Abstract：
:The aim of the presented study was to evaluate the long-term outcome of breast-conserving surgery and radiation for the treatment of ductal carcinoma in situ (DCIS) and the role of the radiation boost to the tumor bed. The files of 75 women with DCIS treated by breast-conserving surgery followed by definitive radiation from 1988 to 1997 were reviewed for demographic data, prognostic variables, radiation dose, radiation boost, recurrence, and outcome. Total radiation dose was 5000 cGy delivered in 25 fractions. Twenty patients (26.7%) received an additional boost to the tumor bed of 1000 cGy in 5 fractions. Median follow-up time was 81.5 months (range, 22-145). Pearson correlation coefficient and its significance was calculated between the variables. Log rank test was used to analyze differences in local recurrence rates between patients who did or did not receive a boost, and a Cox regression model was fitted to the data to predict recurrence. Ten patients (13%) had local recurrence; one patient showed lymphatic spread. Histopathologic examination revealed DCIS in 6 cases (60%) and invasive duct carcinoma in 4 (40%)(one minimally invasive). The recurrence group included 3 of the 20 patients who received a radiation boost (15%) and 7 of the 55 who did not (12.7%) (p=0.7). Correlation analysis of patient characteristics, prognostic factors, and treatment was significant only between mastitis as the presenting symptom (n=4) and longer time to recurrence (p=0.02). The recurrence rate in the present study was similar to other series of conservative treatment for DCIS of the breast. No additional value was found for the radiation boost. Larger controlled randomized studies are needed to confirm these findings.
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Yerushalmi R,Sulkes A,Mishaeli M,Neumann A,Dinerman M,Sulkes J,Rizel S,Yarom N,Gutman H,Fenig Esubject
Has Abstractpub_date
2006-01-01 00:00:00pages
507-10issue
6eissn
0028-2685issn
1338-4317journal_volume
53pub_type
杂志文章相关文献
NEOPLASMA文献大全abstract：:In contrast to other countries with predominantly white populations, Russian smoking-related lung cancers (LC) are mainly squamous cell carcinomas and approximately half lung adenocarcinomas (AdCa) are not related to tobacco consumption. Given that smoking significantly influences the probability of presence of action...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2018_171225N843
更新日期：2018-11-15 00:00:00
abstract：:Sera from 51 melanoma patients and from 55 healthy donors were examined for the presence of immune complexes (ICs) by the EA-rosette forming cell inhibition assay. Using a cut-off point of 5% rosette inhibition, ICs were found in 144 out of 213 sera from patients with melanoma (67.6%) and in 11 out of 55 control subje...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:Oral cancer is one of the common cancers worldwide, among which over 90% are oral squamous cell carcinomas (OSCC). MicroRNAs act as critical regulators of cancer development and progression. MiR-103a-3p has been reported to be upregulated in OSCC patients and closely correlated to poor prognosis, yet its roles in the ...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2020_190430N382
更新日期：2020-05-01 00:00:00
abstract：:Loss of heterozygosity (LOH) has been shown to be an important prognostic factor in a variety of malignant neoplasm's. Cervical cancer develops as result of multiple genetic alterations. The aim of this study was to analyze presence of LOH in cervical cancer and to identify the correlation between LOH and survival and...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:By the use of the dextran-coated charcoal method the presence of a high-affinity binding site for benzo(a)pyrene in the cytosol from rat liver (R strain) has been demonstrated. This binder was saturable by ligand concentration and by time. Sucrose density gradient analysis after charcoal treatment revealed one major p...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:Von Hippel-Lindau (VHL) disease is an autosomal dominantly inherited cancer predisposition syndrome due to germline mutations in the VHL tumor suppressor gene which is associated with virtually complete penetrance. The VHL syndrome has a highly variable phenotypic expressivity including retinal and CNS haemangioblasto...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：:The authors present results of a preliminary study on the efficiency of the preparation Penberol [VUFB Prague (cis-beta-4-pentoxy-benzoyl-beta-bromoacrylic acid) CHECO protocol number 4] in the ovarian carcinoma of the stage III and IV (FIGO) in which the drug was used after the failure of the first choice chemotherap...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:Metadherin (MTDH) is an oncoprotein and is expressed at high levels in a wide variety of human carcinomas, which represents an important genetic determinant and regulates multiple events in tumorigenesis. MTDH promotes breast cancer cell proliferation and tumorigenesis through the activation of numerous signaling path...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2018_170228N149
更新日期：2018-01-01 00:00:00
abstract：:16 colon cancer patients in the second clinical stage (according to the TNM classification), aged 34 to 71 years were studied before and 14 days after radical surgery. The in vitro cell-mediated immunity was evaluated using the rosette-forming test and blastogenic reactivity of blood lymphocytes to PHA. The percentage...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:The Carr-Zilber strain of Rous sarcoma virus is highly oncogenic for adult monkeys of the species Macaca mulata. In the present study, we examined some characteristics of tumor growth when the tumor either regressed or progressed until it killed its host. We followed the kinetics of antibody formation to antigens code...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:Olfactomedin 4 (OLFM4) is a member of olfactomedin domain-containing protein family. Human OLFM4 is preferentially expressed in the gastrointestinal tract (stomach, small intestine and colon), prostate, and bone marrow. Recent studies demonstrate that OLFM4 is involved in the establishment and/or development of some t...
journal_title：Neoplasma
pub_type： 杂志文章,评审
doi：10.4149/neo_2011_01_9
更新日期：2011-01-01 00:00:00
abstract：:The aim of the study was to evaluate the expression of activated mammalian rapamycin (mTOR) and its downstream effectors, phosphorylated p70 ribosomal protein S6 kinase (p70S6K) and eukaryotic initiation factor 4E-binding protein 1 (4EBP1), in intrahepatic cholangiocarcinomas (ICC), in order to strengthen the rational...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2012_018
更新日期：2012-01-01 00:00:00
abstract：:Transplacental effect of benzo(a)pyrene was studied in organ cultures of embryonic lung tissue explanted from mouse donors injected by the carcinogen. Hyperplastic alteration of epithelium, followed by adenomatous changes were seen in embryonic lung tissue cultures from donor mice injected by benzo(a)pyrene. No altera...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1975-01-01 00:00:00
abstract：:Liver cancer is the sixth most prevalent cancer worldwide and the third leading cause of cancer-related deaths. Adriamycin (ADR) resistance, which often leads to the progression of malignant tumors, is a major treatment obstacle for liver cancer. It has been confirmed that miR-155-5p could reverse drug resistance in h...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2020_200106N17
更新日期：2021-01-01 00:00:00
abstract：:A 10-year old Nigerian boy was admitted to hospital with a history of swelling in the neck, change of voice, dysphagia and dyspnoea of 2 weeks duration. He died on the 2nd day of admission. Autopsy revealed a thymoma infiltrating the thyroid, trachea and neck muscles and transforming the tracheal lumen into a slit lik...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：UNLABELLED:Antiangiogenic drugs are approved for many cancer types for longer than a decade. Furthermore, several antiangiogenic agents are approved for local application in ophthalmology for treatment of macular degeneration, venous retinal occlusion and diabetic retinopathy. Knowing that antiangiogenic agents are act...
journal_title：Neoplasma
pub_type： 杂志文章,评审
doi：
更新日期：2016-01-01 00:00:00
abstract：:MHC class I chain-related molecule A (MICA) is one of the major ligands for activating immune-receptor NKG2D which is expressed on NK cells and cytotoxic T lymphocytes. The release and sustained expression of MICA protein can impair NKG2D-mediated cytotoxic activity by reducing NKG2D receptor on immune effector cells....
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：:Urokinase (uPA) plays an essential role in the activation of plasminogen to plasmin, and together with its receptor (uPAR), tissue activator (tPA) and urokinase inhibitors (PAI 1, PAI 2, PAI 3 and protease nexin) forms the plasminogen activator system (PAS), a component of metastatic cascade importantly contributing t...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2011_05_377
更新日期：2011-01-01 00:00:00
abstract：:This study aimed to investigate the effects of RhoGDIα knockdown on apoptosis and the chemosensitivity of lung cancer cells to paclitaxel. The signaling proteins involved were also assessed. RhoGDIα expression was assessed by RT-PCR, Western blotting and immunohistochemistry. Apoptosis was determined by flow cytometri...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2012_070
更新日期：2012-01-01 00:00:00
abstract：:Peroxisome proliferator activated receptor delta (PPARD) is a nuclear receptor transcription factor whose single nucleotide polymorphism (SNP), especially PPARD-87 T>C (rs2016520), may play an important role in expression regulation of PPARD. But its expression patterns as well as contribution in colorectal cancer (CR...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2018_181012N763
更新日期：2019-07-23 00:00:00
abstract：:Immunohistochemistry (IE) and polymerase chain reaction (PCR) are tools enabling to find small number of tumor cells in lymph nodes (LNs) or peripheral blood. Perhaps these methods will allow early detection of cell dissemination and refine risk group within papillary thyroid cancer (PTC) that might benefit from more ...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：:This study comprises 46 patients with various stages of breast carcinoma and 49 normal women as control group. Serum xanthine oxidase and uric acid levels were determined. Assessment in terms of changes of the enzyme xanthine oxidase was carried out prior and after surgery as a short term follow up. There was a signif...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:MSH-PE38KDEL is a chimeric molecule composed of MSH, and fused to a truncated mutant form of Pseudomonas exotoxin (PE38KDEL). Our study aims to evaluate the specific cytotoxicity of recombinant immunotoxin MSH-PE38KDEL on melanoma cells A875 and B16 in vitro, as well as its inhibition of metastatic melanoma in vivo. M...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2014_048
更新日期：2014-01-01 00:00:00
abstract：:Induction of 6-thioguanine-resistant mutations was studied in Chinese hamster V79 cells treated with nitrofurylacrylic acid under aerobic and hypoxic conditions. The results obtained demonstrated that the mutagenic activity of this substance, less significant in aerobic conditions, was very high under hypoxic conditio...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：:Serial cytogenetic characteristics of four lymphoblastoid cell lines derived from the peripheral blood of four patients with acute leukemia are presented, including G and C banding techniques and the analysis of sister chromatid exchanges by means of FPG technique. One of these lines turned into predominantly diploid ...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
abstract：:Eighty-eight patients with histologically confirmed colon cancer and two control groups individually matched by age, sex and place of residence, were interviewed about demographic, biosocial and medical variables. The use of laxatives, past history of large bowel disease and coffee consumption for 20 or more years wer...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:Analysis of new primary tumors following nonmelanoma skin cancers (NMSC) has a public health and risk assessment interest, as well as potential implications for etiologic inference. The aim of this study is to evaluate the risk of the second primary tumors occurrence after NMSC development. A cohort of 2620 cases (133...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:The growth of transplanted Bomirski melanoma in hamsters is accompanied by the decrease of natural killer cytotoxic activity and the formation of metastases. The excision of primary tumors was carried out to examine what was the effect of the growing tumor and its metastases on the host's NK activity. It was found tha...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:Using the exocolonizing test, 59Fe-utilization technique and classical cytology, the authors observed 210 days after i.v. injection of 166.7 kBq of 239Pu/kg in about 30% of contaminated mice a proliferative activity in vertebral bone marrow, characterized with high relative numbers of pluripotent hemopoietic stem cell...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:Effect of pentoxifylline (PTX) on vincristine (VCR) resistance of multidrug resistant L1210/VCR mouse leukemic cell line was studied. Reversal effect of PTX (in concentration 50-150 mg/l) on vincristine resistance, i.e. potentiation of vincristine cytotoxicity on L1210/VCR cells by PTX was found. PTX alone in the abov...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
