Abstract：
:Acyclic nucleotide analogs (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA) and 9-(2-phosphonylmethoxyethyl)adenine (PMEA) were phosphorylated in the presence of ribonucleoside 5'-triphosphates by the crude extract from mouse leukemia cells L1210 affording the respective mono- and diphosphoryl derivatives. The donor efficiency was decreasing in the order CTP greater than UTP greater than ATP greater than GTP. The presence of an ATP regenerating system stimulated considerably the conversion of both compounds. The rate of PMEA phosphorylation was 5-times slower than that of HPMPA both with and without an ATP regenerating system.
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Merta A,Veselý J,Votruba I,Rosenberg I,Holý Asubject
Has Abstractpub_date
1990-01-01 00:00:00pages
111-20issue
2eissn
0028-2685issn
1338-4317journal_volume
37pub_type
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