Abstract：
:IgA1-2 subclass distribution was determined in a series of 62 sera with diagnosed IgA paraprotein. Throughout the series the participation of IgA1 : IgA2 subclasses showed a ratio 9 : 1 even after division of the series into myeloma and nonmyeloma paraproteinemias. On dividing the series according to the antigenic type of the light chains, IgA2 paraproteins with kappa light chains predominated over the lambda type (6 : 1).
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Tichý M,Hrncír Zsubject
Has Abstractpub_date
1986-01-01 00:00:00pages
507-8issue
4eissn
0028-2685issn
1338-4317journal_volume
33pub_type
杂志文章相关文献
NEOPLASMA文献大全abstract：:A coordination complex cis-dichlorodiamminedihydroxoplatinum (IV) (oxoplatinum) was first synthesized in the USSR by Chugaev and Khlopin in 1927 [3]. Its marked antitumor properties were revealed by one of the authors of this article at the All-Union Cancer Research Center of the Academy of Medical Sciences of the USS...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:Increasing evidences have proved that circular RNAs (circRNAs), identified as a specific kind of non-coding RNAs, play a potential critical role in tumorigenesis including prostate cancer. However, the function of circRNAs in human prostate cancer remain largely unknown. In this study, we demonstrated that the express...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2019_190213N116
更新日期：2020-01-01 00:00:00
abstract：:This study aimed to identify the oncogenes associated with lung cancer based on the mRNA and single nucleotide polymorphism (SNP) profile data. The mRNA expression profile data of GSE43458 (80 cancer and 30 normal samples) and SNP profile data of GSE33355 (61 pairs of lung cancer samples and control samples) were down...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2015_117
更新日期：2015-01-01 00:00:00
abstract：:The effect of oxoplatinum on blastic transformation of human peripheral blood mononuclear cells (PBMC) was monitored following phytohemagglutinin (PHA) stimulation. The results were compared with those published in part III of the present work as well as with the effect of cisplatinum and carboplatinum on the blastic ...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:In a series of 25 patients with cervical carcinoma and 35 patients with vulvar carcinoma, clinically classified (FIGO) as Stage I and Ib, respectively, DNA ploidy and S-phase cell fraction were estimated in paraffin-embedded samples of the primary tumors and their metastases by means of flow cytometry (FCM). The two g...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:In this study subcellular localization of cyclin A in the human promyelocytic leukemia cell line HL-60 and the human erythroleukemic K-562 cell line was examined by immunocytochemical methods. Studies were based on light and electron microscope evaluations. Cyclin A at the level of light microscope was present in 48% ...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：:CD73 is a membrane-bound enzyme that catalyzes the extracellular conversion of adenosine monophosphate to adenosine. Adenosine is thought to play a role in promoting tumor growth and survival together with suppressing the host immune responses, which contribute to the multistep process of tumorigenesis. Here, we studi...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2020_190826N822
更新日期：2020-07-01 00:00:00
abstract：:Serum concentration of alpha1-proteinase inhibitor (alpha1-PI) was determined by nephelometric method in forty seven patients with liver cirrhosis (LC) and fifteen patients with hepatocellular carcinoma (HCC). Our data show an increase in the concentration of alpha1-PI in the group with decompensated LC by 17% and in ...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:The reliability of a particular in vitro parameter as potential prognostic biomarker of individual radiosensitivity is still discussed. Therefore, several in vitro radiation-induced cellular endpoints including initial, oxidative and residual DNA damage and the rate of DNA repair were assessed in peripheral blood lymp...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：:Breast cancer is one of the leading causes of cancer death in women. The Notch family of proteins plays crucial roles in determining cell fates such as proliferation, differentiation and apoptosis. A role for Notch signaling in human breast cancer has been suggested by the development of adenocarcinomas in the murine ...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：:There is some evidence that prostaglandin (PGE)-secreting cells may have a role in immunosuppression in cancer patients. In this work we investigated the effects of indomethacin--a PGE synthesis inhibitor, on PHA-induced lymphoproliferative response in vitro. Twenty patients with lung cancer before therapy were includ...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:Presented study aimed to prepare A10 aptamer-modified poly (D,L-lactic-co-glycolic acid) (PLGA) nanoparticles loaded with triplex forming oligonucleotides(TFO) for targeted prostate cancer therapy. We first synthesized a PLGA-PEG-Apt copolymer. The PLGA-PEG-Apt nanoparticles (NP-Apt) were loaded with TFO using double ...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2016_410
更新日期：2016-01-01 00:00:00
abstract：:The supernatants collected from cisplatin, lipopolysaccharide (LPS), muramyl dipeptide (MDP) or recombinant interferon gamma (rIFN-gamma) treated non-adherent mononuclear cells (with NK cell activity) enhanced thymocyte proliferation by a submitogenic concentration of concanavalin A as compared to untreated nMNC. Supe...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:Zinc finger protein 139(ZNF139), a member of zinc finger protein family, is a transcription factor. Our previous research showed ZNF139 was overexpressed in gastric cancer cells. The purpose of present study is to explore impact and mechanism of ZNF139 on metastasis by regulating invasive ability of gastric cancer cel...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2014_037
更新日期：2014-01-01 00:00:00
abstract：:Heat Shock proteins 70 (Hsp70) is a family of highly conserved molecules that maintain the function of crucial cellular pathways during stress. Hsp70 derived from tumor cells is bound with tumor antigenic peptides from the diverse antigen cytosolic pool. Tumor-derived Hsp70 preparations after ex vivo administration pe...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2009_03_259
更新日期：2009-01-01 00:00:00
abstract：UNLABELLED:In a phase II clinical study, pretreated multiple myeloma patients with relapsing or stable disease received autologous anticancer vaccine containing dendritic cells loaded with Id-protein. Patients received a total of 6 vaccine doses intradermally in monthly intervals. No clinical responses were observed. D...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2012_057
更新日期：2012-01-01 00:00:00
abstract：:In 115 patients with chronic lymphocytic leukemia (CLL), grouped according to the staging system as proposed by Rai et al., dipeptidylpeptidase II (DPP II) reaction was carried out in smears of peripheral blood using Lys-Pro-MNA and Lys-Ala-MNA as substrates and Fast Blue B (FBB) as the coupling agent in cacodylate bu...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:Drug resistance is a prominent problem of cancer therapy. Differences in quantity and quality of many metabolites in normal and malignant cells and their changes after treatment by anticancer drugs can be detected by nuclear magnetic resonance (NMR) both in vivo and in vitro. The results of in vivo and in vitro 1H, 13...
journal_title：Neoplasma
pub_type： 杂志文章,评审
doi：
更新日期：1998-01-01 00:00:00
abstract：:The anti-tumor effects of i.p. administered cyclooxygenase inhibitor - diclofenac and i.v. administered liposomal muramyl tripeptide phosphatidylethanolamine (MTP-PE) were investigated using a s.c. growing murine fibrosarcoma tumor. Tumor growth was assessed by measuring tumor volumes and survival of the mice. Both of...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:Very few studies have determined the prognostic value of interim and restaging PET/CT in patients with Hodgkin lymphoma using current standard of care therapy outside clinical trials. We analyzed the effect of the results of interim and restaging PET/CT on the survival (overall- and relapse-free) in patients who recei...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2015_075
更新日期：2015-01-01 00:00:00
abstract：:Human leukocyte antigen - G (HLA-G) is a non-classical HLA class I antigen with restricted distribution in normal tissues. Ectopic HLA-G expression observed at some pathological circumstances as malignant transformation might be triggered by epigenetic modifications such as DNA demethylation. Recently it was demonstra...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2009_06_514
更新日期：2009-01-01 00:00:00
abstract：:Bladder cancer (BCa) is a common carcinoma of the urinary tract which occurs in the bladder mucosa. In recent years, people have recognized that epigenetic changes such as DNA methylation play important roles in the development of BCa, but the specific mechanism is unclear. In this study we detected the methylation ra...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2020_200928N1035
更新日期：2021-01-14 00:00:00
abstract：:Mammalian target of rapamycin (mTOR) has two subtypes, i.e., mTORC1 and mTORC2, which contain the Raptor and Rictor core molecules, respectively. The effect of Raptor and Rictor on hypoxia inducible factor (HIF)-1α, HIF-2α, and vascular endothelial growth factor (VEGF) in colorectal cancer (CRC) is unclear. In this wo...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2020_190705N597
更新日期：2020-05-01 00:00:00
abstract：:In a group of 11,153 autopsied subjects a higher number of cholecystectomies was found in both sexes in individuals with large intestine tumors as compared with the rest of the autopsied persons without tumors (p less than 0.001). The results confirmed the hypothesis that cholecystectomy is a supporting factor in the ...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:The aim of the study was to evaluate the expression of activated mammalian rapamycin (mTOR) and its downstream effectors, phosphorylated p70 ribosomal protein S6 kinase (p70S6K) and eukaryotic initiation factor 4E-binding protein 1 (4EBP1), in intrahepatic cholangiocarcinomas (ICC), in order to strengthen the rational...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2012_018
更新日期：2012-01-01 00:00:00
abstract：UNLABELLED:Antiangiogenic drugs are approved for many cancer types for longer than a decade. Furthermore, several antiangiogenic agents are approved for local application in ophthalmology for treatment of macular degeneration, venous retinal occlusion and diabetic retinopathy. Knowing that antiangiogenic agents are act...
journal_title：Neoplasma
pub_type： 杂志文章,评审
doi：
更新日期：2016-01-01 00:00:00
abstract：:DNA repair synthesis following dimethylnitrosamine (DMN) treatment in mouse liver was detected in vivo by means of histoautoradiography. This phenomenon was more significant around the acinus center (practically in all hepatocytes) than around the portobiliary space. Besides this also a decrease in semiconservative DN...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：:MiR-34a acts as a tumor suppressor in various malignancies. In HNSCC, the role of miR-34a in proliferation has not been fully elaborated and the target genes are still bind. Here, we addressed that forced miR-34a expression induced cell cycle arrest and senescence. Hypoxia/HIF1α was found to negatively correlate to th...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2017_408
更新日期：2017-01-01 00:00:00
abstract：:Acyclic nucleotide analogs (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA) and 9-(2-phosphonylmethoxyethyl)adenine (PMEA) were phosphorylated in the presence of ribonucleoside 5'-triphosphates by the crude extract from mouse leukemia cells L1210 affording the respective mono- and diphosphoryl derivatives. T...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:The study was aimed at the proper detection of surface and cytoplasmic clonal Ig light/heavy chains in the frame of multiparameter flow cytometry analysis of some B-cell malignancies. An exact direct evidence has been obtained that the leukemia cells following staining by antibodies to immunoglobulins will need to be ...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
