Results of radiotherapy and combined radiotherapy and chemotherapy of inoperable lung cancer.

Abstract:

:In this study there is presented a comparative analysis of immediate results after radiotherapy and combined treatment (radio- and chemotherapy) in 174 patients with highly differentiated inoperable lung cancer. The data were provided by participants of a joint investigation in some CMEA member countries (Hungary, USSR, Czechoslovakia) during the period of 1976 to 1980. In the randomized study radiotherapy (a total dose of 60 Gy) was applied in 98 patients, radiotherapy with chemotherapy (methotrexate and 5-fluorouracil) was applied in 76 patients. The comparative analysis showed that the employment of complementary chemotherapy tend to improve the immediate therapeutic effects. In the case of highly differentiated planocellular carcinoma a pronounced positive effect was seen in 48.6% of patients as compared to the 31.2% of those treated with radiotherapy alone. Nevertheless, with respect to survival rate prolongation, these differences are not manifested in favor of the combined method of treatment. After a conservative treatment (radiotherapy and radiotherapy in combination with chemotherapy) of patients with differentiated types of inoperable lung cancer there was a one-year survival rate of 55.7%, 17.27% of the patients survived for 2 years, and 8.55% for 3 years. In radiotherapy applied alone as in the combined method as well, a direct dependence of survival rate prolongation on immediate therapeutical effects was detected. For more than 1 year survived 49 patients (73.1%) out of 67 exhibiting pronounced immediate effects, and for 3 years survived 8 patients out of 9.

journal_name

Neoplasma

journal_title

Neoplasma

authors

Kiseleva ES,Pitskhelauri VG,Trakhtenberg AK,Daryalova SL,Kasyanenko IV,Zakharchenkov AV,Lebedev VA,Zvekotkina LS,Glagolev AN,Bidyak IP

subject

Has Abstract,Author List Incomplete

pub_date

1983-01-01 00:00:00

pages

573-80

issue

5

eissn

0028-2685

issn

1338-4317

journal_volume

30

pub_type

临床试验,杂志文章,随机对照试验
  • Immunological reactivity in the lymph nodes of the host following experimental cancer immunotherapy utilizing polymerized autologous tumor tissue particles.

    abstract::The effects of the specific active cancer immunotherapy utilizing autologous tumor tissue particles polymerized with ethylchlorformiate on the immune system of the host were evaluated in DBA/2 mice bearing a malignant mast cell tumor, mastocytoma (P-815 X 2), with the special emphasis placed on the morphologic changes...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Syrjänen KJ,Soimakallio S

    更新日期:1980-01-01 00:00:00

  • Production of plasminogen activator and inhibition of embryonic cell aggregation by cultured human normal and neoplastic cells.

    abstract::The plasminogen activator (PA) production and the capacity to inhibit embryonic neural retina (NR) cell aggregation by human normal and neoplastic cell lines have been studied. The PA production was detected by both iodinated fibrin and casein lysis assays, and by changes in cell morphology at the presence of activate...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Phan Thu A,Popovic M

    更新日期:1979-01-01 00:00:00

  • FAB classification of chronic myelomonocytic leukemia: heterogeneity revealed on the basis of bone marrow findings.

    abstract::We report on 12 patients who fulfilled the FAB diagnosis criteria of chronic myelomonocytic leukemia (CMML). Some clinical findings (splenomegaly) as well as biological parameters (WBC count, cellularity of bone marrow sections, presence of dyserythropoiesis in bone marrow smears) were subjected to particular analysis...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Yavòrkovsky LL,Solovei DY,Ryauzova LY,Schvidel LM,Zile MA,Sused SG,Teilane IY

    更新日期:1988-01-01 00:00:00

  • Downregulation of CDC20 suppressed cell proliferation, induced apoptosis, triggered cell cycle arrest in osteosarcoma cells, and enhanced chemosensitivity to cisplatin.

    abstract::Osteosarcoma (OS) is a common malignant bone tumor that occurs in adolescents or children under the age of 20, which is extremely difficult to cure and has a high recurrence rate. Recent studies showed that cell division cycle 20 (CDC20) overexpression is associated with poor prognosis in patients with osteosarcoma. H...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2020_200614N629

    authors: Gao Y,Guo C,Fu S,Cheng Y,Song C

    更新日期:2020-10-30 00:00:00

  • Glutathione peroxidase, reduced glutathione, superoxide dismutase and catalase in red cells of patients with hairy cell leukemia.

    abstract::Red cell antioxidant enzymes have been recently studied in malignant lymphomas and the results are controversial. Hairy cell leukemia is a rare chronic lymphoproliferative disorder originating probably in a pluripotent stem cell. In the present study, glutathione peroxidase (Gpx), reduced glutathione (GSH), superoxide...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Arruda VR,Salles TS,Costa FF,Saad ST

    更新日期:1996-01-01 00:00:00

  • The intermediate filaments and prognostically oriented morphological classification in ductal breast carcinoma.

    abstract::The expression of cytokeratins 7, 8, 14, 18, 19 and vimentin was examined in 100 cases of ductal invasive breast carcinomas. While the predominantly diffuse immunohistological positivity of simple epithelia cytokeratins 7 (in 93), 8 (in 100), 18 (in 100) and 19 (in 97) cases represents a constant feature of these tumo...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Rejthar A,Nenutil R

    更新日期:1997-01-01 00:00:00

  • Estimation of oncostatin M (OSM) secretion by peritoneal macrophages with regard to the progression of transplantable melanomas.

    abstract::The authors have studied the influence of two kinds of transplantable melanomas on the secretion of oncostatin M (OSM) and total proteins by peritoneal macrophages. Culture supernatant samples were tested by ELISA. The macrophages of melanoma-bearing animals released a lower amount of OSM than those of the controls. A...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Kozłowska K,Cichorek M,Zarzeczna M

    更新日期:1998-01-01 00:00:00

  • The novel exon 11 mutation of BRCA1 gene in a high-risk family.

    abstract::Germline mutations in the BRCA1 and BRCA2 genes are required for the initiation of the development of hereditary forms of breast and ovarian cancer, which represent 10-15% of all cases. The course of the disease varies from case to case that can be due even to the possibility of multiple genetic changes including inac...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Cierniková S,Tomka M,Sedláková O,Reinerová M,Stevurková V,Kovác M,Cente M,Ilenciková D,Bella V,Zajac V

    更新日期:2003-01-01 00:00:00

  • Inhibition of cell-mediated cytotoxicity against tumor-associated antigens by suppressor lymph node cells from mice bearing methylcholanthrene-induced sarcomas.

    abstract::Suppression of cell-mediated cytotoxicity directed against tumor-associated membrane antigens of methylcholanthrene (MC)-induced sarcomas by lymph node cells (LNC) from tumor-bearing mice was examined by inhibition of the 3H-thymidine incorporation assay. Normal LNC from B10 mice had been sensitized in vitro by 6-day ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Indrová M,Bubeník J

    更新日期:1979-01-01 00:00:00

  • MiR-129-5p is down-regulated and involved in migration and invasion of gastric cancer cells by targeting interleukin-8.

    abstract::Expression of microRNA-129-5p (miR-129-5p) has been reported to decrease in gastric cancer (GC). However, little information is available about how miR-129-5p affects cell migration and invasion of GC. Cancer samples and matched non-tumor adjacent tissues were obtained from patients with GC. Besides, peripheral blood ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2016_503

    authors: Jiang Z,Wang H,Li Y,Hou Z,Ma N,Chen W,Zong Z,Chen S

    更新日期:2016-01-01 00:00:00

  • Prognostic validation of the WHO 2010 grading system in pancreatic insulinoma patients.

    abstract::The purpose of this study was to evaluate the prognostic potential of the World Health Organization (WHO) 2010 grading system in patients with pancreatic insulinomas. This was a retrospective study that analyzed the overall survival of 85 pancreatic insulinoma patients treated at our Institute between May 2002 and Mar...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2015_058

    authors: Wang L,Yang M,Zhang Y,Xu S,Tian BL

    更新日期:2015-01-01 00:00:00

  • Clinical significance of the plasminogen activator system in relation to grade of tumor and treatment response in colorectal carcinoma patients.

    abstract::Urokinase (uPA) plays an essential role in the activation of plasminogen to plasmin, and together with its receptor (uPAR), tissue activator (tPA) and urokinase inhibitors (PAI 1, PAI 2, PAI 3 and protease nexin) forms the plasminogen activator system (PAS), a component of metastatic cascade importantly contributing t...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2011_05_377

    authors: Halamkova J,Kiss I,Pavlovsky Z,Tomasek J,Jarkovsky J,Cech Z,Tucek S,Hanakova L,Moulis M,Zavrelova J,Man M,Benda P,Robek O,Kala Z,Penka M

    更新日期:2011-01-01 00:00:00

  • Incidence of childhood tumors in Slovakia.

    abstract::During the decade 1968-1977 a total of 1488 cases of neoplasms were registered in Slovakia in children aged 0-14 years giving an average annual age-specific rate of 120.7 per million. Tumors prevailed in boys with 131.2 in comparison with girls showing 109.7 incidence rate/10(6). The most common malignancies were leuk...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Plesko I,Somogyi J,Dimitrova E

    更新日期:1983-01-01 00:00:00

  • Synergistic apoptotic effect of arabinoxylan rice bran (MGN-3/Biobran) and curcumin (turmeric) on human multiple myeloma cell line U266 in vitro.

    abstract::The present study was carried out to investigate the synergistic apoptotic potential of arabinoxylan rice bran (MGN-3/Biobran) and curcumin (turmeric) on human multiple myeloma (MM) cell line U266 , in vitro. U266 cells were cultured with MGN-3 (50 or 100μg/ml) and curcumin (2.5-10μM) for 3 days. The effects of MGN-3 ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2011_02_118

    authors: Ghoneum M,Gollapudi S

    更新日期:2011-01-01 00:00:00

  • Training of prescreening cytotechnicians. A report on 10-year experience.

    abstract::Institutional training of prescreening cytotechnicians started in 1972 in the Research Institute of Oncopathology, Budapest. Up to 1983 ten classes, i.e. 230 students have been trained. Authors acknowledge the good achievements of their students and state that the diagnostic reliability of the qualified cytotechnician...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Arva P,Bodó M,Sugár J

    更新日期:1984-01-01 00:00:00

  • The FBXW7 tumor suppressor inhibits breast cancer proliferation and promotes apoptosis by targeting MTDH for degradation.

    abstract::Metadherin (MTDH) is an oncoprotein and is expressed at high levels in a wide variety of human carcinomas, which represents an important genetic determinant and regulates multiple events in tumorigenesis. MTDH promotes breast cancer cell proliferation and tumorigenesis through the activation of numerous signaling path...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2018_170228N149

    authors: Chen X,Li XY,Long M,Wang X,Gao ZW,Cui Y,Ren J,Zhang Z,Liu C,Dong K,Zhang H

    更新日期:2018-01-01 00:00:00

  • Chloronitroimidazoles as radiosensitizers of hypoxic cells in vitro.

    abstract::Some results of the first more complex studies in vitro on radio-sensitizing efficiency, cytotoxicity and reactivity with blood-thiols of a series of 4- or 5-nitroimidazoles substituted in the 5, 4 or 2 position with chlorine are presented. The derivatives of 4-nitroimidazole substituted in 5 position ("ortho" positio...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Wideł M,Watras J,Suwiński J,Salwińska E

    更新日期:1987-01-01 00:00:00

  • In vitro and in vivo effects of reovirus on HPV16-transformed mice cells.

    abstract:UNLABELLED:Oncolytic viruses are examined to serve as anticancer therapeutics. It is expected that in addition to direct oncolytic effect their action will also help eliciting a solid antitumor immunity. In presented series of experiments we have employed two HPV16-transformed mouse (strain C57/B6) cell lines, TC-1 and...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2010_03_207

    authors: Figova K,Sobotkova E,Duskova M,Ludvikova V,Vonka V,Eckschlager T

    更新日期:2010-01-01 00:00:00

  • Cellular stress response in Eca-109 cells inhibits apoptosis during early exposure to isorhamnetin.

    abstract::The flavonol aglycone isorhamnetin shows anti-proliferative activity in a variety of cancer cells. Previous work, from our laboratory showed that isorhamnetin inhibits the proliferation of human esophageal squamous carcinoma Eca-109 cells in vitro, but only after 72 h of exposure. This led us to propose that isorhamne...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2012_047

    authors: Shi C,Fan LY,Cai Z,Liu YY,Yang CL

    更新日期:2012-01-01 00:00:00

  • Intensity of proliferation and sensitivity of experimental tumors to the 1-methyl-1-nitrosourea.

    abstract::The kinetics of tumor growth and cell proliferation of eleven generations of spontaneous mammary carcinoma in F1(CBA2 X C57B1/6) mice was studied. Factors responsible for different sensitivity of tumors to 1-methyl-1-nitrosourea were analyzed. The process of tumor transplantation was accompanied by the reduction in la...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Emanuel NM,Ostrovskaya LA,Krutova TV

    更新日期:1982-01-01 00:00:00

  • The reaction of Cytembena with cellular thiol compounds.

    abstract::Cytembena has been shown to undergo a rapid addition reaction with a number of thiol compounds, including glutathione and cysteine, resulting in alkylation of the sulphur. Administration of Cytembena to Yoshida sarcoma cells and to L1210 leukemia cells resulted in a loss of titratable thiol groups within the cells, th...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Jackson RC,Taylor GA,Harrap KR

    更新日期:1976-01-01 00:00:00

  • AFP role in predicting recurrence of hepatocellular carcinoma after living donor liver transplantation in HCV patients.

    abstract::HCC is one of the leading causes of death worldwide. Liver transplantation including living donor transplantation is the best available treatment. We have analyzed our experience with LDLT in patients with HCC and HCV in order to determine if alpha feto-protein (AFP) is a better predictor of recurrence than the tumor ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2018_170315N184

    authors: Komorowski AL,Hsu CC,Julka KD,Vasavada B,Lin CC,Wang CC,Chen CL

    更新日期:2018-03-14 00:00:00

  • Anal cancer chemoirradiation with curative intent - a single institution experience.

    abstract:UNLABELLED:Results of radiochemotherapy in 50 patients with squamous cell carcinoma of the anal canal, treated with radical radiochemotherapy between January 2003 and September 2007, at the Institute of Oncology Ljubljana are presented. The treatment schedule consisted of 3-D conformal external beam radiotherapy (45 Gy...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2009_02_150

    authors: Oblak I,Petric P,Anderluh F,Velenik V,Hudej R,Fras AP

    更新日期:2009-01-01 00:00:00

  • Distribution of subclasses in a series of 62 sera with IgA paraprotein.

    abstract::IgA1-2 subclass distribution was determined in a series of 62 sera with diagnosed IgA paraprotein. Throughout the series the participation of IgA1 : IgA2 subclasses showed a ratio 9 : 1 even after division of the series into myeloma and nonmyeloma paraproteinemias. On dividing the series according to the antigenic typ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Tichý M,Hrncír Z

    更新日期:1986-01-01 00:00:00

  • In vitro studies of a co-carcinogenic effect of vaccinia and herpes group viruses.

    abstract::The results of studies of a co-carcinogenic effect of two human infectious viruses in tissue culture are reported here. Viable vaccinia virus actively replicating in the cells of primary BALB/c tissue culture and in a number of continuous murine cell lines has been shown to induce in them expression of major structura...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Mazurenko NP,Merekalova ZI,Pavlish OA,Bykovsky AF,Kurzman MJ,Mazurenko NN

    更新日期:1981-01-01 00:00:00

  • MMP-9 as a potential biomarker for carcinoma of oral cavity: a study in eastern India.

    abstract::Carcinoma of oral cavity have a high risk of recurrence after initial treatment with surgery, radiotherapy, surgery with adjuvant radiotherapy, or radio-chemotherapy.The present study investigated the changes in expression, activity and regulation of matrix metalloproteinases (MMP) -2 and -9 in oral squamous cell carc...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2014_091

    authors: Nanda DP,Dutta K,Ganguly KK,Hajra S,Mandal SS,Biswas J,Sinha D

    更新日期:2014-01-01 00:00:00

  • The efficacy and reliability of lung protection during total body irradiation of patients with disseminated malignancies.

    abstract::The main problem in total body irradiation (TBI) is obtaining a homogenous dose distribution inside the whole irradiated body and ensuring appropriate dose reduction in the lungs. The process of irradiation should be comfortable for the patients and repeatable despite the size and age diversity among patients. The aim...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Malicki J,Skrobala A,Kosicka G,Wachowiak J

    更新日期:2005-01-01 00:00:00

  • Breast and other cancer deaths in a mental hospital.

    abstract::The neuroleptics, well known as stimulants of prolactin release, are supposed to increase breast cancer incidence. To verify this hypothesis, we selected a group of 853 deaths of female inpatients with mental diseases recorded in the Dr. G. Marinescu Hospital between 1929 and 1978. Using proportionally and indirect st...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Costa D,Mesteş E,Coban A

    更新日期:1981-01-01 00:00:00

  • Serum and urinary levels of CD222 in cancer: origin and diagnostic value.

    abstract::The mannose 6-phosphate/insulin-like growth factor 2 receptor (CD222, M6P/IGF2R) is a multifunctional transmembrane type I receptor, mostly localized intracellularly, less on the surface of all types of mammalian cells. It is known both to transport lysosomal enzymes through their mannose 6-phosphate moieties and to i...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2018_171203N792

    authors: Vicikova K,Petrovcikova E,Manka P,Drach J,Stockinger H,Leksa V

    更新日期:2018-09-19 00:00:00

  • Effect of inhibition of DNA synthesis on recovery of X-irradiated L5178Y-S cells, II. 9-beta-D-arabinofuranosyladenine.

    abstract::The effects of 9-beta-D-arabinofuranosyladenine (araA) on radiosensitivity, postirradiation changes in the cell cycle distribution and DNA synthesis in mouse L5178Y-S lymphoma cells are described. Increase in the araA concentration (from 25 to 200 mumol/l) was is correlated with reduction in clonogenic survival except...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Kapiszewska M,Lange CS

    更新日期:1989-01-01 00:00:00