Immunological response of patients with tumors of the urogenital tract: a follow-up of cell-mediated antitumor immunity by the LAI test.

Abstract:

:Antigen-induced inhibition of leukocyte adherence is a suitable method providing information on immunological response of the tumor bearers. Leukocytes from patients' blood were tested by an in vitro method to detect cell-mediated antitumor immunity. Positive reactions of leukocytes to the specific antigen were found in carcinoma of the uterine cervix, vulva and ovary in 13 patients. The modified LAI test evaluated on the basis of free cells in Eagle's medium using the specific antigen is a simplified reversed method which, however, keeps the specificity.

journal_name

Neoplasma

journal_title

Neoplasma

authors

Holán V,Heyberger K,Bubeník J,Hasek M,Kanka J,Laurová L

subject

Has Abstract

pub_date

1977-01-01 00:00:00

pages

71-9

issue

1

eissn

0028-2685

issn

1338-4317

journal_volume

24

pub_type

杂志文章
  • Multiparametric MRI analysis of morphologico-functional features of DCIS - correlation with grade of nuclear atypia.

    abstract::The aim was to analyze morphologico-functional characteristics of ductal carcinoma in situ (DCIS) in breast MRI to assess signs correlating with the degree of nuclear atypia. From 636 malignant lesions, 114 were DCIS (17.92%): 44 cases of high-grade (38.60%), 37 intermediate (32.45%), 33 low-grade (28.95%). MRI charac...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2018_170509N333

    authors: Lehotska V,Rauova K,Vanovcanova L

    更新日期:2018-03-14 00:00:00

  • Lowering of the tumoricide activity of human serum with Varidase. II. Antibodies against Varidase in human serum measured by complement binding.

    abstract::Active human serum manifests a tumoricide effect against cells of the Ehrlich ascites tumor. Sera of patients with Ca ventriculi show a higher effect than those of patients with a chronic streptococcal disorder, in comparison with intact subjects. This tumorcide effect is depressed by Varidase, the degree of depressio...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Mikolásek J

    更新日期:1975-01-01 00:00:00

  • Protection from pan masala induced genomic damage by beta-carotene and retinoic acid--an in vitro experience.

    abstract::Cytogenetic studies in Chinese hamster ovary (CHO) cells using aqueous and organic extracts of pan masalas, as well as genomic damage observed among pan masala consumers have conclusively shown genotoxic potential of pan masala-a dry complex mixture of areca nut, lime, catechu, cardamom, unspecified flavoring agent, e...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Patel RK,Trivedi AH,Jaju RJ,Kukreti MS,Bhatavdekar JM,Shah PM,Patel DD

    更新日期:1998-01-01 00:00:00

  • The role of radiation therapy in the treatment of cancer of the prostate.

    abstract::The review of the literature assessing the value of external radiotherapy in treatment of patients with prostatic cancer is presented. Radiotherapy appears to be the curative treatment since about 55% of 10 years symptoms free survival rate can be achieved in stages A and B and 35% in stage C. The results of radiother...

    journal_title:Neoplasma

    pub_type: 杂志文章,评审

    doi:

    authors: Korzeniowski S

    更新日期:1988-01-01 00:00:00

  • Irradiation scheme using three daily fractions in the radiation therapy of pharyngeal and oral carcinomas.

    abstract::A group of 34 patients were treated by irradiation using 3 daily fractions of 1 Gy each at 4 h intervals. The overall TD in all of the patients was 60 Gy administered within 26 days. The irradiation was carried out by telecurietherapy utilizing 60Co. Twenty-eight patients had the tumor in the oropharynx, 1 in the hypo...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Durkovský J,Jancina J,Siracká E,Krajci M

    更新日期:1984-01-01 00:00:00

  • Retrospective analysis of efficacy of trastuzumab in adjuvant treatment of HER 2 positive early breast cancer - single institution experience.

    abstract::Addition of trastuzumab to chemotherapy is the cornerstone of adjuvant treatment of early HER2 positive breast cancer. Clinical trials and metaanalyses of adjuvant trastuzumab have shown significant reduction in risk of recurrence and death. Nevertheless, the real magnitude of the effect of any drug must be reevaluate...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2016_513

    authors: Ban M,Viculin J,Tomic S,Capkun V,Strikic A,Mise BP,Utrobicic I,Vrdoljak E

    更新日期:2016-01-01 00:00:00

  • The potential roles of vesicle-enclosed miRNAs in communication between macrophages and cancer cells in tumor microenvironment.

    abstract::Functional microRNA (miRNA) molecules are transported in extracellular vesicles among tumor cells and cells of the immune system. Macrophages as integral components of tumor microenvironment are known as potential contributors to tumor growth and progression. We searched for studies which could provide a direct link b...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2017_311

    authors: Korabecna M,Koutova L,Tesarova P

    更新日期:2017-01-01 00:00:00

  • Second line treatment in advanced non-small cell lung cancer (NSCLC): comparison of efficacy of erlotinib and chemotherapy.

    abstract::Molecular targeted therapy based on tyrosine kinase inhibitors, directed at the epidermal growth factor receptor (EGFR) is one of novel options for management of NSCLC. Erlotinib is EGFR tyrosine kinase inhibitor used for treatment of the advanced NSCLC. This presented study is focused on comparison of erlotinib and c...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2013_017

    authors: Fiala O,Pesek M,Finek J,Krejci J,Bortlicek Z,Benesova L,Minarik M

    更新日期:2013-01-01 00:00:00

  • Potential carcinogenicity of the synthetic 1,3,6-triazine (6-azapyrimidine) nucleic acid analogues determined by DC polarography. II. Nucleosides of 6-azauracil.

    abstract::The polarographic reduction of six synthetic 1,3,6-triazine (6-aza) nucleosides with 6-azauracil as the nucleoside base in the strictly anhydrous solutions was studied in the absence and presence of alpha-lipoic acid. The values of the half-wave potentials E1/2 and the parameter of potential carcinogenicity tg alpha w...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Novotný L,Vachálková A,Pískala A

    更新日期:1999-01-01 00:00:00

  • Significance of P-glycoprotein expression in childhood malignant tumors.

    abstract::Resistance to chemotherapy significantly affects the treatment results in various cancers. Multidrug resistance caused by P-glycoprotein expression is now widely studied in human malignancies. We present the results of P-glycoprotein expression examination in 91 tumor tissue samples obtained from children treated for ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Kucerová H,Sumerauer D,Drahokoupilová E,Pisková M,Bedrnícek J,Eckschlager T

    更新日期:2001-01-01 00:00:00

  • FAB classification of chronic myelomonocytic leukemia: heterogeneity revealed on the basis of bone marrow findings.

    abstract::We report on 12 patients who fulfilled the FAB diagnosis criteria of chronic myelomonocytic leukemia (CMML). Some clinical findings (splenomegaly) as well as biological parameters (WBC count, cellularity of bone marrow sections, presence of dyserythropoiesis in bone marrow smears) were subjected to particular analysis...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Yavòrkovsky LL,Solovei DY,Ryauzova LY,Schvidel LM,Zile MA,Sused SG,Teilane IY

    更新日期:1988-01-01 00:00:00

  • Anal cancer chemoirradiation with curative intent - a single institution experience.

    abstract:UNLABELLED:Results of radiochemotherapy in 50 patients with squamous cell carcinoma of the anal canal, treated with radical radiochemotherapy between January 2003 and September 2007, at the Institute of Oncology Ljubljana are presented. The treatment schedule consisted of 3-D conformal external beam radiotherapy (45 Gy...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2009_02_150

    authors: Oblak I,Petric P,Anderluh F,Velenik V,Hudej R,Fras AP

    更新日期:2009-01-01 00:00:00

  • Growth characteristics of the RL-67 lung tumor -- a new model for experimental therapy of metastatic processes.

    abstract::Implantation of the RL-67 tumor in to the limb muscle of C57Bl strain mice resulted in the tumor growth at the site of implantation and the metastatic process became manifest predominantly in the lungs of all animals. A direct correlation was established between the primary tumor and its metastases. The number of meta...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Karaivanova M,Getov H

    更新日期:1978-01-01 00:00:00

  • Realization of genetic information programming the synthesis of pepsinogen-pepsin in the mucous membrane and tumors of the stomach in man.

    abstract::Up to 19--20 fractions of separate RNA species and groups have been revealed in malignant tumors of the stomach and mucous membrane of patients with stomach cancer, ulcer and polyposis of the stomach by means of the method of analytical and preparative electrophoresis in 2.5% polyacrylamide gel. A more intensive incor...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Seitz JF,Kalinvosky VP

    更新日期:1976-01-01 00:00:00

  • Cigarette smoking extract causes hypermethylation and inactivation of WWOX gene in T-24 human bladder cancer cells.

    abstract::Genomic, epigenetic and expression alterations of WW domain containing oxidoreductase (WWOX) have been implicated in multiple tumor types. The current study was designed to examine the expression of WWOX in tumor tissues of human bladder transitional cell carcinoma (BTCC) and the influence of cigarette smoke extract (...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2012_028

    authors: Yang W,Cui S,Ma J,Lu Q,Kong C,Liu T,Sun Z

    更新日期:2012-01-01 00:00:00

  • Prognostic significance of plasma cell propidium iodide and annexin-V indices and their mutual ratio in multiple myeloma.

    abstract::The aim of this study was a contemporaneous measurement of plasma cells proliferative and apoptotic activity in patients examined at the time of multiple myeloma (MM) diagnosis before initiation of chemotherapy, focussed on the following aspects: determination of prognostic significance of plasma cell propidium iodide...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Scudla V,Ordeltova M,Minarik J,Dusek L,Zemanova M,Bacovsky J

    更新日期:2006-01-01 00:00:00

  • Tumoricidal properties of rat peritoneal macrophages activated with various activators depend on nitrogen oxid synthesis.

    abstract::Cytolytic activity of mineral oil elicited rat peritoneal macrophages activated by lipopolysaccharide (LPS) and/or rIFN-gamma, rIL-2, Zymosan and PMA (4-beta-phorbol-12-beta-myristate 13-alpha-acetate) was detected in the presence of various concentrations of L-arginine. This paralleled the NO2- production in the pres...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Kusenda J,Kalafut F,Klobusická M,Novotná L

    更新日期:1992-01-01 00:00:00

  • Dental pulp mesenchymal stem/stromal cells labeled with iron sucrose release exosomes and cells applied intra-nasally migrate to intracerebral glioblastoma.

    abstract::We report on a simple iron oxide (Venofer) labeling procedure of dental pulp mesenchymal stem cells (DP-MSCs) and DP-MSCs transduced with yeast cytosinedeaminase::uracilphosphoribosyltransferase (yCD::UPRT-DP-MSCs). Venofer is a drug approved for intravenous application to treat iron deficiency anemia in patients. Ven...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2016_611

    authors: Altanerova U,Benejova K,Altanerova V,Tyciakova S,Rychly B,Szomolanyi P,Ciampor F,Cihova M,Repiska V,Ondicova K,Mravec B,Altaner C

    更新日期:2016-01-01 00:00:00

  • The FBXW7 tumor suppressor inhibits breast cancer proliferation and promotes apoptosis by targeting MTDH for degradation.

    abstract::Metadherin (MTDH) is an oncoprotein and is expressed at high levels in a wide variety of human carcinomas, which represents an important genetic determinant and regulates multiple events in tumorigenesis. MTDH promotes breast cancer cell proliferation and tumorigenesis through the activation of numerous signaling path...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2018_170228N149

    authors: Chen X,Li XY,Long M,Wang X,Gao ZW,Cui Y,Ren J,Zhang Z,Liu C,Dong K,Zhang H

    更新日期:2018-01-01 00:00:00

  • GROα expression and its prognostic implications in laryngeal squamous cell carcinoma.

    abstract:UNLABELLED:The growth-regulated oncogene α (GROα) , which is also designated as CXC chemokine ligand 1 (CXCL1), was first identified as an autocrine growth factor in human malignant melanoma. It is involved in tumor development and invasion, and is highly expressed in various human cancers. However, little is known abo...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2015_020

    authors: Han L,Liu W,Chen Y,Wu H,Zhang Y,Jiang B

    更新日期:2015-01-01 00:00:00

  • Acute phase reactants and clinical stages in multiple myeloma.

    abstract::Serum levels of seven specific proteins mostly acute phase reactants (APR) have been studied (transferrin, alpha 2-macroglobulin, alpha 1-antitrypsin, haptoglobin, C3, ceruloplasmin, orosomucoid) in 14 healthy subjects and in 55 patients with multiple myeloma. The alpha 2-macroglobulin and transferrin are significantl...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: San Miguel J,Vicente V,Battle J,Hernandez F,Lopez Borrasca A

    更新日期:1981-01-01 00:00:00

  • Economic aspects of multiple myeloma: real costs associated with disease in the Slovak Republic.

    abstract::Health care costs are continuously increasing. Multiple myeloma represents approximately 1% of all malignancies and the 5-year prevalence is 230,000 patients on average. In addition, there is an annual incidence of 3.8/100,000 in Slovakia. In total economic burden assessment, it is important to focus not only on direc...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2021_201103N1173

    authors: Babela R,Didic R,Smatana M,Fedorova K,Drgona L

    更新日期:2021-01-28 00:00:00

  • Usefulness of a multiple biomarker assay in bronchoalveolar lavage (BAL) and serum for the diagnosis of small cell lung cancer.

    abstract::To evaluate the diagnostic usefulness of simultaneous determinations of carcinoembryonic antigen (CEA), neuron specific enolase (NSE), chorionic gonadotrophin (HCG) and carbohydrate antigenic determinant 19-9 (CA 19-9), we studied 48 patients with small cell lung carcinoma (SCLC) and 15 with nonmalignant lung disease....

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Nikliński J,Chyczewska E,Furman M,Kowal E,Laudanski J,Chyczewski L

    更新日期:1993-01-01 00:00:00

  • Iron-tumor cell interaction and regulation of Ca2+ homeostasis: their implication in tumor growth.

    abstract::Using [59Fe] ferric lactate, a direct relationship between iron concentration and [59Fe] uptake by Ehrlich ascites tumor cells was found. Deferoxamine and albumin inhibited this uptake. Electrophoresis showed that both molecules complexed iron from ferric lactate. [45Ca] uptake in the presence of ferric lactate showed...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Anghileri LJ,Martinez AC,Maleki P

    更新日期:1992-01-01 00:00:00

  • Comparison of photodynamic therapy with phthalocyanine and photofrin in human colorectal carcinoma.

    abstract::Photodynamic therapy (PDT) has been developed in recent years as a new modality for the treatment of various neoplastic and non-neoplastic lesions. Although the method of combining light with photosensitizers for treatment has been around for a century, further understanding has been evolved over the past decades. The...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Stukavec J,Horak L,Duchac V,Jirasek T,Rakusan J,Karaskova M,Pouckova P

    更新日期:2008-01-01 00:00:00

  • Clinically node-positive bladder cancer: oncological results of induction chemotherapy and consolidative surgery.

    abstract::Patients with clinically node-positive bladder cancer have a poor prognosis, with many receiving only palliative chemo- therapy. We evaluated oncological results in bladder cancer patients with clinically regional and supraregional lymph- adenopathy treated with induction chemotherapy (IC) and consolidative cystectomy...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2018_170403N239

    authors: Stanik M,Poprach A,Macik D,Capak I,Maluskova D,Mareckova N,Lakomy R,Jarkovsky J,Dolezel J

    更新日期:2018-01-01 00:00:00

  • Prognostic significance of reactive changes in regional lymph nodes in gastric and mammary carcinomas.

    abstract::Regional lymph nodes in 80 cases of gastric and 70 cases of breast cancer have been examined and the reactive types have been correlated to the survival periods of the patients. In both groups of patients, a prognostically favorable sign was the detection of lymphocytic predominance combined with sinus histiocytosis, ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Riegrová D,Jansa P

    更新日期:1982-01-01 00:00:00

  • Short communication: a new technique in immunosuppression of Syrian hamsters xenografted with human tumors.

    abstract::Application of hyperimmune rabbit antisera against mouse lymphomas (6C3HED lymphoma, NK lymphoma) or against rat leukemic cells (RBA-34-Le leukemia) caused a considerable degree of lymphocyte depletion in hamsters. ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Oravec C,Ondrus B

    更新日期:1977-01-01 00:00:00

  • Early changes in flow cytometric DNA profiles induced by californium-252 neutron brachytherapy in squamocellular carcinomas of the uterine cervix.

    abstract::Ninety-five squamocellular carcinomas of the uterine cervix, clinical Stages II and III, were treated by either four schedules combining 252-californium neutron-gamma-radiotherapy with different proportions of a neutron component (9, 6 and 3 Gy) or gamma-irradiation alone. Flow cytometric DNA profiles were obtainable ...

    journal_title:Neoplasma

    pub_type: 临床试验,杂志文章

    doi:

    authors: Tacev T,Zaloudík J,Janáková L,Vagunda V

    更新日期:1998-01-01 00:00:00

  • Intensity of proliferation and sensitivity of experimental tumors to the 1-methyl-1-nitrosourea.

    abstract::The kinetics of tumor growth and cell proliferation of eleven generations of spontaneous mammary carcinoma in F1(CBA2 X C57B1/6) mice was studied. Factors responsible for different sensitivity of tumors to 1-methyl-1-nitrosourea were analyzed. The process of tumor transplantation was accompanied by the reduction in la...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Emanuel NM,Ostrovskaya LA,Krutova TV

    更新日期:1982-01-01 00:00:00