Abstract：
:The experiments reported in this communication examined the immunological properties of cell lines cultured under (a) normal, physiological (Cont.Cal) and (b) experimental, non-physiological (Expt.Cal) conditions described in the preceeding paper. Determination of oncogenicity, humoral and cellular immunity of the cultures at various subcultures induced in syngeneic, unconditioned CFW1 mice, showed differences between cells from the two conditions. Cells grown under the experimental conditions (Expt.Cal) became oncogenic. Oncogenicity increased with number of subcultures, and treatment with vibrio cholera neuraminidase rendered the cells non-oncogenic. It is suggested that the experimental conditions either cause malignant cell transformation, or selection of oncogenic cell variants. Since oncogenicity is reduced by treatment with neuraminidase it could be related to certain cell membrane determinants.
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Hakim AAsubject
Has Abstractpub_date
1980-01-01 00:00:00pages
449-58issue
4eissn
0028-2685issn
1338-4317journal_volume
27pub_type
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