Overexpression of Survivin mutant Thr34Ala induces apoptosis and inhibits gastric cancer growth.

abstract：:The influence of two kinds of transplantable melanomas on the secretory function of peritoneal macrophages, and particularly the release of TNF-alpha has been studied. The results showed a statistically significant increase of protein content in the supernatants from 24 h cultured macrophages from melanoma-bearing ham...

journal_title：Neoplasma

authors： Kozłowska K,Cichorek M

更新日期：1995-01-01 00:00:00

abstract：:Drug resistance is a prominent problem of cancer therapy. Differences in quantity and quality of many metabolites in normal and malignant cells and their changes after treatment by anticancer drugs can be detected by nuclear magnetic resonance (NMR) both in vivo and in vitro. The results of in vivo and in vitro 1H, 13...

journal_title：Neoplasma

authors： Hanusovská E,Dovinová I,Tkác I,Novotný L

更新日期：1998-01-01 00:00:00

abstract：:The effect of oxoplatinum on blastic transformation of human peripheral blood mononuclear cells (PBMC) was monitored following phytohemagglutinin (PHA) stimulation. The results were compared with those published in part III of the present work as well as with the effect of cisplatinum and carboplatinum on the blastic ...

journal_title：Neoplasma

authors： Kanková-Vancurová M,Procházková J

更新日期：1991-01-01 00:00:00

abstract：:DNA-mediated introduction of genes into mammalian cells promises to be a powerful method for detecting sequences that control cell growth, confer resistance to toxic drugs, code for surface receptor proteins, or, indeed alter cell phenotype in any clearly defined way. The identification and molecular cloning of human ...

journal_title：Neoplasma

authors： Sláviková K,Massouridou E

更新日期：1995-01-01 00:00:00

abstract：:The present study was undertaken to provide complementary information on heterochromatin condensation in central and peripheral nuclear regions during maturation of human leukemic lymphocytes using simple image processing and DNA image densitometry at the single cell level. Such approach indicated that the heterochrom...

journal_title：Neoplasma

authors： Smetana K,Karhan J,Trneny M

更新日期：2011-01-01 00:00:00

abstract：:Cancer diagnosis and treatment often produce psychologic stresses resulting from the actual symptoms of the disease, as well as from perceptions of the disease and its stigma. Depression is seen in many cancer patients. Depression occurs in approximately 25% of palliative care patients. It is widely recognised by clin...

journal_title：Neoplasma

authors： Slovacek L,Slovackova B,Slanska I,Priester P,Petera J,Kopecky J,Vanaskova J

更新日期：2009-01-01 00:00:00

abstract：:Polymorphisms in tobacco carcinogen metabolizing enzymes may generate interindividual variations towards the risk of developing prostate cancer. One of these enzymes is microsomal epoxide hydrolase (EPHX1) which metabolizes polycyclic aromatic hydrocarbons, or PAH, carcinogens found in cigarette smoke. The activity of...

journal_title：Neoplasma

authors： Sivonova MK,Dobrota D,Matakova T,Dusenka R,Grobarcikova S,Habala V,Salagovic J,Tajtakova M,Pidanicova A,Valansky L,Lachvacs L,Kliment J Jr,Nagy V,Kliment J

更新日期：2012-01-01 00:00:00

abstract：:Suppression of cell-mediated cytotoxicity directed against tumor-associated membrane antigens of methylcholanthrene (MC)-induced sarcomas by lymph node cells (LNC) from tumor-bearing mice was examined by inhibition of the 3H-thymidine incorporation assay. Normal LNC from B10 mice had been sensitized in vitro by 6-day ...

journal_title：Neoplasma

authors： Indrová M,Bubeník J

更新日期：1979-01-01 00:00:00

abstract：:GRK5 is a multifunctional protein that is able to move within the cell in response to various stimuli to regulate key intracellular signaling from receptor activation, on plasmamembrane, to gene transcription, in the nucleus. Thus, GRK5 is involved in the development and progression of several pathological conditions ...

journal_title：Neoplasma

authors： Zhao TL,Gan XX,Bao Y,Wang WP,Liu B,Wang LH

更新日期：2019-02-06 00:00:00

abstract：:The development of distant metastases is the final stage in the progression of solid cancer and is responsible for the majority of cancer-related deaths. Epithelial-mesenchymal transition (EMT) is involved in cancer progression and metastasis. In the present study we used different types of intracellular bacteria isol...

journal_title：Neoplasma

authors： Wachsmannova L,Stevurkova V,Ciernikova S

更新日期：2019-02-06 00:00:00

abstract：:Bladder cancer (BCa) is a common carcinoma of the urinary tract which occurs in the bladder mucosa. In recent years, people have recognized that epigenetic changes such as DNA methylation play important roles in the development of BCa, but the specific mechanism is unclear. In this study we detected the methylation ra...

journal_title：Neoplasma

authors： Guan H,Lu J,Qu M,Meng L,Guo Y,Li X,Shen H

更新日期：2021-01-14 00:00:00

abstract：:Monitoring of BCR-ABL transcript level is widely used in chronic myeloid leukemia (CML) to follow up response to therapy. In this study we compare abilities of two quantitative RT-PCR assays to characterize the disease status in CML patients: RT-PCR quantifying the BCR-ABL transcript concentration and RT-PCR determini...

journal_title：Neoplasma

authors： Moravcova J,Regner J,Mouckova D,Fiser K,Zmekova V,Malacova R,Michalova K,Klamova H

更新日期：2005-01-01 00:00:00

abstract：:16 colon cancer patients in the second clinical stage (according to the TNM classification), aged 34 to 71 years were studied before and 14 days after radical surgery. The in vitro cell-mediated immunity was evaluated using the rosette-forming test and blastogenic reactivity of blood lymphocytes to PHA. The percentage...

journal_title：Neoplasma

authors： Markova R,Argirova R,Boeva M

更新日期：1980-01-01 00:00:00

abstract：:Health care costs are continuously increasing. Multiple myeloma represents approximately 1% of all malignancies and the 5-year prevalence is 230,000 patients on average. In addition, there is an annual incidence of 3.8/100,000 in Slovakia. In total economic burden assessment, it is important to focus not only on direc...

journal_title：Neoplasma

authors： Babela R,Didic R,Smatana M,Fedorova K,Drgona L

更新日期：2021-01-28 00:00:00

abstract：:The aim is to present the technical feasibility and efficacy of multiple re-irradiation (re-EBRT) for local recurrence of prostate cancer (PCa) using retrospective analysis of an updated series of patients who received ablative re-EBRT with stereotactic image-guided technique for isolated local recurrence of PCa. Eigh...

journal_title：Neoplasma

authors： Volpe S,Jereczek-Fossa BA,Zerini D,Rojas DP,Fodor C,Vavassori A,Romanelli P,Vigorito S,Rondi E,Comi S,Cambria R,Cattani F,Dicuonzo S,De Marco P,Beltramo G,Musi G,De Cobelli O,Marvaso G,Orecchia R

更新日期：2019-03-05 00:00:00

abstract：:A patient with a seven-year history of polycythemia vera treated by repeated phlebotomies and intermittent busulfan administration developed gradually lymphocytosis accompanied by thrombocytopenia in peripheral blood and in the bone marrow. A marked pathological monoclonal proliferation of the B-cell population was de...

journal_title：Neoplasma

authors： Koza I,Babusíková O

更新日期：1988-01-01 00:00:00

abstract：:Projections for the incidence of all and selected major sites of cancer in the cities of Cracow and Bratislava were constructed for each year of the period 1978-1982 on the basis of data observed in the years 1968-1977. More or less increasing of unchanging trends were predicted for the malignant neoplasms of bladder,...

journal_title：Neoplasma

authors： Pawłega J,Plesko I,Dimitrova E

更新日期：1982-01-01 00:00:00

abstract：:Mammalian target of rapamycin (mTOR) has two subtypes, i.e., mTORC1 and mTORC2, which contain the Raptor and Rictor core molecules, respectively. The effect of Raptor and Rictor on hypoxia inducible factor (HIF)-1α, HIF-2α, and vascular endothelial growth factor (VEGF) in colorectal cancer (CRC) is unclear. In this wo...

journal_title：Neoplasma

authors： Wen FF,Li XY,Li YY,He S,Xu XY,Liu YH,Liu L,Wu SH

更新日期：2020-05-01 00:00:00

abstract：:The effect of a crude protein fraction from human urine having gonadotropin inhibitory activity (GGIM) was observed on the growth of 7,12-dimethylbenz(a)anthracene induced mammary tumors in Holtzman rat. Results show that while in 12 out 13 tumors, tumor growth was retarded/regressed following 2--4 weeks of CGIM treat...

journal_title：Neoplasma

authors： Sarkar S,Shah PN,Bagli NP

更新日期：1981-01-01 00:00:00

abstract：:It is generally believed that the existence of cancer stem cells (CSCs) is related to tumor recurrence and metastasis of hepatocellular carcinoma (HCC). Neuropilin1 (NRP1) is involved in numerous pathophysiological processes of tumor progression, however, whether NRP1 is involved in the regulation of liver CSCs and me...

journal_title：Neoplasma

authors： Li X,Zhou Y,Hu J,Bai Z,Meng W,Zhang L,Song X,Wei Y,Yan J,Zhou Y

更新日期：2020-12-23 00:00:00

abstract：:The growth of solid tumors and their metastasis is dependent on the development of new blood vessels (angiogenesis). In our previous studies it was found that angiogenesis inhibitor TNP-470 acting systematically can decrease the rate of growth of transplantable Bomirski Abmelanoma in hamsters. In this study we applied...

journal_title：Neoplasma

authors： Myśliwski A,Koszałka P,Bigda J,Szmit E

更新日期：2002-01-01 00:00:00

abstract：:The kinetics of tumor growth and cell proliferation of eleven generations of spontaneous mammary carcinoma in F1(CBA2 X C57B1/6) mice was studied. Factors responsible for different sensitivity of tumors to 1-methyl-1-nitrosourea were analyzed. The process of tumor transplantation was accompanied by the reduction in la...

journal_title：Neoplasma

authors： Emanuel NM,Ostrovskaya LA,Krutova TV

更新日期：1982-01-01 00:00:00

abstract：:Photodynamic therapy (PDT) has been developed in recent years as a new modality for the treatment of various neoplastic and non-neoplastic lesions. Although the method of combining light with photosensitizers for treatment has been around for a century, further understanding has been evolved over the past decades. The...

journal_title：Neoplasma

authors： Stukavec J,Horak L,Duchac V,Jirasek T,Rakusan J,Karaskova M,Pouckova P

更新日期：2008-01-01 00:00:00

abstract：:The levels of nicotinamide adenine dinucleotide (NAD) and NADH in blood of patients with cancer in various stages of development as well as their modification after glucose administration were determined in 188 respectively 77 cases. NAD was significantly decreased in patients with cervix and breast carcinoma but unal...

journal_title：Neoplasma

authors： Comes R,Mustea I

更新日期：1976-01-01 00:00:00

abstract：:Overexpressed Wilms tumor gene 1 (WT1) has been found in a majority of patients with acute myeloid leukemia (AML). The aim of this study was to confirm the applicability of WT1 expression measurement as a marker of minimal residual disease (MRD). The expression of WT1 gene was measured by real-time polymerase chain re...

journal_title：Neoplasma

authors： Polak J,Hajkova H,Haskovec C,Cechova H,Marinov I,Mikulenkova D,Markova J,Markova M,Vitek A,Valkova V

更新日期：2013-01-01 00:00:00

abstract：:An in vitro system of colony forming cell inhibition was used for evaluation of 3-oxauracil (2,3-dihydro-1,3-6H-oxazine-2,6-dione) effectivity against bone marrow cells from 18 leukemic patients. The highest inhibitive activity of the 3-oxauracil was found in cases of acute lymphoblastic leukemia, comparing with bone ...

journal_title：Neoplasma

authors： Reiner P,Mardiak J,Reinerová M,Ujházy V

更新日期：1981-01-01 00:00:00

abstract：:The isoquinoline peripheral benzodiazepine receptor ligand PK11195 increased drug (daunomycin)- and fluorochrome (calcein-AM) uptake and induced apoptosis detected by flow cytometry (FCM) technique, DNA electrophoretic analysis and poly(ADP-ribose) polymerase (PARP) cleavage in human multidrug-resistant myeloid leukem...

journal_title：Neoplasma

authors： Jakubikova J,Duraj J,Hunakova L,Chorvath B,Sedlak J

更新日期：2002-01-01 00:00:00

abstract：:Although the candidemia still remains a serious health problem, the study of candidemia in cancer patients is limited. We conducted a retrospective analysis of candidemia among 31 adult patients hospitalized in one oncological center. The mean annual incidence of candidemia was 0.14±0.05/1000 patient-days (range 0.04-...

journal_title：Neoplasma

authors： Szymankiewicz M,Nowikiewicz T

更新日期：2020-11-01 00:00:00

abstract：UNLABELLED:Solid tumors are generally composed of two major components: heterogeneous malignant cells and non-malignant stromal part. The latter comprises several types of non-malignant cells of mesenchymal, endothelial and immune origin and together with the extracellular matrix significantly affects the biological pr...

journal_title：Neoplasma

authors： Kucerova L,Skolekova S

更新日期：2013-01-01 00:00:00

abstract：:Sixty-five patients with Stage I and II endometrial carcinoma were investigated. After a short-time follow-up (17-24 months) significant differences in frequency of relapses were observed between patients with tumors containing low amounts of estrogen receptor (ER less than 60 fmol/mg DNA) in the nuclear pellet, and t...

journal_title：Neoplasma

authors： Horvath G,Johnsson JE,Tropé C,Samuelsson L,Alm P,Olsson H

更新日期：1990-01-01 00:00:00