Abstract：
:Resistance to chemotherapy significantly affects the treatment results in various cancers. Multidrug resistance caused by P-glycoprotein expression is now widely studied in human malignancies. We present the results of P-glycoprotein expression examination in 91 tumor tissue samples obtained from children treated for different malignant tumors in the Dept. of Pediatric Oncology, Prague. The correlation between the level of P-glycoprotein expression and tumor histology, clinical outcome, use of therapy, relapse rate and metastatic disease was made. P-glycoprotein expression was found significantly more frequent in soft tissue sarcomas, neuroblastomas, and hepatoblastomas, and generally in disseminated disease. On the contrary, a high expression of P-glycoprotein was not found in malignant brain tumors and nephroblastomas. The data strongly support the possibility that the percentage of P-glycoprotein expressing cells in selected tumors (soft tissue sarcomas, neuroblastomas), may have a clinical importance.
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Kucerová H,Sumerauer D,Drahokoupilová E,Pisková M,Bedrnícek J,Eckschlager Tsubject
Has Abstractpub_date
2001-01-01 00:00:00pages
472-8issue
6eissn
0028-2685issn
1338-4317journal_volume
48pub_type
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