Abstract：
:The isoquinoline peripheral benzodiazepine receptor ligand PK11195 increased drug (daunomycin)- and fluorochrome (calcein-AM) uptake and induced apoptosis detected by flow cytometry (FCM) technique, DNA electrophoretic analysis and poly(ADP-ribose) polymerase (PARP) cleavage in human multidrug-resistant myeloid leukemia (BL-60/VCR) and ovarian carcinoma (A2780/ADR) cells in vitro. The position of PK11195 with respect to drug-resistance modulator (DRM) efficiency, compared to the reference DRMs with the aid of FCM technique, was as follows: PSC833 > verapamil > PK11195 > vincristine. Our data show up to now not indicated observation that PK11195 possesses multidrug resistance modulating activity.
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Jakubikova J,Duraj J,Hunakova L,Chorvath B,Sedlak Jsubject
Has Abstractpub_date
2002-01-01 00:00:00pages
231-6issue
4eissn
0028-2685issn
1338-4317journal_volume
49pub_type
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