Inhibitory effect of human urinary extract on the growth of DMBA-induced mammary tumors in Holtzman rat.

Abstract:

:The effect of a crude protein fraction from human urine having gonadotropin inhibitory activity (GGIM) was observed on the growth of 7,12-dimethylbenz(a)anthracene induced mammary tumors in Holtzman rat. Results show that while in 12 out 13 tumors, tumor growth was retarded/regressed following 2--4 weeks of CGIM treatment, tumor growth in control rats was unabated. However, no positive correlation with hormone dependency and tumor regression could be established. Further, this crude anti LH material was found to be non-toxic to tumor cells in vitro.

journal_name

Neoplasma

journal_title

Neoplasma

authors

Sarkar S,Shah PN,Bagli NP

subject

Has Abstract

pub_date

1981-01-01 00:00:00

pages

457-61

issue

4

eissn

0028-2685

issn

1338-4317

journal_volume

28

pub_type

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