Circulating immune complexes in Hodgkin's disease. Reactivity of IgG isolated from circulating immune complexes.

Abstract:

:In our earlier report on circulating immune complexes (CIC) from sera of patients with Hodgkin's disease (HD), we demonstrated disease-associated increase in the intensity of a 40kD (pl 5.6) polypeptide in the CIC. In extension of these investigations, we now report that the 40kD moiety exists in CIC as a complex with IgG, and that IgG isolated from such CIC samples from sera of patients with HD shows preferential reactivity with the typical large binucleate Reed-Sternberg (R-S) cells in the sections of disease-involved lymph nodes from HD patients.

journal_name

Neoplasma

journal_title

Neoplasma

authors

Nerurkar AV,Advani SH,Gothoskar BP

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

87-91

issue

2

eissn

0028-2685

issn

1338-4317

journal_volume

40

pub_type

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