Abstract:
:Research indicates that after EGFR-tyrosine kinase inhibitors (EGFR-TKIs) treatment of non-small cell lung cancer (NSCLC), patient immune function significantly improved, and that circulating tumor cells (CTCs) measurements and peripheral blood epidermal growth factor receptor (EGFR) mutation data can guide TKIs treatment. Sixty-six advanced NSCLC patients treated with TKIs were enrolled and CTCs, EGFR expression, T cell subsets and natural killer (NK) cells in peripheral blood were measured using flow cytometry before and after treatment and assessed with respect to patient prognosis. CTCs and EGFR expression were negatively correlated with cellular immune function and immune recovery after EGFR-TKI treatment. Thus, CD4+/ CD8+ ratios and NK cells may be useful prognostic indicators for advanced NSCLC patients who receive TKIs treatment.
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Tu C,Zhu Y,Jiang B,He W,Jin Cdoi
10.4149/neo_2017_418subject
Has Abstractpub_date
2017-01-01 00:00:00pages
619-625issue
4eissn
0028-2685issn
1338-4317journal_volume
64pub_type
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