Abstract：
:Rearrangement and loss of genetic material in DNA of human ductal breast carcinoma was analyzed by restriction enzyme digestion, agarose gel electrophoresis and Southern blot hybridization using 32P labeled c-Ha-ras-1 and multilocus, minisatellite 15.1.11.4 as a probe. In several cases an allelic loss of c-Ha-ras-1 locus in heterozygous patients were noticed. Rearrangement of the genetic material in neoplastic tissues was also observed after hybridization with a minisatellite probe. These results provide evidence that loss and redistribution of the genetic material does occur in human ductal breast carcinoma.
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Mackiewicz M,Choina B,Kadlof A,Szala Ssubject
Has Abstractpub_date
1988-01-01 00:00:00pages
549-54issue
5eissn
0028-2685issn
1338-4317journal_volume
35pub_type
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