Abstract：
:HCC (hepatocellular carcinoma), which can be induced by cirrhosis and viral hepatitis infection, is the most frequent form of liver cancer. This study is performed to investigate the mechanisms of HCC. GSE57957 was obtained from Gene Expression Omnibus database, including 39 HCC samples and 39 adjacent non-tumorous samples. The DEGs (differentially expressed genes) were screened using the limma package in R, and then were conducted with enrichment analysis using "BioCloud" platform. Using STRING database, WebGestalt tool, as well as ITFP and TRANSFAC databases, PPI (protein-protein interaction) pairs, miRNA (microRNA)-target pairs, and TF (transcription factor)-target pairs separately were predicted. Followed by integrated network was constructed by Cytoscape software and module analysis was performed using the MCODE plugin of Cytoscape software. There were 518 DEGs identified from the HCC samples, among which 17 up-regulated genes (including MCM2, MCM6, and CDC20) and 5 down-regulated genes could also function as TFs. In the integrated network for the down-regulated genes, FOS and ESR1 had higher degrees, and both of them were targeted by miR-221 and miR-222. Additionally, MCM2 had interaction with MCM6 in the up-regulated module with the highest score. MCM2, MCM6, CDC20, FOS, ESR1, miR-221 and miR-222 might affect the pathogenesis of HCC.
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Shi SQ,Ke JJ,Xu QS,Wu WQ,Wan YYdoi
10.4149/neo_2018_161215N642subject
Has Abstractpub_date
2018-01-01 00:00:00pages
66-74issue
1eissn
0028-2685issn
1338-4317journal_volume
65pub_type
杂志文章相关文献
NEOPLASMA文献大全abstract：:The aim of this study was to evaluate the clinical and pathological features of breast cancer patients with bilateral breast cancer and to assess the impact of the second breast cancer on their prognosis. Thirty six breast cancer patients with bilateral (metasynchronous) cancer were treated in Greatpoland Cancer Cente...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:Drug resistance is a prominent problem of cancer therapy. Differences in quantity and quality of many metabolites in normal and malignant cells and their changes after treatment by anticancer drugs can be detected by nuclear magnetic resonance (NMR) both in vivo and in vitro. The results of in vivo and in vitro 1H, 13...
journal_title：Neoplasma
pub_type： 杂志文章,评审
doi：
更新日期：1998-01-01 00:00:00
abstract：:Six established human sarcoma cell lines (giant cell tumor of bone B-5GT, fibrosarcoma, B-6FS, cystosarcoma phylloides B-19CS, synovial sarcoma U-4SS and two osteogenic sarcomas U-20S and U-393OS) have been studied and compared to the normal B-41FB fibroblastic cells and the HeLa cells. For cytogenetic and isoenzyme c...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:Health care costs are continuously increasing. Multiple myeloma represents approximately 1% of all malignancies and the 5-year prevalence is 230,000 patients on average. In addition, there is an annual incidence of 3.8/100,000 in Slovakia. In total economic burden assessment, it is important to focus not only on direc...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2021_201103N1173
更新日期：2021-01-28 00:00:00
abstract：:Prolonged lifespan of monoclonal lymphocytes in B-cell lymphocytic leukemia (B-CLL) arises from their resistance to programmed cell death. In contrast, when cultured in vitro, B-CLL tumour cells rapidly undergo apoptosis. There is mounting evidence that P-glycoprotein (P-gp), an adenosine triphosphate-binding cassette...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:The age of patients, type of tumor growth, pretreatment hematocrit, and radiation-induced tumor regression were evaluated as possible prognostic factors in 222 patients with advanced cervical cancer treated at the Institute of Clinical Oncology in Bratislava in the period from 1960 through 1980. The five-year disease-...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:The paclitaxel represents first agent from novel class of antineoplastic drugs-taxoids. The clinical development of paclitaxel was initially hampered by hypersensitivity reactions. Current dosage regiments with premedication reduced the incidence of these side effects to less than 3%. The major dose-limiting adverse e...
journal_title：Neoplasma
pub_type： 杂志文章,评审
doi：
更新日期：1996-01-01 00:00:00
abstract：:The macrocyclic Cu(II)-tetraanhydroaminobenzaldehyde complex Cu(TAAB)C12 induces various cytotoxic effects in the dependence on a cell line, concentration and time of exposition. The highest complex concentration of 914 nmol/l induces degeneration of certain part of the HeLa cells population after 24 hours of cultivat...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:We processed data of 79 patients (pts) with malignant lymphoma from the National Registry of haematopoietic stem cell transplants conducted between 1997 and 2006. The haematopoietic stem cell donor in 48 pts was an HLA matched relative, and in 30 pts an unrelated volunteer. Sixty (77%) pts were transplanted with reduc...
journal_title：Neoplasma
pub_type： 杂志文章,多中心研究
doi：10.4149/neo_2009_01_76
更新日期：2009-01-01 00:00:00
abstract：:Loss of heterozygosity (LOH) has been shown to be an important prognostic factor in a variety of malignant neoplasm's. Cervical cancer develops as result of multiple genetic alterations. The aim of this study was to analyze presence of LOH in cervical cancer and to identify the correlation between LOH and survival and...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:This paper summarizes preliminary results of combining suicide gene strategy (E. coli cytosine deaminase gene--CD) with immunotherapy (murine interleukin-4 gene) for treatment of experimental B16(F10) melanomas implanted into C57Bl/6 mice. The best therapeutic results, inhibition of tumor growth and prolonged survival...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:During the course of 16 years, i. e. from 1953 to 1968 inclusively, a total of 2111 patients with carcinoma of the uterine cervix were treated at the Oncological Institute in Brno. Of these, 1829 patients, i. e. 86.6% were irradiated, 282, i. e. 13.4% underwent primarily a radical excision and subsequently were irradi...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：PURPOSE:To explore the expression of the TRAV gene in peripheral blood mononuclear cells (PBMCs) and in tumor-infiltrating lymphocytes (TILs) in the patients with breast cancer using a DNA melting curve (FQ-PCR) technique for T cell receptor (TCR) alpha chain CDR3 spectratyping. Peripheral blood samples and tissue samp...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2012_088
更新日期：2012-01-01 00:00:00
abstract：:By the use of the dextran-coated charcoal method the presence of a high-affinity binding site for benzo(a)pyrene in the cytosol from rat liver (R strain) has been demonstrated. This binder was saturable by ligand concentration and by time. Sucrose density gradient analysis after charcoal treatment revealed one major p...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:Nodal metastasis is an important prognostic indicator in head and neck cancers, including salivary carcinomas. In these, the risk for lymph node metastasis is variable and strongly associated with the tumor histologic type. The aim of the current study was to evaluate the lymphatic vessel density (LVD) and expressions...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2011_04_331
更新日期：2011-01-01 00:00:00
abstract：:The cytostatic activity of 2-thio-4-hydrazinouracil (THU) on some transplantable tumors has been studied. A strong effect of this compound (between 60% and 100% suppression) has been found in the case of Myeloma P-8 (MOPC-21) and Sarcoma 180 (Crocker). A less pronounced effect has been observed on Yoshida sarcoma, whi...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1975-01-01 00:00:00
abstract：:This study is intended to investigate the role of Tripartite Motif (TRIM) 31 in glioma. Immunohistochemistry and western blot analysis showed that TRIM31 was overexpressed in high-grade glioma tissues. Univariate survival analysis indicated that high expression of TRIM31 was related to short survival time of glioma pa...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2019_190106N21
更新日期：2019-09-01 00:00:00
abstract：:Immune complexes (IC) were examined in the sera of 100 patients with histologically confirmed non-Hodgkin's lymphoma (NHL) and 80 leukemic patients by the EA-rosette forming cell inhibition assay. Sera from 55 healthy controls were also tested for the presence of IC. Using 9% rosette inhibition as a base-line, IC were...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:Glioma is among the most fatal brain tumors characterized by a highly malignancy and rapid progression and early metastasis. Dysregulation of long non-coding RNA differentiation antagonizing non-protein coding RNA (LncRNA DANCR) is associated with the development, progression and metastasis of various cancers. In the ...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2018_170724N498
更新日期：2018-09-19 00:00:00
abstract：:The aim of the study was to evaluate the expression of activated mammalian rapamycin (mTOR) and its downstream effectors, phosphorylated p70 ribosomal protein S6 kinase (p70S6K) and eukaryotic initiation factor 4E-binding protein 1 (4EBP1), in intrahepatic cholangiocarcinomas (ICC), in order to strengthen the rational...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2012_018
更新日期：2012-01-01 00:00:00
abstract：UNLABELLED:In a phase II clinical study, pretreated multiple myeloma patients with relapsing or stable disease received autologous anticancer vaccine containing dendritic cells loaded with Id-protein. Patients received a total of 6 vaccine doses intradermally in monthly intervals. No clinical responses were observed. D...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2012_057
更新日期：2012-01-01 00:00:00
abstract：:Addition of trastuzumab to chemotherapy is the cornerstone of adjuvant treatment of early HER2 positive breast cancer. Clinical trials and metaanalyses of adjuvant trastuzumab have shown significant reduction in risk of recurrence and death. Nevertheless, the real magnitude of the effect of any drug must be reevaluate...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2016_513
更新日期：2016-01-01 00:00:00
abstract：:Laryngeal carcinoma is the second commonest head and neck carcinoma globally. MicroRNA-101 (miR-101) has been reported as a tumor suppressor in multiple malignancies including laryngeal squamous cell carcinoma (LSCC). However, the roles and molecular mechanisms of miR-101 in the development of LSCC have not been fully...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2018_180811N611
更新日期：2019-07-23 00:00:00
abstract：:Authors evaluated the prevalence of symptoms of the metabolic syndrome and insulin resistance in 25 patients with adrenal incidentalomas (10 men, 15 women) of the mean age 57.9+/-15 years. 15 patients had adrenal adenoma determined by CT or MR scan and 10 had unilateral or bilateral hyperplasia. The prevalence of obes...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:The distribution study of zinc phthalocyanine disulfonate (ZnPcS2) in nude mice bearing mammary carcinoma (T50/80) revealed a rapid uptake of the dye by tumor. In experimental photodynamic therapy (PDT), the tumors were exposed to laser radiation (670 nm, 100 mW/cm2, 150 J/ /cm2) after intravenous administration of Zn...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:In our earlier report on circulating immune complexes (CIC) from sera of patients with Hodgkin's disease (HD), we demonstrated disease-associated increase in the intensity of a 40kD (pl 5.6) polypeptide in the CIC. In extension of these investigations, we now report that the 40kD moiety exists in CIC as a complex with...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:Progressive ascitic growth of a spontaneous transplantable T-cell lymphoma, designated as Dalton's lymphoma (DL), in a murine host has been shown to be associated with an involution of thymus accompanied by a massive depletion of the cortical region and an alteration in the distribution of thymocytes by a decrease of ...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:Sentinel node biopsy becomes a standard diagnostic and therapeutic tool in breast cancer in certain indications, while in other indications its validity is still reviewed. The authors present their experience with this method. In the years 2000-2006 700 patients underwent surgery. 704 sentinel node biopsies were perfo...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：:Circulating tumor cells (CTCs) represent a potential non-invasive substitute for real-time tissue biopsy. Moreover, detection of CTCs in breast cancer patients has been reported as a strong prognostic factor. Biomarkers on CTCs have been analysed and correlated to tissue biopsies from breast cancer patients. Discordan...
journal_title：Neoplasma
pub_type： 杂志文章,评审
doi：10.4149/neo_2016_003
更新日期：2016-01-01 00:00:00
abstract：:Karyograms of the primary hepatomas induced in Wistar rats by aflatoxin b1 exhibited hypodiploid chromosome sets, and destruction of the chromosomes. Cytophotometric investigations showed a decrease of DNA content in the neoplastic cells, even to about 40% of DNA content in the normal hepatocytes in rats. In the neopl...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
