Olfactomedin 4, a novel marker for the differentiation and progression of gastrointestinal cancers.

Abstract:

:Olfactomedin 4 (OLFM4) is a member of olfactomedin domain-containing protein family. Human OLFM4 is preferentially expressed in the gastrointestinal tract (stomach, small intestine and colon), prostate, and bone marrow. Recent studies demonstrate that OLFM4 is involved in the establishment and/or development of some types of malignancies, especially in gastrointestinal cancers. Induction of OLFM4 in cancer cells has a novel antiapoptotic action and promotes proliferation of cancer cells. OLFM4 regulates cell cycle and promotes S phase transition in proliferation of cancer cells. In addition, OLFM4 is associated with cancer adhesion and metastasis. In this minireview, we mainly focus on the OLFM4 expression and its biological significances in tumor differentiation and progression as well as the contributions of OLFM4 to tumorigenesis.

journal_name

Neoplasma

journal_title

Neoplasma

authors

Yu L,Wang L,Chen S

doi

10.4149/neo_2011_01_9

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

9-13

issue

1

eissn

0028-2685

issn

1338-4317

journal_volume

58

pub_type

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