Iron-tumor cell interaction and regulation of Ca2+ homeostasis: their implication in tumor growth.

Abstract:

:Using [59Fe] ferric lactate, a direct relationship between iron concentration and [59Fe] uptake by Ehrlich ascites tumor cells was found. Deferoxamine and albumin inhibited this uptake. Electrophoresis showed that both molecules complexed iron from ferric lactate. [45Ca] uptake in the presence of ferric lactate showed the same inhibition, and an iron mass-dependence, these findings suggest an iron--cell membrane interaction as the cause of this phenomenon. The implication of iron--tumor cell membrane interaction in tumor growth regulation is discussed.

journal_name

Neoplasma

journal_title

Neoplasma

authors

Anghileri LJ,Martinez AC,Maleki P

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

157-61

issue

3

eissn

0028-2685

issn

1338-4317

journal_volume

39

pub_type

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