Abstract：
:We evaluated the prognostic impact of chromosomal abnormalities as detected by interphase fluorescence in situ hybridization (iFISH) in 86 chronic lymphocytic leukemia (CLL) patients. Overall, 39 of 86 (45%) patients displayed one (35%) or more (10%) chromosomal abnormalities, del13q (31%) being more frequently detected than trisomy 12 (19%) followed by del11q (17%), del17p (6%) and del6q (5%). Significant differences in the treatment free intervals (TFIs) were observed among individual cytogenetic subgroups (p=0.027) with the shortest mean TFIs in subgroups with del17p, del11q and trisomy 12 (10, 12 and 14 months, respectively) as compared to subgroups with normal cytogenetics (38 months) and del13q (68 months). Poor response to therapy was observed in subgroups with del11q (p=0.044) and trisomy 12 (p=0.047) while patients with normal cytogenetics had good response (p=0.003). Furthermore, del17p and del11q were associated with highest tumor burden and disease activity as reflected by corresponding laboratory data.
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Giertlova M,Hajikova M,Vaskova J,Kafkova A,Stecova N,Mirossay L,Karabinos A,Tothova E,Sarissky Mdoi
10.4149/neo_2011_01_82subject
Has Abstractpub_date
2011-01-01 00:00:00pages
82-8issue
1eissn
0028-2685issn
1338-4317journal_volume
58pub_type
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