解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Health care costs are continuously increasing. Multiple myeloma represents approximately 1% of all malignancies and the 5-year prevalence is 230,000 patients on average. In addition, there is an annual incidence of 3.8/100,000 in Slovakia. In total economic burden assessment, it is important to focus not only on direc...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2021_201103N1173
更新日期:2021-01-28 00:00:00
abstract::Bladder cancer (BCa) is a common carcinoma of the urinary tract which occurs in the bladder mucosa. In recent years, people have recognized that epigenetic changes such as DNA methylation play important roles in the development of BCa, but the specific mechanism is unclear. In this study we detected the methylation ra...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2020_200928N1035
更新日期:2021-01-14 00:00:00
abstract::Liver cancer is the sixth most prevalent cancer worldwide and the third leading cause of cancer-related deaths. Adriamycin (ADR) resistance, which often leads to the progression of malignant tumors, is a major treatment obstacle for liver cancer. It has been confirmed that miR-155-5p could reverse drug resistance in h...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2020_200106N17
更新日期:2021-01-01 00:00:00
abstract::It is generally believed that the existence of cancer stem cells (CSCs) is related to tumor recurrence and metastasis of hepatocellular carcinoma (HCC). Neuropilin1 (NRP1) is involved in numerous pathophysiological processes of tumor progression, however, whether NRP1 is involved in the regulation of liver CSCs and me...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2020_200914N982
更新日期:2020-12-23 00:00:00
abstract::Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, and it carries a poor prognosis. Clarifying the pathologic mechanisms of this disease will be beneficial for the diagnosis and treatment of HCC. LncRNA MEG8 is involved in several tumors but its role in HCC progression remains unknown. This st...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2020_200730N785
更新日期:2020-11-05 00:00:00
abstract::Although the candidemia still remains a serious health problem, the study of candidemia in cancer patients is limited. We conducted a retrospective analysis of candidemia among 31 adult patients hospitalized in one oncological center. The mean annual incidence of candidemia was 0.14±0.05/1000 patient-days (range 0.04-...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2020_200204N105
更新日期:2020-11-01 00:00:00
abstract::Puerarin has recently been demonstrated to play anti-cancer roles in a series of human cancers, including non-small cell lung cancer (NSCLC), possibly through regulation of cancer-related microRNAs (miRNAs). The purpose of the present study was to further investigate the detailed role and underlying mechanism of puera...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2020_191107N1145
更新日期:2020-11-01 00:00:00
abstract::Osteosarcoma (OS) is a common malignant bone tumor that occurs in adolescents or children under the age of 20, which is extremely difficult to cure and has a high recurrence rate. Recent studies showed that cell division cycle 20 (CDC20) overexpression is associated with poor prognosis in patients with osteosarcoma. H...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2020_200614N629
更新日期:2020-10-30 00:00:00
abstract::The analysis of DNA methylation patterns in circulating cell-free DNA in body fluids is an analyte of great interest in clinical research. Downstream of Kinase (DOK) proteins represent a multigenic family of adaptors that includes negative regulators of immune cell signaling and plays important roles in signaling, cel...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2020_190811N747
更新日期:2020-07-01 00:00:00
abstract::CD73 is a membrane-bound enzyme that catalyzes the extracellular conversion of adenosine monophosphate to adenosine. Adenosine is thought to play a role in promoting tumor growth and survival together with suppressing the host immune responses, which contribute to the multistep process of tumorigenesis. Here, we studi...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2020_190826N822
更新日期:2020-07-01 00:00:00
abstract::Genetic testing based on next-generation sequencing (NGS) analysis has recently been used to diagnose hereditary diseases. In this study, we explored the usefulness of our custom amplicon panel that targeted 23 genes related to hereditary tumors given in the American College of Medical Genetics and Genomics recommenda...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2020_190918N925
更新日期:2020-07-01 00:00:00
abstract::Human immediate early response 2 (IER2) has been implicated in tumor cell motility and metastasis; however, the underlying mechanisms in hepatocellular carcinoma (HCC) metastasis remain to be clarified. In this study, we demonstrate that dysregulation of IER2 was shown in HCC clinical samples, and IER2 expression resu...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2020_190818N781
更新日期:2020-05-01 00:00:00
abstract::Mammalian target of rapamycin (mTOR) has two subtypes, i.e., mTORC1 and mTORC2, which contain the Raptor and Rictor core molecules, respectively. The effect of Raptor and Rictor on hypoxia inducible factor (HIF)-1α, HIF-2α, and vascular endothelial growth factor (VEGF) in colorectal cancer (CRC) is unclear. In this wo...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2020_190705N597
更新日期:2020-05-01 00:00:00
abstract::Lung cancer is a common malignant disease in humans. Both the incidence rate and death rate keep growing in recent years and the prognosis of lung cancer patients is disappointing. Melanoma inhibitory activity (MIA) is a secreted protein and a serum marker for metastasis of melanoma. MIA was reported as an oncogene in...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2020_190511N422
更新日期:2020-05-01 00:00:00
abstract::Oral cancer is one of the common cancers worldwide, among which over 90% are oral squamous cell carcinomas (OSCC). MicroRNAs act as critical regulators of cancer development and progression. MiR-103a-3p has been reported to be upregulated in OSCC patients and closely correlated to poor prognosis, yet its roles in the ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2020_190430N382
更新日期:2020-05-01 00:00:00
abstract::Extranodal NK/T-cell lymphoma nasal type (ENKTL) is a subtype of T cell lymphoma with poor prognosis. In this study, we designed a new prognostic model specifically for ENKTL to improve the risk stratification. In 29 ENKTL patients, we screened mutations in 9 ENKTL-associated genes using next-generation sequencing (NG...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2020_190307N194
更新日期:2020-05-01 00:00:00
abstract::Considering the potency of circRNAs in manifesting neoplastic progression, we attempted to explore the feasibility of applying ciRS-7 for diagnosis and prognosis estimation of cervical cancer (CC). Here 352 CC patients, 204 cervical intraepithelial neoplasia (CIN) patients and 227 healthy controls were recruited. The ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2019_190415N334
更新日期:2020-03-01 00:00:00
abstract::Increasing evidences have proved that circular RNAs (circRNAs), identified as a specific kind of non-coding RNAs, play a potential critical role in tumorigenesis including prostate cancer. However, the function of circRNAs in human prostate cancer remain largely unknown. In this study, we demonstrated that the express...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2019_190213N116
更新日期:2020-01-01 00:00:00
abstract::Ovarian cancer is the most lethal gynecologic malignancy in women with an increasing number of cases worldwide. Chemoresistance is the main obstacle for ovarian cancer treatment during clinical therapy. Previous studies found that programmed cell death 1 ligand 1 (PD-L1) was associated with chemoresistance of cancer. ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2019_190202N106
更新日期:2020-01-01 00:00:00
abstract::Colorectal cancer is one of the deadliest cancers worldwide. Effective screening, surveillance and prevention can decrease its incidence, mortality and burden. This meta-analysis aims to provide a pooled estimation of 5-year survival rate for colorectal cancer based on topography codes and treatment in Iranian populat...
journal_title:Neoplasma
pub_type: 杂志文章,meta分析
doi:10.4149/neo_2019_190131N92
更新日期:2019-11-01 00:00:00
abstract::Prognostic nutritional index (PNI) is a parameter reflecting prognosis for various cancers, including resected lung cancer. However, there were few reports to study the relationship between the PNI and overall survival (OS) in patients with advanced (stage IIIB/IV) non-small lung cancer (NSCLC). In this study, we coll...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2019_190125N76
更新日期:2019-11-01 00:00:00
abstract::This study is intended to investigate the role of Tripartite Motif (TRIM) 31 in glioma. Immunohistochemistry and western blot analysis showed that TRIM31 was overexpressed in high-grade glioma tissues. Univariate survival analysis indicated that high expression of TRIM31 was related to short survival time of glioma pa...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2019_190106N21
更新日期:2019-09-01 00:00:00
abstract::Idiopathic granulomatous mastitis (IGM) is a rare inflammatory breast disease mimicking carcinoma and puerperal or non-puerperal mastitis. The primary purpose of this prospectively performed case control study was to compare clinical and imaging signs of IGM with the reference group of nonspecific, non- puerperal mast...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2019_190201N100
更新日期:2019-07-23 00:00:00
abstract::Peroxisome proliferator activated receptor delta (PPARD) is a nuclear receptor transcription factor whose single nucleotide polymorphism (SNP), especially PPARD-87 T>C (rs2016520), may play an important role in expression regulation of PPARD. But its expression patterns as well as contribution in colorectal cancer (CR...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2018_181012N763
更新日期:2019-07-23 00:00:00
abstract::Laryngeal carcinoma is the second commonest head and neck carcinoma globally. MicroRNA-101 (miR-101) has been reported as a tumor suppressor in multiple malignancies including laryngeal squamous cell carcinoma (LSCC). However, the roles and molecular mechanisms of miR-101 in the development of LSCC have not been fully...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2018_180811N611
更新日期:2019-07-23 00:00:00
abstract::The aim of our study was to correlate the serum concentration of human epididymis protein 4 (HE4) in lung cancer patients with the bone metastases detected by whole-body bone scintigraphy. The serum concentrations of HE4 were determined by electrochemiluminescence immunoassay method in 60 patients with lung cancer and...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2018_181212N961
更新日期:2019-06-29 00:00:00
abstract::The treatment of locally advanced head and neck cancer (LAHNC) requires a multimodality approach. Radiotherapy with combination of chemotherapy are demonstrated to be effective, however, the treatment intensification leads to increased toxicity at the same time. The implementation of three-dimensional conformal radiot...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2018_181209N941
更新日期:2019-06-19 00:00:00
abstract::Bladder cancer remains a very challenging disease to treat with the high rates of recurrence and progression associated with current therapies. Although the association between bladder cancer pathology and circRNAs remains undetermined, circRNAs signatures may be useful as prognostic and predictive factors and clinica...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2019_190107N25
更新日期:2019-06-03 00:00:00
abstract::Melanoma is a malignant tumor. The acquisition of stemness of melanoma cells aggravates the malignant transformation, which can be regulated by microRNAs (miRNAs, miR). MiR-363-3p is a key tumor-related miRNA, but its role in stemness and melanoma cells is still unknown. Presently, miR-363-3p, induced by hypoxia induc...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2018_180828N655
更新日期:2019-05-23 00:00:00
abstract::Hepatocellular carcinoma is the most common primary malignancy of the liver. The chemotherapeutic drug cisplatin is widely used for advanced liver cancer. However, the development of cisplatin resistance in cancer cells, which is related with the decreased cellular susceptibility to apoptosis, results in a major limit...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:2019-05-11 00:00:00
abstract::The aim is to present the technical feasibility and efficacy of multiple re-irradiation (re-EBRT) for local recurrence of prostate cancer (PCa) using retrospective analysis of an updated series of patients who received ablative re-EBRT with stereotactic image-guided technique for isolated local recurrence of PCa. Eigh...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2018_180723N520
更新日期:2019-03-05 00:00:00
abstract::Long non-coding RNAs (lncRNAs) are strongly associated with cancer biology. The objective of this study is to investigate the expression profile of lncRNAs in human papillary thyroid carcinoma (PTC), and to understand the biological role of lncRNAs and their involvement in PTC oncogenesis. The lncRNAs and messenger RN...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2018_180625N414
更新日期:2019-03-05 00:00:00
abstract::The development of distant metastases is the final stage in the progression of solid cancer and is responsible for the majority of cancer-related deaths. Epithelial-mesenchymal transition (EMT) is involved in cancer progression and metastasis. In the present study we used different types of intracellular bacteria isol...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2018_181120N874
更新日期:2019-02-06 00:00:00
abstract::GRK5 is a multifunctional protein that is able to move within the cell in response to various stimuli to regulate key intracellular signaling from receptor activation, on plasmamembrane, to gene transcription, in the nucleus. Thus, GRK5 is involved in the development and progression of several pathological conditions ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2018_180621N409
更新日期:2019-02-06 00:00:00
abstract::Oxaliplatin is commonly used in managing malignancy, including colorectal cancer. While treatment often fails due to decreased drug sensitivity, the mechanisms involved are not clear. In this study, we investigate how exosomal miR-19b participates in oxaliplatin sensitivity and then prove that miR-19b down-regulates o...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2018_180306N155
更新日期:2019-01-15 00:00:00
abstract::Pyruvate dehydrogenase kinase 1 (PDHK1) and carbonic anhydrase IX (CAIX) are some of the most hypoxia-inducible proteins associated with tumors, implicated in glucose metabolism and pH regulation, respectively. They both appear to be necessary for model tumor growth, and their high level of expression in human tumors ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2018_180531N357
更新日期:2018-12-10 00:00:00
abstract::In contrast to other countries with predominantly white populations, Russian smoking-related lung cancers (LC) are mainly squamous cell carcinomas and approximately half lung adenocarcinomas (AdCa) are not related to tobacco consumption. Given that smoking significantly influences the probability of presence of action...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2018_171225N843
更新日期:2018-11-15 00:00:00
abstract::In comparison with the 7th Edition, the 8th Edition of the American Joint Committee on Cancer (AJCC) staging system no longer considers the mitotic count in the a or b T1 categorization for melanoma, but it adopts a sub-stratification based on the Breslow's depth. Today, the death burden of thin melanoma is still seve...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2018_170701N452
更新日期:2018-09-19 00:00:00
abstract::The mannose 6-phosphate/insulin-like growth factor 2 receptor (CD222, M6P/IGF2R) is a multifunctional transmembrane type I receptor, mostly localized intracellularly, less on the surface of all types of mammalian cells. It is known both to transport lysosomal enzymes through their mannose 6-phosphate moieties and to i...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2018_171203N792
更新日期:2018-09-19 00:00:00
abstract::Glioma is among the most fatal brain tumors characterized by a highly malignancy and rapid progression and early metastasis. Dysregulation of long non-coding RNA differentiation antagonizing non-protein coding RNA (LncRNA DANCR) is associated with the development, progression and metastasis of various cancers. In the ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2018_170724N498
更新日期:2018-09-19 00:00:00