Abstract：
:Granulocyte colony-stimulating factor (G-CSF) was found to exert antitumor activity against murine MmB16 melanoma when administered intratumorally. However, subcutaneous administration of this cytokine at a site distant from the growing tumor did not show any antitumor effects. G-CSF did not influence the proliferative activity of MmB16 in vitro. Intraperitoneal administration of G-CSF resulted in decreased secretion of nitric oxide (NO) by peritoneal macrophages and their decreased tumoricidal activity against MmB16.
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Gołab J,Zagozdzon R,Stokłosa T,Kaca A,Dabrowska A,Giermasz A,Feleszko W,Jakóbisiak Msubject
Has Abstractpub_date
1998-01-01 00:00:00pages
35-9issue
1eissn
0028-2685issn
1338-4317journal_volume
45pub_type
杂志文章相关文献
NEOPLASMA文献大全abstract：:DNA repair synthesis following dimethylnitrosamine (DMN) treatment in mouse liver was detected in vivo by means of histoautoradiography. This phenomenon was more significant around the acinus center (practically in all hepatocytes) than around the portobiliary space. Besides this also a decrease in semiconservative DN...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：:Loss of heterozygosity (LOH) has been shown to be an important prognostic factor in a variety of malignant neoplasm's. Cervical cancer develops as result of multiple genetic alterations. The aim of this study was to analyze presence of LOH in cervical cancer and to identify the correlation between LOH and survival and...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:Serial cytogenetic characteristics of four lymphoblastoid cell lines derived from the peripheral blood of four patients with acute leukemia are presented, including G and C banding techniques and the analysis of sister chromatid exchanges by means of FPG technique. One of these lines turned into predominantly diploid ...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
abstract：:Implantation of the RL-67 tumor in to the limb muscle of C57Bl strain mice resulted in the tumor growth at the site of implantation and the metastatic process became manifest predominantly in the lungs of all animals. A direct correlation was established between the primary tumor and its metastases. The number of meta...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
abstract：:The levels of nicotinamide adenine dinucleotide (NAD) and NADH in blood of patients with cancer in various stages of development as well as their modification after glucose administration were determined in 188 respectively 77 cases. NAD was significantly decreased in patients with cervix and breast carcinoma but unal...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:Dendritic cells are able to induce anti-tumor immune responses by presenting tumor-specific antigens to T-lymphocytes. Various tumor-associated antigens have been studied in multiple myeloma in an effort to find a strong antigen capable of generating clinically meaningful responses in vaccinated patients. The aim of o...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2010_05_455
更新日期：2010-01-01 00:00:00
abstract：:The purpose of this study was to evaluate the prognostic potential of the World Health Organization (WHO) 2010 grading system in patients with pancreatic insulinomas. This was a retrospective study that analyzed the overall survival of 85 pancreatic insulinoma patients treated at our Institute between May 2002 and Mar...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2015_058
更新日期：2015-01-01 00:00:00
abstract：:Osteosarcoma (OS) is a common malignant bone tumor that occurs in adolescents or children under the age of 20, which is extremely difficult to cure and has a high recurrence rate. Recent studies showed that cell division cycle 20 (CDC20) overexpression is associated with poor prognosis in patients with osteosarcoma. H...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2020_200614N629
更新日期：2020-10-30 00:00:00
abstract：:In comparison with the 7th Edition, the 8th Edition of the American Joint Committee on Cancer (AJCC) staging system no longer considers the mitotic count in the a or b T1 categorization for melanoma, but it adopts a sub-stratification based on the Breslow's depth. Today, the death burden of thin melanoma is still seve...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2018_170701N452
更新日期：2018-09-19 00:00:00
abstract：:Nasopharyngeal carcinoma (NPC) is a rare malignancy in the Czech Republic and Slovakia, with the standardized incidence rate of < 1:100000 person-years. Viral status of NPC in these non-endemic Eastern European regions is currently unknown. In a retrospective study, we evaluated the presence of EBV and HPV in 62 NPC c...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2016_013
更新日期：2016-01-01 00:00:00
abstract：:Puerarin has recently been demonstrated to play anti-cancer roles in a series of human cancers, including non-small cell lung cancer (NSCLC), possibly through regulation of cancer-related microRNAs (miRNAs). The purpose of the present study was to further investigate the detailed role and underlying mechanism of puera...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2020_191107N1145
更新日期：2020-11-01 00:00:00
abstract：:Few studies to date have reported on the development and application of a nanobiosensor based on localized surface plasmon resonance (LSPR) for detecting gene mutations. This study aimed to develop a novel LSPR biosensor used for detecting p53 mutation. Nanosphere lithography was used to fabricate the silver nanoparti...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2012_045
更新日期：2012-01-01 00:00:00
abstract：UNLABELLED:Survivin is highly expressed in human gastric cancer and correlated with chemoresistance and poor prognosis. In this study, we explored the effect of adeno-associated virus (AAV)-mediated survivin dominant mutant Thr34Ala (rAAV-Sur-Mut(T34A)) on gastric cancer growth. AAV-Sur-Mut (T34A) virus was generated a...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2015_010
更新日期：2015-01-01 00:00:00
abstract：:Prognostic nutritional index (PNI) is a parameter reflecting prognosis for various cancers, including resected lung cancer. However, there were few reports to study the relationship between the PNI and overall survival (OS) in patients with advanced (stage IIIB/IV) non-small lung cancer (NSCLC). In this study, we coll...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2019_190125N76
更新日期：2019-11-01 00:00:00
abstract：:The relationship between malignant tumors and blood coagulation disorders is generally well known. The authors studied blood coagulation in patients with colorectal cancer and evaluated some prothrombotic markers. The authors analyzed by latex-aglutination method, ProC Global test, Asserachrom PAI-1 test and Enzygnost...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2011_03_235
更新日期：2011-01-01 00:00:00
abstract：:The incidence of malignant tumors in children is not as high as that in adults, though in Cuba and other countries they are the most frequent causes of death in this age group. Data of the fourth triennial of the Registro Nacional del Cáncer (Cuban Cancer Registry) in the period 1973-1975 are presented. In the age gro...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:Oral cancer is one of the common cancers worldwide, among which over 90% are oral squamous cell carcinomas (OSCC). MicroRNAs act as critical regulators of cancer development and progression. MiR-103a-3p has been reported to be upregulated in OSCC patients and closely correlated to poor prognosis, yet its roles in the ...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2020_190430N382
更新日期：2020-05-01 00:00:00
abstract：:Human immediate early response 2 (IER2) has been implicated in tumor cell motility and metastasis; however, the underlying mechanisms in hepatocellular carcinoma (HCC) metastasis remain to be clarified. In this study, we demonstrate that dysregulation of IER2 was shown in HCC clinical samples, and IER2 expression resu...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2020_190818N781
更新日期：2020-05-01 00:00:00
abstract：:Chromosomal aberrations in bone marrow and lymph node cells have been investigated in 47 patients with lymphogranulomatosis 24--72 hr after administration of a single therapeutic dose of cyclophosphan and natulan. It is shown that the injurious action of cyclophosphan and natulan lasts more than 72 hr. An analysis of ...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
abstract：:The aim of the study was to evaluate the influence of the receptor status of primary breast cancer and of a number of selected clinical and morphological patient characteristics. The receptors were determined by biochemical radiocompetitive methods. Disease free survival (DFS) and overall survival (OS) were determined...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：:Using the exocolonizing test, 59Fe-utilization technique and classical cytology, the authors observed 210 days after i.v. injection of 166.7 kBq of 239Pu/kg in about 30% of contaminated mice a proliferative activity in vertebral bone marrow, characterized with high relative numbers of pluripotent hemopoietic stem cell...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:Therapeutic cells producing amphotropic retrovirus, which are able to transduce in vivo thymidine kinase gene of Herpes simplex virus were prepared. Single-cell clone cells with high virus productivity (PA-3 17JH5c113) were obtained by cell cloning. The cells were found free of replication competent retrovirus, they w...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:Very few studies have determined the prognostic value of interim and restaging PET/CT in patients with Hodgkin lymphoma using current standard of care therapy outside clinical trials. We analyzed the effect of the results of interim and restaging PET/CT on the survival (overall- and relapse-free) in patients who recei...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2015_075
更新日期：2015-01-01 00:00:00
abstract：:Tumor necrosis factor-alpha (TNF-alpha) a proinflammatory cytokine with multiple actions was first identified for its anticancer activity. However, TNF-alpha has a beneficial function in activation of host defense, its uncontrolled production can lead to pathological consequences. At the cellular level, it is able to ...
journal_title：Neoplasma
pub_type： 杂志文章,评审
doi：
更新日期：1999-01-01 00:00:00
abstract：:Molecular genetic studies have revealed mutations in a number of oncogenes and tumor suppressor genes in lung cancer. The bcl-2 gene product (bcl-2 protein) is implicated in oncogenesis by its ability to prolong cell death through the inhibition of apoptosis. We investigated expression of bcl-2 in 84 resected human no...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:Oxaliplatin is commonly used in managing malignancy, including colorectal cancer. While treatment often fails due to decreased drug sensitivity, the mechanisms involved are not clear. In this study, we investigate how exosomal miR-19b participates in oxaliplatin sensitivity and then prove that miR-19b down-regulates o...
journal_title：Neoplasma
pub_type： 杂志文章
doi：10.4149/neo_2018_180306N155
更新日期：2019-01-15 00:00:00
abstract：:Eighty-four biopsies derived from cervical tissues were analyzed for the presence of human papillomavirus (HPV) DNA types 6, 16 and 18 using Southern blot hybridization. HPV 6 was found in none of the cervical biopsies, and HPV types 16 and 18 were found in 44% of them. The rate of HPV 16/18 positive samples increased...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:The efficacy of cis-platinum in the treatment of recurrent advanced malignant melanoma is discussed and also the so far unpublished clinical data have been summed up. On account of the considerable differences among these data the clinical study of Stage II had been started which should contribute to the elucidation o...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：:Multiple ultrasonographic (USG) evaluations of abdomen were performed in 97 patients: 30 with Hodgkin's disease (HD), 60 with non-Hodgkin lymphomas (NHL) and 7 with primary gastric lymphoma (PGL) before or during chemo- or X-ray therapy. In 33% of HD patients USG was normal, while in 63% splenomegaly, in 40% hepatomeg...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:The results from our investigations concerning the secretory activity of interleukin 10 (IL-10) by two transplantable melanoma cells showed that a spontaneous alteration of the native-melanotic line into an amelanotic form and the tumor progression connected with it, were accompanied by a 6-fold decrease of the IL-10 ...
journal_title：Neoplasma
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
