous membrane of patients with stomach cancer, ulcer and polyposis of the stomach by means of the method of analytical and preparative electrophoresis in 2.5% polyacrylamide gel. A more intensive incor...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Seitz JF,Kalinvosky VP

    更新日期:1976-01-01 00:00:00

  • Phorbol ester-induced modulation of cell surface antigens on U-937 cells in protein-free medium: effect of protein kinase and calmodulin inhibitors.

    abstract::Phorbol ester (PMA) induced decrease in cell surface expression of CD4 antigen was potentiated on human monoblastoid cell line U-937 cultured and induced in protein-free culture medium. Down-regulation of the CD4 antigen was partially inhibited by the isoquinoline protein kinase inhibitor H7 and unaffected by the calm...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Hunáková L,Sedlák J,Chorváth B

    更新日期:1993-01-01 00:00:00

  • USF1 gene polymorphisms may associate with the efficacy and safety of chemotherapy based on paclitaxel and prognosis in the treatment of ovarian cancer.

    abstract::This study was supposed to investigate the correlation between the functional single nucleotide polymorphisms (SNPs) (rs2516839 and rs3737787) in USF1 gene and the efficacy and safety of paclitaxel-based chemotherapy and prognosis in the treatment of ovarian cancer (OC). In total 100 OC patients were selected and divi...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2018_170322N205

    authors: Ye H,Liu XJ,Hui Y,Liang YH,Li CH,Wan Q

    更新日期:2018-01-01 00:00:00

  • Prevalent expression of MHC class I chain-related molecule A in human osteosarcoma.

    abstract::MHC class I chain-related molecule A (MICA) is one of the major ligands for activating immune-receptor NKG2D which is expressed on NK cells and cytotoxic T lymphocytes. The release and sustained expression of MICA protein can impair NKG2D-mediated cytotoxic activity by reducing NKG2D receptor on immune effector cells....

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Lu SM,Xiao P,Xue L,Che LH,Yang P,Li Y,Qiao H

    更新日期:2008-01-01 00:00:00

  • The radiosensitivity of human malignant melanomas evaluated by cytokinesis-block micronucleus assay.

    abstract::Cytokinesis-block micronucleus assay (CB-MNA) was applied for comparison of radiation sensitivity of 25 human malignant melanomas in primary culture. Cells obtained from tumor specimens were irradiated (0-4.Gy) on dishes, incubated with cytochalasin B (2 micrograms/ml) to block cytokinesis, stained in situ and micronu...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Wideł M,Dobrut M,Maka B,Lubecka B,Pluciennik A

    更新日期:1997-01-01 00:00:00

  • Sonography in the diagnosis and therapy monitoring of lymphomas.

    abstract::Multiple ultrasonographic (USG) evaluations of abdomen were performed in 97 patients: 30 with Hodgkin's disease (HD), 60 with non-Hodgkin lymphomas (NHL) and 7 with primary gastric lymphoma (PGL) before or during chemo- or X-ray therapy. In 33% of HD patients USG was normal, while in 63% splenomegaly, in 40% hepatomeg...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Wojnar J,Kalina Z,Stella-Hołowiecka B,Krawczyk-Kuliś M,Wróbel R,Hołowiecki J

    更新日期:1992-01-01 00:00:00

  • Puerarin alleviates the progression of non-small cell lung cancer by regulating the miR-342/CCND1 axis.

    abstract::Puerarin has recently been demonstrated to play anti-cancer roles in a series of human cancers, including non-small cell lung cancer (NSCLC), possibly through regulation of cancer-related microRNAs (miRNAs). The purpose of the present study was to further investigate the detailed role and underlying mechanism of puera...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2020_191107N1145

    authors: Huang SR,Jin SS,Xu B,Wang RP

    更新日期:2020-11-01 00:00:00

  • Significance of CEA, AFP, SP1 and HCG as tumor markers in ovarian carcinoma.

    abstract::The significance of CEA, AFP, HCG and SP1 determinations in 85 patients with ovarian cancer were analyzed from the point of view of evaluation of the clinical status of the patients. On the basis of the trials it was stated that a satisfactory correlation between the extension of the tumor and the serum CEA level was ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Pulay T,Csömör S,Mészáros K,Szarka G,Csabay L,Szinnyai A

    更新日期:1987-01-01 00:00:00

  • A pilot study testing the genetic polymorphism of N-acetyltransferase 2 as a risk factor in lung cancer.

    abstract::NAT2 as phase II enzyme is involved in the detoxification/activation of various drugs, environmental substances and carcinogenic compounds. A genotyping approach has been used to investigate NAT2 genotype with putative relevance in lung cancer in population of 110 Slovak-Caucasians patients and 167 non-malignant indiv...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Habalová V,Salagovic J,Kalina I,Stubna J

    更新日期:2005-01-01 00:00:00

  • Estimation of oncostatin M (OSM) secretion by peritoneal macrophages with regard to the progression of transplantable melanomas.

    abstract::The authors have studied the influence of two kinds of transplantable melanomas on the secretion of oncostatin M (OSM) and total proteins by peritoneal macrophages. Culture supernatant samples were tested by ELISA. The macrophages of melanoma-bearing animals released a lower amount of OSM than those of the controls. A...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Kozłowska K,Cichorek M,Zarzeczna M

    更新日期:1998-01-01 00:00:00

  • Quadruple cancer, including triple cancers in the head and neck region.

    abstract::Multiple primary tumors are not rare: they are encountered in 3-5% of malignant tumors. They are particularly frequent in the head and neck [20]. They are most often met with secondary malignant tumors; triple tumors occur in only 0.5%, quadruple tumors in 0.3% of malignant tumors. The possibility of developing a seco...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Németh Z,Czigner J,Iván L,Ujpál M,Barabás J,Szabó G

    更新日期:2002-01-01 00:00:00

  • Prognostic significance of morphological assessment of plasma cells in multiple myeloma.

    abstract::Multiple myeloma (MM) is a hematological malignancy caused by clonal proliferation of malignant plasma cells (PC). The aim of the work is to determine prognostic significance of morphological subtypes of PC in relation to overall treatment response, long-term survival and other conventional prognostic parameters. One ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2011_06_554

    authors: Al-Sahmani M,Trnavska I,Sevcikova S,Antosova M,Antosova L,Kissova J,Adam Z,Pour L,Nemec P,Greslikova H,Krejci M,Zahradova L,Bulikova A,Penka M,Hajek R

    更新日期:2011-01-01 00:00:00

  • Sentinel node biopsy in breast cancer: short time results show appropriate regional control.

    abstract::Sentinel node biopsy becomes a standard diagnostic and therapeutic tool in breast cancer in certain indications, while in other indications its validity is still reviewed. The authors present their experience with this method. In the years 2000-2006 700 patients underwent surgery. 704 sentinel node biopsies were perfo...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Fait V,Chrenko V

    更新日期:2007-01-01 00:00:00

  • Sensitivity of TSTA and species-specific cell membrane antigens of tumor cells to glutaraldehyde treatment.

    abstract::In vivo immunogenicity and in vitro species-specific membrane antigens in tumor cells treated or untreated with glutaraldehyde (GA) were studied. Two different syngeneic Syrian hamster transplantable tumor cell lines (spontaneous liver cancer and SV40-induced sarcoma) not only lost immunogenicity after GA treatment bu...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Kluchareva TE,Matveeva VA,Deichman GI

    更新日期:1978-01-01 00:00:00

  • Potential carcinogenic and inhibitory activity of compounds isolated from Lilium candidum L.

    abstract::This paper deals with determination of potential carcinogenic and inhibitory activity of 10 compounds isolated from the ethanolic extract of Lilium candidum L. perfonned by DC polarography. The series of investigated compounds consisted of two spirostanol saponins, two pyroline derivatives, jatropham and its glucoside...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Vachálková A,Eisenreichová E,Haladová M,Mucaji P,Józová B,Novotný L

    更新日期:2000-01-01 00:00:00

  • Gpnmb/osteoactivin, an attractive target in cancer immunotherapy.

    abstract::Cancer is a complex disease with interactions between normal and neoplastic cells. Since current therapies for cancer largely rely on drugs or radiation that kill dividing cells or block cell division, these treatments may have severe side effects on normal proliferating cells in patients with cancer. Recently, immuno...

    journal_title:Neoplasma

    pub_type: 杂志文章,评审

    doi:10.4149/neo_2012_001

    authors: Zhou LT,Liu FY,Li Y,Peng YM,Liu YH,Li J

    更新日期:2012-01-01 00:00:00

  • The miR-93 promotes proliferation by directly targeting PDCD4 in hepatocellular carcinoma.

    abstract::Hepatocellular carcinoma (HCC) is the second leading cause of cancer mortality worldwide. Although advances have made in treatment of HCC, the overall survival rate remains low and the molecular pathogenesis of HCC is still poorly understood. The purpose of this study was to explore the molecular pathogenesis of HCC. ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2017_516

    authors: Huang H,Wang X,Wang C,Zhuo L,Luo S,Han S

    更新日期:2017-01-01 00:00:00