Abstract：
:Increasing evidences have proved that circular RNAs (circRNAs), identified as a specific kind of non-coding RNAs, play a potential critical role in tumorigenesis including prostate cancer. However, the function of circRNAs in human prostate cancer remain largely unknown. In this study, we demonstrated that the expression of circZMIZ1 was higher in plasma of human prostate cancer than the paired benign prostatic hyperplasia (BPH) patients' plasma. Moreover, in cultured prostate cancer cells, knockdown of circZMIZ1 inhibited cell proliferation and caused cell cycle arrest at G1. Mechanistically, we also showed that circZMIZ1 could increase the expression of androgen receptor (AR) and androgen receptor splice variant 7 (AR-V7), which may be partly contributed to the occurrence and development of prostate cancer. In conclusion, these results revealed that circZMIZ1 might serve as a novel biomarker and a treatment target for prostate cancer treatment.
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Jiang H,Lv DJ,Song XL,Wang C,Yu YZ,Zhao SCdoi
10.4149/neo_2019_190213N116subject
Has Abstractpub_date
2020-01-01 00:00:00pages
68-77issue
1eissn
0028-2685issn
1338-4317pii
190213N116journal_volume
67pub_type
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