Abstract：
:Inbred Wistar rats were fed aflatoxin B1 (AFB1) during a period of 15 weeks. Some of the rats were sacrificed successively at different time intervals, and the remaining animals died a natural death. Beginning with the day of AFB1 treatment termination multifocal hepatomas appeared on the 265th day in males and on the 296th day in females. The progress of AFB1 carcinogenesis was accompanied by an ever increasing disorder of porphyrin metabolism. The content of the porphyrin fractions in primary hepatomas was greater than in the tissue of origin. Serum and hepatic GGTP activity increased with the advancement of hepatocarcinogenesis and paralleled the increase of tumor weight. The GGTP activity in hepatoma reached values exceeding those in their host liver.
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Zawirska B,Bednarz Wsubject
Has Abstractpub_date
1981-01-01 00:00:00pages
35-49issue
1eissn
0028-2685issn
1338-4317journal_volume
28pub_type
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