Abstract：
:Since the prevention of apoptosis can produce resistance to chemotherapy, abnormal expression of oncoproteins engaged in the regulation of this phenomenon in tumor cells may give some prognostic information in patients with neoplasma. To assess this problem in Hodgkin's disease (HD), the cellular expression of two p53 downstreams proteins p21 and MDM-2 was evaluated in the lymph nodes specimens obtained from 68 patients at the time of diagnosis, and compared with some clinical and pathological data. Positive immunoreaction for p21 and MDM-2 on Reed-Sternberg/Hodgkin's (R-S/H) cells was found in a majority of cases (58.8 and 63.2%, respectively). High expression of p21 protein correlated with poor response to the first-line treatment and disease free survival in both univariate and multivariate regression analysis, whereas expression of MDM-2 did not give prognostic information in patients with HD. Expression of p21 and MDM-2 was also compared with p53 protein immunoreactivity of R-S/H cells. The p21+/p53+ immunophenotype occurred to give particularly negative prognostic information in patients with HD. Diversity of p21/MDM-2/p53 patterns of R-S/H cells observed in particular patients may reflect heterogeneity of apoptosis regulatory mechanisms, as well as differences in p53 gene status.
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Smolewski P,Niewiadomska H,Krykowski E,Robak Tsubject
Has Abstractpub_date
1999-01-01 00:00:00pages
212-8issue
4eissn
0028-2685issn
1338-4317journal_volume
46pub_type
杂志文章相关文献
NEOPLASMA文献大全abstract：:A 65-kDa tumor-associated protein (P65) is a potential non- specific tumor marker expressed by many types of tumor cells. Our recent studies indicate that P65 gene expression is connected with poor prognosis for the patients with colorectal cancer. In the present study P65 gene expression was determined by means of RT...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：:Using the model of Sarcoma I (SaI) (H-2a) tumor allograft transplanted to normal B10 (H-2b) mice and to B10 mice pretreated with ATS, we studied the effects of anti-Thy-1,2 monoclonal antibody (MTA) and compared them with those of rabbit polyvalent antiserum against mouse thymocytes (ATS). When administered shortly be...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:In a series of 52 biopsy specimens (31 endometrial carcinomas, 10 atypical endometrial hyperplasias, and 11 cases of normal endometrium), DNA ploidy and S-phase cell fraction were estimated in paraffin-embedded material. DNA aneuploidy was detected in 2 of the 10 atypical endometrial hyperplasias and 7 of the 31 endom...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:Chromosomal aberrations in bone marrow and lymph node cells have been investigated in 47 patients with lymphogranulomatosis 24--72 hr after administration of a single therapeutic dose of cyclophosphan and natulan. It is shown that the injurious action of cyclophosphan and natulan lasts more than 72 hr. An analysis of ...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
abstract：:Analysis of new primary tumors following nonmelanoma skin cancers (NMSC) has a public health and risk assessment interest, as well as potential implications for etiologic inference. The aim of this study is to evaluate the risk of the second primary tumors occurrence after NMSC development. A cohort of 2620 cases (133...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:Circular RNAs (circRNAs) are a class of newly-identified non-coding RNA molecules. CircRNAs are conserved across different species and display specific organization, sequence, and expression in disease. Moreover, circRNAs' closed ring structure, insensitivity to RNase, and stability are advantages over linear RNAs in ...
journal_title：Neoplasma
pub_type： 杂志文章,评审
doi：10.4149/neo_2017_301
更新日期：2017-01-01 00:00:00
abstract：:The paclitaxel represents first agent from novel class of antineoplastic drugs-taxoids. The clinical development of paclitaxel was initially hampered by hypersensitivity reactions. Current dosage regiments with premedication reduced the incidence of these side effects to less than 3%. The major dose-limiting adverse e...
journal_title：Neoplasma
pub_type： 杂志文章,评审
doi：
更新日期：1996-01-01 00:00:00
abstract：:The growth of transplanted Bomirski melanoma in hamsters is accompanied by the decrease of natural killer cytotoxic activity and the formation of metastases. The excision of primary tumors was carried out to examine what was the effect of the growing tumor and its metastases on the host's NK activity. It was found tha...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:IgA1-2 subclass distribution was determined in a series of 62 sera with diagnosed IgA paraprotein. Throughout the series the participation of IgA1 : IgA2 subclasses showed a ratio 9 : 1 even after division of the series into myeloma and nonmyeloma paraproteinemias. On dividing the series according to the antigenic typ...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:The aim of the presented study was to evaluate the long-term outcome of breast-conserving surgery and radiation for the treatment of ductal carcinoma in situ (DCIS) and the role of the radiation boost to the tumor bed. The files of 75 women with DCIS treated by breast-conserving surgery followed by definitive radiatio...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:The cytostatic activity of 2-thio-4-hydrazinouracil (THU) on some transplantable tumors has been studied. A strong effect of this compound (between 60% and 100% suppression) has been found in the case of Myeloma P-8 (MOPC-21) and Sarcoma 180 (Crocker). A less pronounced effect has been observed on Yoshida sarcoma, whi...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1975-01-01 00:00:00
abstract：:CD147, a widely expressed cell surface glycoprotein in cancer, is associated with tumor invasiveness and chemotherapy resistance. Recently, CD147 is also regarded as a potential therapeutic target for cancer therapy. The aim of the study was to investigate CD147 expression in non-small cell lung cancer (NSCLC), and ev...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2011_05_449
更新日期：2011-01-01 00:00:00
abstract：:5-Azacytidine administered to male mice prior to mating resulted in their decreased fertility and in the loss of offsprings at different periods of embryonic and postnatal development. The drug interfered with mature spermatozoa and spermatids; considerable distortion of cellular associations in seminiferous epitheliu...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:We report in this study that microRNA-584-3p (miR-584-3p) is related to the vasculogenic mimicry (VM) of human glioma cells. Unsurprisingly, the postoperative survival time was significantly prolonged in those glioma patients without VM phenomena compared with those with positive VM. miR-584-3p may function as a poten...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2017_102
更新日期：2017-01-01 00:00:00
abstract：:The level of lipid-bound sialic acid (LSA) was followed in inbred C57Bl/6 mice bearing tumors induced by benzpyrene at a dose of 20 mg per kg of body weight. In the plasma of mice with macroscopically ascertained tumors, the level of LSA was increased significantly. The LSA level was also significantly increased in th...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:In a group of 11,153 autopsied subjects a higher number of cholecystectomies was found in both sexes in individuals with large intestine tumors as compared with the rest of the autopsied persons without tumors (p less than 0.001). The results confirmed the hypothesis that cholecystectomy is a supporting factor in the ...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:In a series of 25 patients with cervical carcinoma and 35 patients with vulvar carcinoma, clinically classified (FIGO) as Stage I and Ib, respectively, DNA ploidy and S-phase cell fraction were estimated in paraffin-embedded samples of the primary tumors and their metastases by means of flow cytometry (FCM). The two g...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:The expression of cytokeratins 7, 8, 14, 18, 19 and vimentin was examined in 100 cases of ductal invasive breast carcinomas. While the predominantly diffuse immunohistological positivity of simple epithelia cytokeratins 7 (in 93), 8 (in 100), 18 (in 100) and 19 (in 97) cases represents a constant feature of these tumo...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:This study aimed to identify the oncogenes associated with lung cancer based on the mRNA and single nucleotide polymorphism (SNP) profile data. The mRNA expression profile data of GSE43458 (80 cancer and 30 normal samples) and SNP profile data of GSE33355 (61 pairs of lung cancer samples and control samples) were down...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2015_117
更新日期：2015-01-01 00:00:00
abstract：:Multiple myeloma (MM) is a hematological malignancy caused by clonal proliferation of malignant plasma cells (PC). The aim of the work is to determine prognostic significance of morphological subtypes of PC in relation to overall treatment response, long-term survival and other conventional prognostic parameters. One ...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2011_06_554
更新日期：2011-01-01 00:00:00
abstract：:Thymus, spleen and lymph nodes from myeloid leukemic mice (Graffi) were examined by light and electron microscope using immunoperoxidase techniques. As immune sera autologous sera were applied. The percentage of the labeled leukemic cells ranged from 30 to 60. It was established that leukemic cell associated antigen(s...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：:To explore how Tim-3 is expressed and how its expression influences invasion and metastasis of colorectal cancer (CRC) cells. A total of 188 CRC patients were prospectively collected for this study. Meanwhile, 135 normal controls were incorporated during the same period. Intestinal samples of the CRC radical cancerous...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2017_112
更新日期：2017-01-01 00:00:00
abstract：:Dendritic cells are able to induce anti-tumor immune responses by presenting tumor-specific antigens to T-lymphocytes. Various tumor-associated antigens have been studied in multiple myeloma in an effort to find a strong antigen capable of generating clinically meaningful responses in vaccinated patients. The aim of o...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2010_05_455
更新日期：2010-01-01 00:00:00
abstract：:We evaluated the prognostic impact of chromosomal abnormalities as detected by interphase fluorescence in situ hybridization (iFISH) in 86 chronic lymphocytic leukemia (CLL) patients. Overall, 39 of 86 (45%) patients displayed one (35%) or more (10%) chromosomal abnormalities, del13q (31%) being more frequently detect...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2011_01_82
更新日期：2011-01-01 00:00:00
abstract：:The influence of two kinds of transplantable melanomas on the secretory function of peritoneal macrophages, and particularly the release of TNF-alpha has been studied. The results showed a statistically significant increase of protein content in the supernatants from 24 h cultured macrophages from melanoma-bearing ham...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:PMP22 is recently recognized as a key player in a variety of prevalent cancers. In this study, we sought to explore the correlation of peripheral myelin protein 22 (PMP22) expression with cell proliferation, invasion and apoptosis in lung cancer cell line. miR29 was transfected into Anip973 lung adenocarcinoma cell li...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2015_107
更新日期：2015-01-01 00:00:00
abstract：:The cytostatic cytokine tumor necrosis factor-alpha (TNF-alpha) and proliferative hormone adrenomedullin (AM) are abundantly expressed in human tumors. However, little is known about mechanism (s) through which TNF-alpha and AM exert their regulatory effects, especially in the regulation of proliferative activity in m...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:The effect of a crude protein fraction from human urine having gonadotropin inhibitory activity (GGIM) was observed on the growth of 7,12-dimethylbenz(a)anthracene induced mammary tumors in Holtzman rat. Results show that while in 12 out 13 tumors, tumor growth was retarded/regressed following 2--4 weeks of CGIM treat...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:The effect of dibutyryl cyclic nucleotides, dbcAMP and dbcGMP, on the growth of BSC-1 cells has been studied in the presence and absence of kidney epithelial cell growth inhibitor. The growth response of the cells was dependent on concentrations of the dibutyryl cyclic nucleotides and on the presence or absence of ser...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:The concentration of estradiol and progesterone receptors in tumor cytosol from human breast cancer patients represents an important factor for the selection of patients for endocrine therapy and for the prognosis of the disease. This report presents results obtained by measurement of estradiol receptor in 157 breast ...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
