Enhanced mortality in offsprings of male mice treated with 5-azacytidine prior to mating. Morphological changes in testes.

abstract：:Metadherin (MTDH) is an oncoprotein and is expressed at high levels in a wide variety of human carcinomas, which represents an important genetic determinant and regulates multiple events in tumorigenesis. MTDH promotes breast cancer cell proliferation and tumorigenesis through the activation of numerous signaling path...

journal_title：Neoplasma

authors： Chen X,Li XY,Long M,Wang X,Gao ZW,Cui Y,Ren J,Zhang Z,Liu C,Dong K,Zhang H

更新日期：2018-01-01 00:00:00

abstract：:MHC class I chain-related molecule A (MICA) is one of the major ligands for activating immune-receptor NKG2D which is expressed on NK cells and cytotoxic T lymphocytes. The release and sustained expression of MICA protein can impair NKG2D-mediated cytotoxic activity by reducing NKG2D receptor on immune effector cells....

journal_title：Neoplasma

authors： Lu SM,Xiao P,Xue L,Che LH,Yang P,Li Y,Qiao H

更新日期：2008-01-01 00:00:00

abstract：:Mammalian target of rapamycin (mTOR) has two subtypes, i.e., mTORC1 and mTORC2, which contain the Raptor and Rictor core molecules, respectively. The effect of Raptor and Rictor on hypoxia inducible factor (HIF)-1α, HIF-2α, and vascular endothelial growth factor (VEGF) in colorectal cancer (CRC) is unclear. In this wo...

journal_title：Neoplasma

authors： Wen FF,Li XY,Li YY,He S,Xu XY,Liu YH,Liu L,Wu SH

更新日期：2020-05-01 00:00:00

abstract：:Genomic, epigenetic and expression alterations of WW domain containing oxidoreductase (WWOX) have been implicated in multiple tumor types. The current study was designed to examine the expression of WWOX in tumor tissues of human bladder transitional cell carcinoma (BTCC) and the influence of cigarette smoke extract (...

journal_title：Neoplasma

authors： Yang W,Cui S,Ma J,Lu Q,Kong C,Liu T,Sun Z

更新日期：2012-01-01 00:00:00

abstract：:The aim of our work was to develop a fast, reliable and sensitive PCR method to detect K-ras mutations in various clinical samples. There is a need for an unimpeachable method for early diagnosis and/or screening of pancreatic cancer (PC). We optimized and subsequently analyzed four methods based on mutant-enriched PC...

journal_title：Neoplasma

authors： Ugorcáková J,Hlavatý T,Babál P,Janega P,Bukovská G,Halgasová N,Hlavatá A,Timko J,Duris I

更新日期：2006-01-01 00:00:00

abstract：:The Carr-Zilber strain of Rous sarcoma virus is highly oncogenic for adult monkeys of the species Macaca mulata. In the present study, we examined some characteristics of tumor growth when the tumor either regressed or progressed until it killed its host. We followed the kinetics of antibody formation to antigens code...

journal_title：Neoplasma

authors： Adgighitov FI,Gubeladze DA,Lapin BA,Hlozánek I,Sovová V,Cerná H

更新日期：1980-01-01 00:00:00

abstract：:Human immediate early response 2 (IER2) has been implicated in tumor cell motility and metastasis; however, the underlying mechanisms in hepatocellular carcinoma (HCC) metastasis remain to be clarified. In this study, we demonstrate that dysregulation of IER2 was shown in HCC clinical samples, and IER2 expression resu...

journal_title：Neoplasma

authors： Xu X,Zhou W,Chen Y,Wu K,Wang H,Zhang J,Zhou Y,Zeng J,Yang J,Deng Z,Zhang Y,Shen W

更新日期：2020-05-01 00:00:00

abstract：:Alteration of the p53 tumor suppressor gene is the most common genetic defect known to occur in human tumors. Germ-line p53 mutations significantly increase the risk of developing diverse malignancies. FASAY is a simple functional assay for germ-line and somatic mutations in the p53 gene altering the transactivation c...

journal_title：Neoplasma

authors： Smardová J

更新日期：1999-01-01 00:00:00

abstract：:Transcription factor 21 (TCF21) has been identified as a candidate tumor suppressor at 6q23-q24 that is epigenetically inactivated in many types of human cancers. We recently found that TCF21 methylation level was significantly increased in clear cell renal cell carcinoma (ccRCC). The purpose of this study was to inve...

journal_title：Neoplasma

authors： Ye YW,Jiang ZM,Li WH,Li ZS,Han YH,Sun L,Wang Y,Xie J,Liu YC,Zhao J,Tang AF,Li XX,Guan ZC,Gui YT,Cai ZM

更新日期：2012-01-01 00:00:00

abstract：:Carcinoma of oral cavity have a high risk of recurrence after initial treatment with surgery, radiotherapy, surgery with adjuvant radiotherapy, or radio-chemotherapy.The present study investigated the changes in expression, activity and regulation of matrix metalloproteinases (MMP) -2 and -9 in oral squamous cell carc...

journal_title：Neoplasma

authors： Nanda DP,Dutta K,Ganguly KK,Hajra S,Mandal SS,Biswas J,Sinha D

更新日期：2014-01-01 00:00:00

abstract：:A report on 1877 consecutive node negative (N-) breast cancer cases is presented in which the prognostic value of the main clinico-pathologic features is evaluated. Tumor size (and UICC-TNM T category) and lobular infiltrating histologic type were significantly associated with a more favorable prognosis whereas no ass...

journal_title：Neoplasma

authors： Ciatto S,Cecchini S,Grazzini G,Iossa A,Bartoli D,Rasponi A

更新日期：1990-01-01 00:00:00

abstract：:Sixty-five patients with Stage I and II endometrial carcinoma were investigated. After a short-time follow-up (17-24 months) significant differences in frequency of relapses were observed between patients with tumors containing low amounts of estrogen receptor (ER less than 60 fmol/mg DNA) in the nuclear pellet, and t...

journal_title：Neoplasma

authors： Horvath G,Johnsson JE,Tropé C,Samuelsson L,Alm P,Olsson H

更新日期：1990-01-01 00:00:00

abstract：:This study aimed to identify the oncogenes associated with lung cancer based on the mRNA and single nucleotide polymorphism (SNP) profile data. The mRNA expression profile data of GSE43458 (80 cancer and 30 normal samples) and SNP profile data of GSE33355 (61 pairs of lung cancer samples and control samples) were down...

journal_title：Neoplasma

authors： Wang Y,Mei Q,Ai YQ,Li RQ,Chang L,Li YF,Xia YX,Li WH,Chen Y

更新日期：2015-01-01 00:00:00

abstract：:Application of hyperimmune rabbit antisera against mouse lymphomas (6C3HED lymphoma, NK lymphoma) or against rat leukemic cells (RBA-34-Le leukemia) caused a considerable degree of lymphocyte depletion in hamsters. ...

journal_title：Neoplasma

authors： Oravec C,Ondrus B

更新日期：1977-01-01 00:00:00

abstract：:Glioma is among the most fatal brain tumors characterized by a highly malignancy and rapid progression and early metastasis. Dysregulation of long non-coding RNA differentiation antagonizing non-protein coding RNA (LncRNA DANCR) is associated with the development, progression and metastasis of various cancers. In the ...

journal_title：Neoplasma

authors： Yang JX,Sun Y,Gao L,Meng Q,Yang BY

更新日期：2018-09-19 00:00:00

abstract：:Weanling ICRC female mice were given syngeneic neonatal thymus graft under renal capsule and two weeks later whole-body gamma-radiation (group ITR). The findings on ITR were compared with three controls--untreated (C), thymus grafted (IT) and irradiated (IR). In ITR group 15/15 developed generalized neoplasms of retic...

journal_title：Neoplasma

authors： Pai SR,Sequeira B

更新日期：1985-01-01 00:00:00

abstract：:The immunogenic properties of MC-induced and not metastasizing tumors were tested in inbred Wistar and August strains by the aid of lymphocyte stimulation in syngeneic draining lymph nodes in the comparison with the opposite ones. The lymphocyte stimulation was estimated in vitro by the spontaneous incorporation of 3H...

journal_title：Neoplasma

authors： Ryzewska AG,Rybicka M,Kania A,Dabrowski M

更新日期：1980-01-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) a proinflammatory cytokine with multiple actions was first identified for its anticancer activity. However, TNF-alpha has a beneficial function in activation of host defense, its uncontrolled production can lead to pathological consequences. At the cellular level, it is able to ...

journal_title：Neoplasma

authors： Szatmáry Z

更新日期：1999-01-01 00:00:00

abstract：:Vincristine sensitive (L1210) and resistant (L1210/VCR) L1210 mouse leukemia cells were studied from morphological and histochemical point of view. The morphological and histochemical findings reflected differences in membrane structure and in physiological state of sensitive and resistant cells. Numerous villous proj...

journal_title：Neoplasma

authors： Uhrík B,Tribulová N,Klobusická M,Barancík M,Breier A

更新日期：1994-01-01 00:00:00

abstract：:Multiple myeloma (MM) is a hematological malignancy caused by clonal proliferation of malignant plasma cells (PC). The aim of the work is to determine prognostic significance of morphological subtypes of PC in relation to overall treatment response, long-term survival and other conventional prognostic parameters. One ...

journal_title：Neoplasma

authors： Al-Sahmani M,Trnavska I,Sevcikova S,Antosova M,Antosova L,Kissova J,Adam Z,Pour L,Nemec P,Greslikova H,Krejci M,Zahradova L,Bulikova A,Penka M,Hajek R

更新日期：2011-01-01 00:00:00

abstract：UNLABELLED:The current study aimed to evaluate the efficacy of sorafenib-based combined therapy against hepatocellular carcinoma (HCC). HepG2 cells were exposed to sorafenib, irinotecan, and oxaliplatin and then subjected to MTT assay to determine chemosensitivity. Flow cytometry was used to examine cell cycle distribu...

journal_title：Neoplasma

authors： Wang Z,Zhao Z,Wu T,Song L,Zhang Y

更新日期：2015-01-01 00:00:00

abstract：:Relation between the electronic structure of aromatic compounds and their carcinogenic activity has been correlated. Hypotheses of K, L regions have been employed. Possibilities of better theoretical description of carcinogenic activity have been examined by including the effect of medium and by using a more exact qua...

journal_title：Neoplasma

authors： Miertus S

更新日期：1979-01-01 00:00:00

abstract：:In comparison with the 7th Edition, the 8th Edition of the American Joint Committee on Cancer (AJCC) staging system no longer considers the mitotic count in the a or b T1 categorization for melanoma, but it adopts a sub-stratification based on the Breslow's depth. Today, the death burden of thin melanoma is still seve...

journal_title：Neoplasma

authors： Roncati L,Piscioli F

更新日期：2018-09-19 00:00:00

abstract：:Cytolytic activity of mineral oil elicited rat peritoneal macrophages activated by lipopolysaccharide (LPS) and/or rIFN-gamma, rIL-2, Zymosan and PMA (4-beta-phorbol-12-beta-myristate 13-alpha-acetate) was detected in the presence of various concentrations of L-arginine. This paralleled the NO2- production in the pres...

journal_title：Neoplasma

authors： Kusenda J,Kalafut F,Klobusická M,Novotná L

更新日期：1992-01-01 00:00:00

abstract：:Oral cancer is one of the common cancers worldwide, among which over 90% are oral squamous cell carcinomas (OSCC). MicroRNAs act as critical regulators of cancer development and progression. MiR-103a-3p has been reported to be upregulated in OSCC patients and closely correlated to poor prognosis, yet its roles in the ...

journal_title：Neoplasma

authors： Zhang G,Chen Z,Zhang Y,Li T,Bao Y,Zhang S

更新日期：2020-05-01 00:00:00

abstract：:Peroxisome proliferator activated receptor delta (PPARD) is a nuclear receptor transcription factor whose single nucleotide polymorphism (SNP), especially PPARD-87 T>C (rs2016520), may play an important role in expression regulation of PPARD. But its expression patterns as well as contribution in colorectal cancer (CR...

journal_title：Neoplasma

authors： Luo B,Yang HW,Long FW,Zhou B,Lv ZY,Cheng KL,Li Y,Zhou ZG,Sun XF

更新日期：2019-07-23 00:00:00

abstract：:Olfactomedin 4 (OLFM4) is a member of olfactomedin domain-containing protein family. Human OLFM4 is preferentially expressed in the gastrointestinal tract (stomach, small intestine and colon), prostate, and bone marrow. Recent studies demonstrate that OLFM4 is involved in the establishment and/or development of some t...

journal_title：Neoplasma

authors： Yu L,Wang L,Chen S

更新日期：2011-01-01 00:00:00

abstract：:Inaccuracy, inadequate use of histooncological diagnosis and deficient use of the diagnostic scope have been found in our set of examinations. Responsibility for diagnostic errors resided most frequently in poor knowledge of the problem. Therefore more consistent postgraduate training in histooncological classificatio...

journal_title：Neoplasma

authors： Bednár B

更新日期：1988-01-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) is a diverse group of cancers that are frequently aggressive in their biologic behavior. Inactivation of tumor suppressor gene (TSG) is one of the most critical steps leading to HNSCC. Loss of heterozygosity analysis is very sensitive method for the detection of frequent a...

journal_title：Neoplasma

authors： Cetin E,Cengiz B,Gunduz E,Gunduz M,Nagatsuka H,Bekir-Beder L,Fukushima K,Pehlivan D,N MO,Nishizaki K,Shimizu K,Nagai N

更新日期：2008-01-01 00:00:00

abstract：:Lung cancer is a common malignant disease in humans. Both the incidence rate and death rate keep growing in recent years and the prognosis of lung cancer patients is disappointing. Melanoma inhibitory activity (MIA) is a secreted protein and a serum marker for metastasis of melanoma. MIA was reported as an oncogene in...

journal_title：Neoplasma

authors： Gu QH,Li D,Xie ZH,Shen QB

更新日期：2020-05-01 00:00:00