Abstract:
:The growth of solid tumors and their metastasis is dependent on the development of new blood vessels (angiogenesis). In our previous studies it was found that angiogenesis inhibitor TNP-470 acting systematically can decrease the rate of growth of transplantable Bomirski Abmelanoma in hamsters. In this study we applied TNP-470 (30 mg/kg) peritumorally from the day when tumor was palpable over 10 days, once daily. Animals were killed 6 months later and examination by autopsy and histological preparations showed the complete remission of transplanted tumor and the lack of metastasis. Thus, Ab melanoma can be effectively cured with TNP-470 angiogenesis inhibitor when the substance is applied locally.
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Myśliwski A,Koszałka P,Bigda J,Szmit Esubject
Has Abstractpub_date
2002-01-01 00:00:00pages
319-22issue
5eissn
0028-2685issn
1338-4317journal_volume
49pub_type
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