Combined radioprotective effect of Broncho-Vaxom and WR-2721 on hemopoiesis and circulating blood cells.

abstract：:The mol LD50 values were correlated with Hammett sigma constants in terms of the Hansen empiric equation 6 for para substituted derivatives of 1-phenyl-3-methyltriazene. Good agreement was achieved and the line slope of the correlation, 0.3, is the same as that found during an identical experiment with derivatives of ...

journal_title：Neoplasma

authors： Matrka M,Rambousek V,Zvĕrina V

更新日期：1978-01-01 00:00:00

abstract：:Glial fibrillary acidic protein (GFAP), vimentin (Vi) and cytokeratin (CK) intermediate filament (IF) proteins were studied in glioblastoma cell line GL-15. The immunofluorescence staining revealed strong positive staining for vimentin in all cultured cells. Approximately 20% of analyzed cells showed strong and 50% mo...

journal_title：Neoplasma

authors： Perzelcová A,Máciková,Tardy M,Mráz P,Steno J,Bízik I

更新日期：2000-01-01 00:00:00

abstract：:In transplanted mice, the P388 tumor grew better in castrated than in non castrated (NC) mice. The proportion of CD8+ in the blood was more numerous in NC mice. The T cell subsets (CD4+ and CD8+) were also high in the mice with small tumor tissue (<10 mg). The correlation observed between the tumor weight and T cell s...

journal_title：Neoplasma

authors： Aboudkhil S,Henry L,Zaid A,Bureau JP

更新日期：2005-01-01 00:00:00

abstract：:Genetic testing based on next-generation sequencing (NGS) analysis has recently been used to diagnose hereditary diseases. In this study, we explored the usefulness of our custom amplicon panel that targeted 23 genes related to hereditary tumors given in the American College of Medical Genetics and Genomics recommenda...

journal_title：Neoplasma

authors： Shinriki S,Maeshiro M,Shimamura K,Kawashima J,Araki E,Ibusuki M,Yamamoto Y,Iwase H,Miyamoto Y,Baba H,Yamaguchi M,Matsui H

更新日期：2020-07-01 00:00:00

abstract：:Factors influencing circulating miRNA as a diagnostic marker of hepatocellular carcinoma (HCC) are still unknown. We used two kits to extract total RNA of 90 paired serum and plasma samples of volunteers in different statuses including healthy, hepatitis, cirrhosis and HCC. U6, miR-183 and cel-miR-39 expression levels...

journal_title：Neoplasma

authors： Wang Y,Liang Z,Gao Y,Zhai D,Rao Q,Shi W,Yang B,Jing L,Guo H,Liu T,Liu J,DU Z

更新日期：2015-01-01 00:00:00

abstract：UNLABELLED:The current study aimed to evaluate the efficacy of sorafenib-based combined therapy against hepatocellular carcinoma (HCC). HepG2 cells were exposed to sorafenib, irinotecan, and oxaliplatin and then subjected to MTT assay to determine chemosensitivity. Flow cytometry was used to examine cell cycle distribu...

journal_title：Neoplasma

authors： Wang Z,Zhao Z,Wu T,Song L,Zhang Y

更新日期：2015-01-01 00:00:00

abstract：:Loss of heterozygosity (LOH) has been shown to be an important prognostic factor in a variety of malignant neoplasm's. Cervical cancer develops as result of multiple genetic alterations. The aim of this study was to analyze presence of LOH in cervical cancer and to identify the correlation between LOH and survival and...

journal_title：Neoplasma

authors： Kozlowski L,Filipowski T,Rucinska M,Pepinski W,Janica J,Skawronska M,Poznanski J,Wojtukiewicz MZ

更新日期：2006-01-01 00:00:00

abstract：:Changes in distribution properties of T lymphocytes from lymphoid organs of normal rats 3H-uridine labeled in vitro and i. v. injected to tumor-bearing recipients were studied at different stages of tumor growth and rejection. Comparisons were made with T cell migration from normal donors to syngeneic recipients. A te...

journal_title：Neoplasma

authors： Klobusická M,Koníková E

更新日期：1982-01-01 00:00:00

abstract：:Oxaliplatin is commonly used in managing malignancy, including colorectal cancer. While treatment often fails due to decreased drug sensitivity, the mechanisms involved are not clear. In this study, we investigate how exosomal miR-19b participates in oxaliplatin sensitivity and then prove that miR-19b down-regulates o...

journal_title：Neoplasma

authors： Gu YY,Yu J,Zhang JF,Wang C

更新日期：2019-01-15 00:00:00

abstract：:Activity of chromatin-bound protease of rat liver and Morris hepatoma 7777 was studied. Proteolytic enzyme was copurified with histones during extraction of chromatin with 0.25 M HCl. Total histone was fractionated by Oliver's et al. method. Histone fractions were incubated in 0.01 M Tris-HCl buffer (pH 7.6) at 37 deg...

journal_title：Neoplasma

authors： Lipińska A,Krawczyk Z,Krajewska W,Kłyszejko-Stefanowicz L,Chorazy M

更新日期：1980-01-01 00:00:00

abstract：:On the basis of the author's own results and literary data emphasis is laid on the significance of lymphography for confirming or establishing a diagnosis, for determining the extent of a lesion and for proper considerations on indications for surgical treatment. Relymphography following a surgical intervention is cap...

journal_title：Neoplasma

authors： Kutarna A

更新日期：1975-01-01 00:00:00

abstract：:A modification of the "skin window" method is proposed for investigation of delayed hypersensitivity in patients with tumors. The principle of the modified method consists in an antigen injection into the site of lesion. Patients with tumors showed a strikingly lowered lymphoid cells and eosinophilic and basophilic gr...

journal_title：Neoplasma

authors： Jansa P,Jorda V,Sternberský J

更新日期：1976-01-01 00:00:00

abstract：:Breast cancer is one of the leading causes of cancer death in women. The Notch family of proteins plays crucial roles in determining cell fates such as proliferation, differentiation and apoptosis. A role for Notch signaling in human breast cancer has been suggested by the development of adenocarcinomas in the murine ...

journal_title：Neoplasma

authors： Zang S,Ji Ch,Qu X,Dong X,Ma D,Ye J,Ma R,Dai J,Guo D

更新日期：2007-01-01 00:00:00

abstract：:During the decade 1968-1977 a total of 1488 cases of neoplasms were registered in Slovakia in children aged 0-14 years giving an average annual age-specific rate of 120.7 per million. Tumors prevailed in boys with 131.2 in comparison with girls showing 109.7 incidence rate/10(6). The most common malignancies were leuk...

journal_title：Neoplasma

authors： Plesko I,Somogyi J,Dimitrova E

更新日期：1983-01-01 00:00:00

abstract：:In our earlier report on circulating immune complexes (CIC) from sera of patients with Hodgkin's disease (HD), we demonstrated disease-associated increase in the intensity of a 40kD (pl 5.6) polypeptide in the CIC. In extension of these investigations, we now report that the 40kD moiety exists in CIC as a complex with...

journal_title：Neoplasma

authors： Nerurkar AV,Advani SH,Gothoskar BP

更新日期：1993-01-01 00:00:00

abstract：:Relation between the electronic structure of aromatic compounds and their carcinogenic activity has been correlated. Hypotheses of K, L regions have been employed. Possibilities of better theoretical description of carcinogenic activity have been examined by including the effect of medium and by using a more exact qua...

journal_title：Neoplasma

authors： Miertus S

更新日期：1979-01-01 00:00:00

abstract：:16 colon cancer patients in the second clinical stage (according to the TNM classification), aged 34 to 71 years were studied before and 14 days after radical surgery. The in vitro cell-mediated immunity was evaluated using the rosette-forming test and blastogenic reactivity of blood lymphocytes to PHA. The percentage...

journal_title：Neoplasma

authors： Markova R,Argirova R,Boeva M

更新日期：1980-01-01 00:00:00

abstract：:Sera from 51 melanoma patients and from 55 healthy donors were examined for the presence of immune complexes (ICs) by the EA-rosette forming cell inhibition assay. Using a cut-off point of 5% rosette inhibition, ICs were found in 144 out of 213 sera from patients with melanoma (67.6%) and in 11 out of 55 control subje...

journal_title：Neoplasma

authors： Sztaba-Kania M,Jassem J,Piskorzyńska M,Kondrat W

更新日期：1981-01-01 00:00:00

abstract：:The immunogenic properties of MC-induced and not metastasizing tumors were tested in inbred Wistar and August strains by the aid of lymphocyte stimulation in syngeneic draining lymph nodes in the comparison with the opposite ones. The lymphocyte stimulation was estimated in vitro by the spontaneous incorporation of 3H...

journal_title：Neoplasma

authors： Ryzewska AG,Rybicka M,Kania A,Dabrowski M

更新日期：1980-01-01 00:00:00

abstract：:Polymorphisms in tobacco carcinogen metabolizing enzymes may generate interindividual variations towards the risk of developing prostate cancer. One of these enzymes is microsomal epoxide hydrolase (EPHX1) which metabolizes polycyclic aromatic hydrocarbons, or PAH, carcinogens found in cigarette smoke. The activity of...

journal_title：Neoplasma

authors： Sivonova MK,Dobrota D,Matakova T,Dusenka R,Grobarcikova S,Habala V,Salagovic J,Tajtakova M,Pidanicova A,Valansky L,Lachvacs L,Kliment J Jr,Nagy V,Kliment J

更新日期：2012-01-01 00:00:00

abstract：:An in vitro system of colony forming cell inhibition was used for evaluation of 3-oxauracil (2,3-dihydro-1,3-6H-oxazine-2,6-dione) effectivity against bone marrow cells from 18 leukemic patients. The highest inhibitive activity of the 3-oxauracil was found in cases of acute lymphoblastic leukemia, comparing with bone ...

journal_title：Neoplasma

authors： Reiner P,Mardiak J,Reinerová M,Ujházy V

更新日期：1981-01-01 00:00:00

abstract：:Metadherin (MTDH) is an oncoprotein and is expressed at high levels in a wide variety of human carcinomas, which represents an important genetic determinant and regulates multiple events in tumorigenesis. MTDH promotes breast cancer cell proliferation and tumorigenesis through the activation of numerous signaling path...

journal_title：Neoplasma

authors： Chen X,Li XY,Long M,Wang X,Gao ZW,Cui Y,Ren J,Zhang Z,Liu C,Dong K,Zhang H

更新日期：2018-01-01 00:00:00

abstract：:The effects of first-line chemotherapy on overall survival (OS) might be confounded by subsequent therapies in patients with non-small cell lung cancer (NSCLC). We examined whether progression-free survival (PFS), post-progression survival (PPS), or tumor response could be valid surrogate endpoints for OS after first-...

journal_title：Neoplasma

authors： Imai H,Takahashi T,Mori K,Ono A,Akamatsu H,Shukuya T,Taira T,Kenmotsu H,Naito T,Murakami H,Endo M,Nakajima T,Yamamoto N

更新日期：2014-01-01 00:00:00

abstract：:The mannose 6-phosphate/insulin-like growth factor 2 receptor (CD222, M6P/IGF2R) is a multifunctional transmembrane type I receptor, mostly localized intracellularly, less on the surface of all types of mammalian cells. It is known both to transport lysosomal enzymes through their mannose 6-phosphate moieties and to i...

journal_title：Neoplasma

authors： Vicikova K,Petrovcikova E,Manka P,Drach J,Stockinger H,Leksa V

更新日期：2018-09-19 00:00:00

abstract：:This study aimed to identify the oncogenes associated with lung cancer based on the mRNA and single nucleotide polymorphism (SNP) profile data. The mRNA expression profile data of GSE43458 (80 cancer and 30 normal samples) and SNP profile data of GSE33355 (61 pairs of lung cancer samples and control samples) were down...

journal_title：Neoplasma

authors： Wang Y,Mei Q,Ai YQ,Li RQ,Chang L,Li YF,Xia YX,Li WH,Chen Y

更新日期：2015-01-01 00:00:00

abstract：:Cytokinesis-block micronucleus assay (CB-MNA) was applied for comparison of radiation sensitivity of 25 human malignant melanomas in primary culture. Cells obtained from tumor specimens were irradiated (0-4.Gy) on dishes, incubated with cytochalasin B (2 micrograms/ml) to block cytokinesis, stained in situ and micronu...

journal_title：Neoplasma

authors： Wideł M,Dobrut M,Maka B,Lubecka B,Pluciennik A

更新日期：1997-01-01 00:00:00

abstract：:Ovarian cancer is the most lethal gynecologic malignancy in women with an increasing number of cases worldwide. Chemoresistance is the main obstacle for ovarian cancer treatment during clinical therapy. Previous studies found that programmed cell death 1 ligand 1 (PD-L1) was associated with chemoresistance of cancer. ...

journal_title：Neoplasma

authors： Zuo Y,Zheng W,Liu J,Tang Q,Wang SS,Yang XS

更新日期：2020-01-01 00:00:00

abstract：:Analysis of literary data and the author's findings have shown that the transplacental action of most of the compounds tested in experiments on rats manifested itself by a neurotropic carcinogenic effect. A marked neurotropism in transplacental carcinogenesis in rats is characteristic even for such drugs (e.g. dimethy...

journal_title：Neoplasma

authors： Alexandrov VA

更新日期：1976-01-01 00:00:00

abstract：:With the use of 14C-arginine it is shown that among the ascitic fluid proteins of Ehrlich tumor there appear basic proteins rich in arginine with the content of amino acid about 14%. The amount of these proteins is about 3%. They exhibit great similarity in respect to arginine content, electrophoretic mobility to the ...

journal_title：Neoplasma

authors： Farbiszewski R,Zdrodowska J,Kilczewska D

更新日期：1981-01-01 00:00:00

abstract：:Surgical specimens from two patients with simultaneously occurring ovarian and endometrial endometrioid carcinoma were studied by flow cytometry (FCM) and routine histological examination. Tissue derived from the uterine and the ovarian lesion showed similar FCM curves in each case. The information obtained from FCM w...

journal_title：Neoplasma

authors： Vassilev NB,Christov KT,Raychev RD

更新日期：1986-01-01 00:00:00