当前位置： SCI文献检索 > NEOPLASMA期刊下所有文献 > Expression of CD147 in advanced non-small cell lung cancer correlated with cisplatin-based chemotherapy resistance.

Expression of CD147 in advanced non-small cell lung cancer correlated with cisplatin-based chemotherapy resistance.

Abstract：

:CD147, a widely expressed cell surface glycoprotein in cancer, is associated with tumor invasiveness and chemotherapy resistance. Recently, CD147 is also regarded as a potential therapeutic target for cancer therapy. The aim of the study was to investigate CD147 expression in non-small cell lung cancer (NSCLC), and evaluate its correlation with cisplatin-based chemotherapy resistance. In this study, we examined immunohistochemically the expression of CD147 in 118 advanced NSCLC cases treated with cisplatin-based chemotherapy, and then the association of CD147 expression with clinicopathological characteristics was analyzed. Furthermore, RNA interference approach was used to silence CD147 expression in a cisplatin-resistant human lung cancer cell line A549/DDP, and the inhibition effect of cisplatin on tumor cells was assayed by MTT. In the overall series, positive CD147 expression was observed in 101/118 (85.6%) cases. A membranous CD147 pattern was identified in 76/101 (75.2%) of CD147 positive tumors. CD147 membranous expression,but not the overall CD147 expression, was associated with poor response to cisplatin-based chemotherapies and a poor prognosis in advanced NSCLC patients. In vitro results showed that silencing CD147 increased the proliferation inhibitory effect of cisplatin to A549/DDP cells. In conclusion, our study indicated that membranous CD147 expression is a predictive factor of the response to cisplatin-based chemotherapies, and the use of CD147-targeted therapeutic adjuvants might be considered in the treatment of advanced NSCLC patients.

journal_name

Neoplasma

journal_title

Neoplasma

authors

Zeng HZ,Qu YQ,Liang AB,Deng AM,Zhang WJ,Xiu B,Wang H,Wang H

doi

10.4149/neo_2011_05_449

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

449-54

issue

5

eissn

0028-2685

issn

1338-4317

journal_volume

58

pub_type

杂志文章

相关文献

NEOPLASMA文献大全
  • Effect of testosterone on growth of P388 leukemia cell line in vivo and in vitro. Distribution of peripheral blood T lymphocytes and cell cycle progression.

    abstract：:In transplanted mice, the P388 tumor grew better in castrated than in non castrated (NC) mice. The proportion of CD8+ in the blood was more numerous in NC mice. The T cell subsets (CD4+ and CD8+) were also high in the mice with small tumor tissue (<10 mg). The correlation observed between the tumor weight and T cell s...

    journal_title：Neoplasma

    pub_type： 杂志文章

    doi：

    authors： Aboudkhil S,Henry L,Zaid A,Bureau JP

    更新日期：2005-01-01 00:00:00

  • Cytology of delayed hypersensitivity reaction in patients with malignant tumors.

    abstract：:A modification of the "skin window" method is proposed for investigation of delayed hypersensitivity in patients with tumors. The principle of the modified method consists in an antigen injection into the site of lesion. Patients with tumors showed a strikingly lowered lymphoid cells and eosinophilic and basophilic gr...

    journal_title：Neoplasma

    pub_type： 杂志文章

    doi：

    authors： Jansa P,Jorda V,Sternberský J

    更新日期：1976-01-01 00:00:00

  • In vitro and in vivo studies of antitumor effects of the recombinant immunotoxin MSH-PE38KDEL on melanoma.

    abstract：:MSH-PE38KDEL is a chimeric molecule composed of MSH, and fused to a truncated mutant form of Pseudomonas exotoxin (PE38KDEL). Our study aims to evaluate the specific cytotoxicity of recombinant immunotoxin MSH-PE38KDEL on melanoma cells A875 and B16 in vitro, as well as its inhibition of metastatic melanoma in vivo. M...

    journal_title：Neoplasma

    pub_type： 杂志文章

    doi：10.4149/neo_2014_048

    authors： Hui Q,Ma J,Song J,Liu Z,Ren H,Jiang W,Wang Y,Xu Y,Guo D,Zhang X,Lu S

    更新日期：2014-01-01 00:00:00

  • The inhibitory effect of human embryonic germ cells on ovarian cancer.

    abstract：:Cancer cells share numerous characteristics with pluripotent stem cells which develop normally, contributing to the tumor cell plasticity. So we investigated the effect of human embryonic germ cells (hEGCs) on SKOV3 cells. We examined the efficacy of hEGCs through coculturing SKOV3 with hEGCs, detecting tunel apoptosi...

    journal_title：Neoplasma

    pub_type： 杂志文章

    doi：10.4149/neo_2009_01_13

    authors： Song X,Kong B,Li D,Yang Q

    更新日期：2009-01-01 00:00:00

  • Retrospective analysis of efficacy of trastuzumab in adjuvant treatment of HER 2 positive early breast cancer - single institution experience.

    abstract：:Addition of trastuzumab to chemotherapy is the cornerstone of adjuvant treatment of early HER2 positive breast cancer. Clinical trials and metaanalyses of adjuvant trastuzumab have shown significant reduction in risk of recurrence and death. Nevertheless, the real magnitude of the effect of any drug must be reevaluate...

    journal_title：Neoplasma

    pub_type： 杂志文章

    doi：10.4149/neo_2016_513

    authors： Ban M,Viculin J,Tomic S,Capkun V,Strikic A,Mise BP,Utrobicic I,Vrdoljak E

    更新日期：2016-01-01 00:00:00

  • Identification of lung cancer oncogenes based on the mRNA expression and single nucleotide polymorphism profile data.

    abstract：:This study aimed to identify the oncogenes associated with lung cancer based on the mRNA and single nucleotide polymorphism (SNP) profile data. The mRNA expression profile data of GSE43458 (80 cancer and 30 normal samples) and SNP profile data of GSE33355 (61 pairs of lung cancer samples and control samples) were down...

    journal_title：Neoplasma

    pub_type： 杂志文章

    doi：10.4149/neo_2015_117

    authors： Wang Y,Mei Q,Ai YQ,Li RQ,Chang L,Li YF,Xia YX,Li WH,Chen Y

    更新日期：2015-01-01 00:00:00

  • Differential effect of protein kinase inhibitors (staurosporine and CGP 41,251) on TPA-induced homotypic aggregation and cell surface adhesion antigen expression in human monoblastoid cell line U-937.

    abstract：:The phorbolester (TPA)-induced homotypic aggregation of human monoblastoid U-937 cells was completely abolished by staurosporine, but not by a new selective protein kinase C inhibitor, benzoylated staurosporine derivative CGP 41,251, a compound with known anti-tumor and drug resistance modulating activity. Staurospori...

    journal_title：Neoplasma

    pub_type： 杂志文章

    doi：

    authors： Sedlák J,Sulíková M,Hunáková L,Chorváth B

    更新日期：1995-01-01 00:00:00

  • PK11195, an isoquinoline carboxamide ligand of the mitochondrial benzodiazepine receptor, increased drug uptake and facilitated drug-induced apoptosis in human multidrug-resistant leukemia cells in vitro.

    abstract：:The isoquinoline peripheral benzodiazepine receptor ligand PK11195 increased drug (daunomycin)- and fluorochrome (calcein-AM) uptake and induced apoptosis detected by flow cytometry (FCM) technique, DNA electrophoretic analysis and poly(ADP-ribose) polymerase (PARP) cleavage in human multidrug-resistant myeloid leukem...

    journal_title：Neoplasma

    pub_type： 杂志文章

    doi：

    authors： Jakubikova J,Duraj J,Hunakova L,Chorvath B,Sedlak J

    更新日期：2002-01-01 00:00:00

  • Interactions between the growth effects of a kidney epithelial cell growth inhibitor and extracellular concentrations of cyclic nucleotides.

    abstract：:The effect of dibutyryl cyclic nucleotides, dbcAMP and dbcGMP, on the growth of BSC-1 cells has been studied in the presence and absence of kidney epithelial cell growth inhibitor. The growth response of the cells was dependent on concentrations of the dibutyryl cyclic nucleotides and on the presence or absence of ser...

    journal_title：Neoplasma

    pub_type： 杂志文章

    doi：

    authors： Fremuth F,Holley RW,Baldwin JH

    更新日期：1982-01-01 00:00:00

  • Chromosomal anomalies in children treated for cancer.

    abstract：:Cytogenetic studies were carried out in peripheral blood lymphocytes of 31 children with cancer (12 retinoblastomas, 9 non-Hodgkin's lymphomas, 7 neuroblastomas and 3 Wilms' tumors) with the purpose of investigating the prevalence and persistence of chromosomal aberrations before onset of antineoplastic treatment and ...

    journal_title：Neoplasma

    pub_type： 杂志文章

    doi：

    authors： García J,Ruisánchez N,Longchong M,Valdés M,Puig M,Menéndez J,Alert J,Ramos S

    更新日期：1986-01-01 00:00:00

  • Flow cytometry in brain tumors. I. Ploidy abnormalities.

    abstract：:Flow cytometry (FCM) was introduced for estimation of DNA content in 75 brain tumors. Among these astrocytomas (38 cases) and meningiomas (16 cases) predominated. Astrocytomas were histologically subdivided into 3 groups of malignancy grade. Aneuploid cell populations were found in 1 out of 4 cases of astrocytoma grad...

    journal_title：Neoplasma

    pub_type： 杂志文章

    doi：

    authors： Christov K,Zapryanov Z

    更新日期：1986-01-01 00:00:00

  • Expression of putative stem marker nestin and CD133 in advanced serous ovarian cancer.

    abstract：:It is hypothesized that "cancer stem cells" are responsible for the resistance to chemotherapy of cancer cells in ovarian cancers. The objective of the studies was to explore if the stem cell biomarkers could be used to predict the tumor chemotherapy-resistance in serous ovarian cancer patients. Expression of two puta...

    journal_title：Neoplasma

    pub_type： 杂志文章

    doi：10.4149/neo_2012_040

    authors： Qin Q,Sun Y,Fei M,Zhang J,Jia Y,Gu M,Xia R,Chen S,Deng A

    更新日期：2012-01-01 00:00:00

  • Some data concerning immune processes in concomitant tumor immunity experimental models. Comparative in vivo and in vitro investigations II. In vitro experiments.

    abstract：:The humoral and cellular immune status of C57BL/6 male mice and "R" male rats bearing MC-induced sarcomas were investigated in vitro, using 51Cr-releasing and mixed hemadsorption assays. Analysis was performed on mice subjected to concomitant tumor immunity (CTI) model experiments or bearing primary tumors of differen...

    journal_title：Neoplasma

    pub_type： 杂志文章

    doi：

    authors： Donovan G,Popp I,Badea E,Bologa L

    更新日期：1977-01-01 00:00:00

  • Upregulated circZMIZ1 promotes the proliferation of prostate cancer cells and is a valuable marker in plasma.

    abstract：:Increasing evidences have proved that circular RNAs (circRNAs), identified as a specific kind of non-coding RNAs, play a potential critical role in tumorigenesis including prostate cancer. However, the function of circRNAs in human prostate cancer remain largely unknown. In this study, we demonstrated that the express...

    journal_title：Neoplasma

    pub_type： 杂志文章

    doi：10.4149/neo_2019_190213N116

    authors： Jiang H,Lv DJ,Song XL,Wang C,Yu YZ,Zhao SC

    更新日期：2020-01-01 00:00:00

  • TRIM31 promotes proliferation, invasion and migration of glioma cells through Akt signaling pathway.

    abstract：:This study is intended to investigate the role of Tripartite Motif (TRIM) 31 in glioma. Immunohistochemistry and western blot analysis showed that TRIM31 was overexpressed in high-grade glioma tissues. Univariate survival analysis indicated that high expression of TRIM31 was related to short survival time of glioma pa...

    journal_title：Neoplasma

    pub_type： 杂志文章

    doi：10.4149/neo_2019_190106N21

    authors： Shi G,Lv C,Yang Z,Qin T,Sun L,Pan P,Wang D

    更新日期：2019-09-01 00:00:00

  • 14C-arginine-rich basic proteins in ascitic fluid of Ehrlich tumor.

    abstract：:With the use of 14C-arginine it is shown that among the ascitic fluid proteins of Ehrlich tumor there appear basic proteins rich in arginine with the content of amino acid about 14%. The amount of these proteins is about 3%. They exhibit great similarity in respect to arginine content, electrophoretic mobility to the ...

    journal_title：Neoplasma

    pub_type： 杂志文章

    doi：

    authors： Farbiszewski R,Zdrodowska J,Kilczewska D

    更新日期：1981-01-01 00:00:00

  • Expression of the P65 gene in gastric cancer and in tissues with or without Helicobacter pylori infection.

    abstract：:A 65-kDa tumor-associated protein (P65) is a potential non- specific tumor marker expressed by many types of tumor cells. Our recent studies indicate that P65 gene expression is connected with poor prognosis for the patients with colorectal cancer. In the present study P65 gene expression was determined by means of RT...

    journal_title：Neoplasma

    pub_type： 杂志文章

    doi：

    authors： Balcerczak E,Jankowski T,Becht A,Balcerczak M,Janiuk R,Jesionek-Kupnicka D,Sztompka J,Mirowski M

    更新日期：2005-01-01 00:00:00

  • Immunogenicity of methylcholanthrene-induced tumors tested by draining lymph node assay in syngeneic rats.

    abstract：:The immunogenic properties of MC-induced and not metastasizing tumors were tested in inbred Wistar and August strains by the aid of lymphocyte stimulation in syngeneic draining lymph nodes in the comparison with the opposite ones. The lymphocyte stimulation was estimated in vitro by the spontaneous incorporation of 3H...

    journal_title：Neoplasma

    pub_type： 杂志文章

    doi：

    authors： Ryzewska AG,Rybicka M,Kania A,Dabrowski M

    更新日期：1980-01-01 00:00:00

  • Tumoricidal properties of rat peritoneal macrophages activated with various activators depend on nitrogen oxid synthesis.

    abstract：:Cytolytic activity of mineral oil elicited rat peritoneal macrophages activated by lipopolysaccharide (LPS) and/or rIFN-gamma, rIL-2, Zymosan and PMA (4-beta-phorbol-12-beta-myristate 13-alpha-acetate) was detected in the presence of various concentrations of L-arginine. This paralleled the NO2- production in the pres...

    journal_title：Neoplasma

    pub_type： 杂志文章

    doi：

    authors： Kusenda J,Kalafut F,Klobusická M,Novotná L

    更新日期：1992-01-01 00:00:00

  • Mucopolysaccharides in gastric cancer.

    abstract：:The histochemical properties of mucus in 48 diffuse type gastric carcinomas and in 46 intestinal type gastric cancers were investigated. In the diffuse type there was a prevalence of intracellular secretion of mucopolysaccharides with a significantly larger portion of sulfated mucopolysaccharides. Acid mucopolysacchar...

    journal_title：Neoplasma

    pub_type： 杂志文章

    doi：

    authors： Tichá V,Jansa P,Tichý M

    更新日期：1988-01-01 00:00:00

  • TRAV gene expression in PBMCs and TILs in patients with breast cancer analyzed by a DNA melting curve (FQ-PCR) technique for TCR α chain CDR3 spectratyping.

    abstract：PURPOSE:To explore the expression of the TRAV gene in peripheral blood mononuclear cells (PBMCs) and in tumor-infiltrating lymphocytes (TILs) in the patients with breast cancer using a DNA melting curve (FQ-PCR) technique for T cell receptor (TCR) alpha chain CDR3 spectratyping. Peripheral blood samples and tissue samp...

    journal_title：Neoplasma

    pub_type： 杂志文章

    doi：10.4149/neo_2012_088

    authors： He XY,Yang WM,Tang WT,Ma R,Sun YP,Wang P,Yao XS

    更新日期：2012-01-01 00:00:00

  • Quadruple cancer, including triple cancers in the head and neck region.

    abstract：:Multiple primary tumors are not rare: they are encountered in 3-5% of malignant tumors. They are particularly frequent in the head and neck [20]. They are most often met with secondary malignant tumors; triple tumors occur in only 0.5%, quadruple tumors in 0.3% of malignant tumors. The possibility of developing a seco...

    journal_title：Neoplasma

    pub_type： 杂志文章

    doi：

    authors： Németh Z,Czigner J,Iván L,Ujpál M,Barabás J,Szabó G

    更新日期：2002-01-01 00:00:00

  • Expression profile of long noncoding RNAs in human papillary thyroid carcinoma.

    abstract：:Long non-coding RNAs (lncRNAs) are strongly associated with cancer biology. The objective of this study is to investigate the expression profile of lncRNAs in human papillary thyroid carcinoma (PTC), and to understand the biological role of lncRNAs and their involvement in PTC oncogenesis. The lncRNAs and messenger RN...

    journal_title：Neoplasma

    pub_type： 杂志文章

    doi：10.4149/neo_2018_180625N414

    authors： Cao Y,Shi C,Li J,Liang Y,Qiu J,Yuan L,Yong Z,Zhang DX,Shi GQ

    更新日期：2019-03-05 00:00:00

  • Mitochondrial ATPase of Zajdela hepatoma. V. Mitochondria of Zajdela hepatoma contain membrane sectors of ATPase complex unassociated with F1.

    abstract：:Relative content of membrane sectors of ATPase complex in rat liver and Zajdela hepatoma mitochondria and the ability of mitochondrial membrane of the two sources to bind isolated soluble (F1) ATPase were examined. Approximately equal concentrations of oligomycin were required for 50% inhibition of ATPase activity in ...

    journal_title：Neoplasma

    pub_type： 杂志文章

    doi：

    authors： Kuzela S,Kolarov J,Krempaský V,Luciaková K,Ujházy V

    更新日期：1978-01-01 00:00:00

  • Inhibition of miR-103a-3p suppresses the proliferation in oral squamous cell carcinoma cells via targeting RCAN1.

    abstract：:Oral cancer is one of the common cancers worldwide, among which over 90% are oral squamous cell carcinomas (OSCC). MicroRNAs act as critical regulators of cancer development and progression. MiR-103a-3p has been reported to be upregulated in OSCC patients and closely correlated to poor prognosis, yet its roles in the ...

    journal_title：Neoplasma

    pub_type： 杂志文章

    doi：10.4149/neo_2020_190430N382

    authors： Zhang G,Chen Z,Zhang Y,Li T,Bao Y,Zhang S

    更新日期：2020-05-01 00:00:00

  • Heterochromatin condensation in central and peripheral nuclear regions of maturing lymphocytes in the peripheral blood of patients suffering from B chronic lymphocytic leukemia - a cytochemical study.

    abstract：:The present study was undertaken to provide complementary information on heterochromatin condensation in central and peripheral nuclear regions during maturation of human leukemic lymphocytes using simple image processing and DNA image densitometry at the single cell level. Such approach indicated that the heterochrom...

    journal_title：Neoplasma

    pub_type： 杂志文章

    doi：10.4149/neo_2011_06_476

    authors： Smetana K,Karhan J,Trneny M

    更新日期：2011-01-01 00:00:00

  • Light and electron microscopy of mouse lymphosarcoma LS/BL cells during the first hour after irradiation with x-rays.

    abstract：:Mouse lymphosarcoma LS/BL cells growing in tissue culture were irradiated with 100, 316 and 1000 R respectively and fixed 5, 15 or 60 minutes later. Semithin sections were studied under a light and ultrathin under an electron microscopes. Under the light microscope, differences between the morphology of individual nuc...

    journal_title：Neoplasma

    pub_type： 杂志文章

    doi：

    authors： Tkadlecek L,Karpfel Z,Cibulka M,Viklická S,Spurná V

    更新日期：1975-01-01 00:00:00

  • Overexpression of AEG-1 in renal cell carcinoma and its correlation with tumor nuclear grade and progression.

    abstract：UNLABELLED:The study was aimed at detecting the expression of a newly found oncogene, astrocyte elevated gene-1 (AEG-1), in renal cell carcinoma (RCC) and its correlation with histopathologic features and the survival of patients. Real-time reverse transcription-PCR and Western blot showed markedly higher expression of...

    journal_title：Neoplasma

    pub_type： 杂志文章

    doi：10.4149/neo_2010_06_522

    authors： Chen W,Ke Z,Shi H,Yang S,Wang L

    更新日期：2010-01-01 00:00:00

  • Fine needle aspiration cytology of benign breast disease. Markers of apoptosis and proliferation.

    abstract：:Aim of the study was to compare the fine needle aspiration cytology findings of benign breast lesions with incidence of proliferation markers and apoptosis. This study included 37 patients with palpable breast lumps, referred for USG guided FNA. FNAC were prospectively classified as C2-benign, C4-suspicious of maligna...

    journal_title：Neoplasma

    pub_type： 杂志文章

    doi：

    authors： Swiatecka J,Laudański P,Dziecioł J

    更新日期：2004-01-01 00:00:00

  • On the so-called MAC (Maximal Allowable Concentrations) for carcinogenic hydrocarbons.

    abstract：:The paper deals with some results of work done in the USSR to establish maximal allowable doses (MAC) for the carcinogenic hydrocarbon benza(a)pyrene in human environment. At the same time it is a brief review of some discussions on this item which took place in USSR and on the international level. ...

    journal_title：Neoplasma

    pub_type： 杂志文章

    doi：

    authors： Shabad LM

    更新日期：1975-01-01 00:00:00