Inhibition of colony-forming cells from bone marrow of leukemic patients by 3-oxauracil.

Abstract:

:An in vitro system of colony forming cell inhibition was used for evaluation of 3-oxauracil (2,3-dihydro-1,3-6H-oxazine-2,6-dione) effectivity against bone marrow cells from 18 leukemic patients. The highest inhibitive activity of the 3-oxauracil was found in cases of acute lymphoblastic leukemia, comparing with bone marrow cells from patients with acute myeloblastic and chronic myeloid leukemia. According to the morphological characteristics of the formed colonies, lymphoblastic leukemia cells could be discerned from the myeloblastic ones in this system.

journal_name

Neoplasma

journal_title

Neoplasma

authors

Reiner P,Mardiak J,Reinerová M,Ujházy V

subject

Has Abstract

pub_date

1981-01-01 00:00:00

pages

533-9

issue

5

eissn

0028-2685

issn

1338-4317

journal_volume

28

pub_type

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