Aminopeptidases and angiotensin I-converting enzyme activities in primary human lung tumors and lung parenchyma.

Abstract:

:The activities of alanyl aminopeptidase (AAP), arginyl aminopeptidase (RAP), alpha-glutamyl aminopeptidase (EAP) and angiotensin I-converting enzyme (ACE) were investigated in primary human lung tumors of different histological types and in matched lung parenchyma. In contrast to the studied aminopeptidases whose activity differences between tumor and lung tissues were infrequently significant, the activity of ACE was decreased highly significantly in the majority of lung tumors.

journal_name

Neoplasma

journal_title

Neoplasma

authors

Procházka J,Krepela E,Sedo A,Viklický J,Fiala P

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

501-8

issue

5

eissn

0028-2685

issn

1338-4317

journal_volume

38

pub_type

杂志文章
  • Alteration of the microRNA expression profile in human osteosarcoma cells transfected with APE1 siRNA.

    abstract::Apurinic/apyrimidinic endonuclease1 (APE1), which has the dual functions of DNA repair and redox regulation, is considered to be a promising potential target in cancer treatment. Microarray and qRT-PCR were used to confirm the change of miRNA followed by analysis with comprehensive bioinformatics-based analysis. Both ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2013_050

    authors: Dai N,Zhong ZY,Cun YP,Qing Y,Chen Ch,Jiang P,Li MX,Wang D

    更新日期:2013-01-01 00:00:00

  • Dental pulp mesenchymal stem/stromal cells labeled with iron sucrose release exosomes and cells applied intra-nasally migrate to intracerebral glioblastoma.

    abstract::We report on a simple iron oxide (Venofer) labeling procedure of dental pulp mesenchymal stem cells (DP-MSCs) and DP-MSCs transduced with yeast cytosinedeaminase::uracilphosphoribosyltransferase (yCD::UPRT-DP-MSCs). Venofer is a drug approved for intravenous application to treat iron deficiency anemia in patients. Ven...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2016_611

    authors: Altanerova U,Benejova K,Altanerova V,Tyciakova S,Rychly B,Szomolanyi P,Ciampor F,Cihova M,Repiska V,Ondicova K,Mravec B,Altaner C

    更新日期:2016-01-01 00:00:00

  • Breast and other cancer deaths in a mental hospital.

    abstract::The neuroleptics, well known as stimulants of prolactin release, are supposed to increase breast cancer incidence. To verify this hypothesis, we selected a group of 853 deaths of female inpatients with mental diseases recorded in the Dr. G. Marinescu Hospital between 1929 and 1978. Using proportionally and indirect st...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Costa D,Mesteş E,Coban A

    更新日期:1981-01-01 00:00:00

  • Upregulated circZMIZ1 promotes the proliferation of prostate cancer cells and is a valuable marker in plasma.

    abstract::Increasing evidences have proved that circular RNAs (circRNAs), identified as a specific kind of non-coding RNAs, play a potential critical role in tumorigenesis including prostate cancer. However, the function of circRNAs in human prostate cancer remain largely unknown. In this study, we demonstrated that the express...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2019_190213N116

    authors: Jiang H,Lv DJ,Song XL,Wang C,Yu YZ,Zhao SC

    更新日期:2020-01-01 00:00:00

  • The current look at high-dose chemotherapy in breast cancer minireview.

    abstract::High-dose chemotherapy (HDC) in high-risk breast cancer is one of the possible approaches how to improve therapeutic results, eventually, to overcome the incurability of the disease. In recent randomized studies superiority of HDC to conventional therapy has not been unambiguously established. Nevertheless, many oncol...

    journal_title:Neoplasma

    pub_type: 杂志文章,评审

    doi:

    authors: Filip S,Petera J,Odrázka K,Bláha M

    更新日期:2000-01-01 00:00:00

  • Colorectal carcinoma and cholecystectomy.

    abstract::In a group of 11,153 autopsied subjects a higher number of cholecystectomies was found in both sexes in individuals with large intestine tumors as compared with the rest of the autopsied persons without tumors (p less than 0.001). The results confirmed the hypothesis that cholecystectomy is a supporting factor in the ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Hladík V,Nozicka Z,Maslowská H

    更新日期:1987-01-01 00:00:00

  • Toll-like receptor 2 gene polymorphisms and cancer susceptibility: a meta-analysis.

    abstract::To date, epidemiological studies have assessed the association between Toll-like receptor 2 (TLR2) gene polymorphisms and cancer risk. However, the results of these studies remain controversial. We aimed to examine the associations between three SNPs (Delta22, rs3804099 and rs3804100) of TLR2 gene and cancer risk by c...

    journal_title:Neoplasma

    pub_type: 杂志文章,meta分析

    doi:10.4149/neo_2013_060

    authors: Wang X,Li J,Xie W,Zhang W,Chang Y

    更新日期:2013-01-01 00:00:00

  • Differential effect of protein kinase inhibitors (staurosporine and CGP 41,251) on TPA-induced homotypic aggregation and cell surface adhesion antigen expression in human monoblastoid cell line U-937.

    abstract::The phorbolester (TPA)-induced homotypic aggregation of human monoblastoid U-937 cells was completely abolished by staurosporine, but not by a new selective protein kinase C inhibitor, benzoylated staurosporine derivative CGP 41,251, a compound with known anti-tumor and drug resistance modulating activity. Staurospori...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Sedlák J,Sulíková M,Hunáková L,Chorváth B

    更新日期:1995-01-01 00:00:00

  • Cells producing recombinant retrovirus with thymidine kinase gene from Herpes simplex virus suitable for human cancer gene therapy.

    abstract::Therapeutic cells producing amphotropic retrovirus, which are able to transduce in vivo thymidine kinase gene of Herpes simplex virus were prepared. Single-cell clone cells with high virus productivity (PA-3 17JH5c113) were obtained by cell cloning. The cells were found free of replication competent retrovirus, they w...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Hlavatý J,Hlubinová K,Bies J,Altaner C

    更新日期:1999-01-01 00:00:00

  • Hematological and cytogenetic response of interferon alpha 2b alone and combined interferon alpha plus cytarabine as a first-line treatment in chronic myeloid leukemia.

    abstract::Treatment with interferon-alpha (IFNalpha) prolongs survival in chronic myeloid leukemia (CML). Additionally, cytarabine (AraC) can reduce the number of Ph + metaphases. Fortythree previously untreated patients with CML in chronic phase were randomly assigned to receive either. IFNalpha 2b (5 MU sqm/daily) or IFNalpha...

    journal_title:Neoplasma

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors: Tóthová E,Fricová M,Kafková A,Stecová N,Guman T,Raffac S,Hlebasková M

    更新日期:2000-01-01 00:00:00

  • Clastogenic effects of N-nitrosodimethylamine and dinitrosoglycolurile in murine bone marrow cells and cow lymphocytes.

    abstract::The clastogenic effects of N-nitrosodimethylamine (N-DMA) and dinitrosoglycolurile (DNSGU) were studied in the bone marrow of mice and in peripheral blood lymphocytes of cows. None of the tested compounds showed significant enhancement of chromosome aberrations at doses 1/2 LD50 and 1/10 LD50 in murine bone marrow cel...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Siviková K

    更新日期:1994-01-01 00:00:00

  • Expression of bcl-2 protein in non-small cell lung cancer: correlation with clinicopathology and patient survival.

    abstract::Molecular genetic studies have revealed mutations in a number of oncogenes and tumor suppressor genes in lung cancer. The bcl-2 gene product (bcl-2 protein) is implicated in oncogenesis by its ability to prolong cell death through the inhibition of apoptosis. We investigated expression of bcl-2 in 84 resected human no...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Laudanski J,Chyczewski L,Niklińska WE,Kretowska M,Furman M,Sawicki B,Nikliński J

    更新日期:1999-01-01 00:00:00

  • Investigations on the methods of clinical application of a soluble BCG fraction (F70) in lung cancer.

    abstract::Several parameters for an optimal treatment scheme of a soluble BCG fraction (F70) were investigated. Among lung cancer patients treated with F70 a restricted selection was made of patients treated with small doses (5--10 U) every second or third month (sparing scheme) and of patients treated every month with sharply ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Hadźiev S,Kavaklieva-Dimitrova J,Mandulova P

    更新日期:1979-01-01 00:00:00

  • In vitro studies of a co-carcinogenic effect of vaccinia and herpes group viruses.

    abstract::The results of studies of a co-carcinogenic effect of two human infectious viruses in tissue culture are reported here. Viable vaccinia virus actively replicating in the cells of primary BALB/c tissue culture and in a number of continuous murine cell lines has been shown to induce in them expression of major structura...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Mazurenko NP,Merekalova ZI,Pavlish OA,Bykovsky AF,Kurzman MJ,Mazurenko NN

    更新日期:1981-01-01 00:00:00

  • ZNF139 promotes tumor metastasis by increasing migration and invasion in human gastric cancer cells.

    abstract::Zinc finger protein 139(ZNF139), a member of zinc finger protein family, is a transcription factor. Our previous research showed ZNF139 was overexpressed in gastric cancer cells. The purpose of present study is to explore impact and mechanism of ZNF139 on metastasis by regulating invasive ability of gastric cancer cel...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2014_037

    authors: Li Y,Tan BB,Zhao Q,Fan LQ,Wang D,Liu Y

    更新日期:2014-01-01 00:00:00

  • Are stromal fibroblasts from cervical tumors suitable to predict normal tissue radiation reaction?

    abstract::We examined the effect of gamma-irradiation (4 Gy) alone or combined with estrogen (17beta-estradiol 15 microM) treatment on the radiation response of stromal fibroblasts from cervical tumors. The fibroblasts were derived from tumors of 9 younger (<50 years) and 9 older (>50 years) cervical cancer patients. A normal f...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Gasinska A,Adamczyk A,Kojs Z,Szumiel I

    更新日期:2004-01-01 00:00:00

  • The effect of hyperthermia on the mouse testis.

    abstract::The response of different stages of spermatogenesis to heat have been assessed by scoring the cell types in testis tubules at 14, 28 and 35 days after treatment. Deficiencies in spermatids at these times can be related back to the stage that the precursor would have been in 14 and 28 days earlier. On the 35th day the ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Gasinska A,Hill S

    更新日期:1990-01-01 00:00:00

  • Fine needle aspiration biopsy in a diagnostic workup algorithm of salivary gland tumors.

    abstract::The ultrasonic diagnosis of salivary gland diseases can give a more accurate information than clinical data alone. In diagnosis of the parotid gland diseases, it is necessary to differentiate clearly tumors from other diseases. When a tumor is suspected, its presence should be confirmed, and determined if it is solita...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Ivanová S,Slobodníková J,Janská E,Jozefáková J

    更新日期:2003-01-01 00:00:00

  • Factors influencing outcome of surgery for stage I rectal cancer.

    abstract::Stage I rectal cancer (T1N0M0, T2N0M0) carries excellent prognosis with up to 90% of long term survival rates and complete cure can be expected with curative surgery. However 10 to 15% of these patients show local recurrence and mortality seen in five years. The aim of this study is to analyze the prognostic factors t...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Celen O,Yildirim E,Berberoglu U

    更新日期:2004-01-01 00:00:00

  • Combined radioprotective effect of Broncho-Vaxom and WR-2721 on hemopoiesis and circulating blood cells.

    abstract::Possibilities of combined radioprotection, using preirradiation WR-2721 administration and post- or preirradiation Broncho-Vaxom administration in lethally whole-body gamma-irradiated mice were investigated. Combined modality treatments were more effective than individual treatments alone. The ameliorative influence o...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Macková NO,Fedorocko P

    更新日期:1995-01-01 00:00:00

  • Cis-diamminedichloroplatinum in the treatment of disseminated malignant melanoma.

    abstract::The efficacy of cis-platinum in the treatment of recurrent advanced malignant melanoma is discussed and also the so far unpublished clinical data have been summed up. On account of the considerable differences among these data the clinical study of Stage II had been started which should contribute to the elucidation o...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Mechl Z,Krejcí P

    更新日期:1983-01-01 00:00:00

  • The regulation of human adrenomedullin (AM) and tumor necrosis factor alpha (TNF-alpha) receptors on human epithelial carcinoma (HeLa) cells. The role of AM secretion in tumor cell sensitivity.

    abstract::The cytostatic cytokine tumor necrosis factor-alpha (TNF-alpha) and proliferative hormone adrenomedullin (AM) are abundantly expressed in human tumors. However, little is known about mechanism (s) through which TNF-alpha and AM exert their regulatory effects, especially in the regulation of proliferative activity in m...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Drimal D,Drimal J,Drimal J Jr

    更新日期:2006-01-01 00:00:00

  • Nodal status in the papillary thyroid vancer. Comparison of the results of routine histopathological examination, immunohistochemistry and reverse transcription - polymerase chain reaction.

    abstract::Immunohistochemistry (IE) and polymerase chain reaction (PCR) are tools enabling to find small number of tumor cells in lymph nodes (LNs) or peripheral blood. Perhaps these methods will allow early detection of cell dissemination and refine risk group within papillary thyroid cancer (PTC) that might benefit from more ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Kaczka K,Jakubiak-Wielganowicz M,Zawlik I,Ziolkowski R,Kuzdak K,Pomorski L

    更新日期:2008-01-01 00:00:00

  • Podoplanin expression in cancer-associated fibroblasts correlates with VEGF-C expression in cancer cells of invasive ductal breast carcinoma.

    abstract::Podoplanin (D2-40) was shown to be expressed in cancer-associated fibroblasts (CAFs) of various malignancies. The study aimed at examining its impact on angiogenesis and lymphangiogenesis markers in invasive ductal carcinoma of the breast (IDC). The studies were performed on 104 archival cases of IDC using immunohisto...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2013_067

    authors: Pula B,Wojnar A,Witkiewicz W,Dziegiel P,Podhorska-Okolow M

    更新日期:2013-01-01 00:00:00

  • DNCB and PPD skin tests and prognosis in 152 patients with breast cancer. A prospective 2-year follow-up.

    abstract::The relationship of pretreatment immunologic status in terms of skin tests to prognosis within stages was studied in 152 breast cancer patients. DNCB and PPD testing was used. As for DNCB, no relationship was found at early stages of the disease. In locoregionally advanced disease, patients with stronger test grades h...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Munzarová M,Kovarík J,Hlávková J,Popelínský L,Lauerová L

    更新日期:1985-01-01 00:00:00

  • Risk of secondary malignancies in testicular tumors.

    abstract::The work is aimed at the occurrence of secondary malignancies after therapy for primary testicular tumors. The target of the work was determination of the number and type of secondary tumors, their effect on the survival and comparison of relative risk of the origination of secondary tumors depending on particular tre...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Siffnerova H,Kralova D

    更新日期:2007-01-01 00:00:00

  • The impact of positron emission tomography in the radiotherapy treatment planning. Minireview.

    abstract::Positron emission tomography (PET) is a new diagnostic method recently widely used in oncology. It is applied to distinguish benign and malign tumors, to diagnose relaps or posttherapeutic changes. PET is also complementary method to the standard used methods such as CT or NMR. Now it is used even as the predict facto...

    journal_title:Neoplasma

    pub_type: 杂志文章,评审

    doi:

    authors: Dolezelová H,Slampa P

    更新日期:2007-01-01 00:00:00

  • Comparison of methods used to study cell death in an adherent tumoral cell line with moderate clonogenic radiosensitivity.

    abstract::Our objective was to compare different methods for studying programmed cell death in adherent H460 non-small lung cancer cells of moderate clonogenic radiosensitivity. The major effect of gamma-radiation was found to be the release of cells from the substratum. The different methods gave complementary and unexpected i...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Broquet P,Rodriguez-Lafrasse C,Alphonse G,Aloy MT,Louisot P,Rousson R

    更新日期:2001-01-01 00:00:00

  • Prognostic validation of the WHO 2010 grading system in pancreatic insulinoma patients.

    abstract::The purpose of this study was to evaluate the prognostic potential of the World Health Organization (WHO) 2010 grading system in patients with pancreatic insulinomas. This was a retrospective study that analyzed the overall survival of 85 pancreatic insulinoma patients treated at our Institute between May 2002 and Mar...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:10.4149/neo_2015_058

    authors: Wang L,Yang M,Zhang Y,Xu S,Tian BL

    更新日期:2015-01-01 00:00:00

  • Granulocyte colony-stimulating factor demonstrates antitumor activity in melanoma model in mice.

    abstract::Granulocyte colony-stimulating factor (G-CSF) was found to exert antitumor activity against murine MmB16 melanoma when administered intratumorally. However, subcutaneous administration of this cytokine at a site distant from the growing tumor did not show any antitumor effects. G-CSF did not influence the proliferativ...

    journal_title:Neoplasma

    pub_type: 杂志文章

    doi:

    authors: Gołab J,Zagozdzon R,Stokłosa T,Kaca A,Dabrowska A,Giermasz A,Feleszko W,Jakóbisiak M

    更新日期:1998-01-01 00:00:00