Abstract：
:Using [59Fe] ferric lactate, a direct relationship between iron concentration and [59Fe] uptake by Ehrlich ascites tumor cells was found. Deferoxamine and albumin inhibited this uptake. Electrophoresis showed that both molecules complexed iron from ferric lactate. [45Ca] uptake in the presence of ferric lactate showed the same inhibition, and an iron mass-dependence, these findings suggest an iron--cell membrane interaction as the cause of this phenomenon. The implication of iron--tumor cell membrane interaction in tumor growth regulation is discussed.
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Anghileri LJ,Martinez AC,Maleki Psubject
Has Abstractpub_date
1992-01-01 00:00:00pages
157-61issue
3eissn
0028-2685issn
1338-4317journal_volume
39pub_type
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