Abstract：
:Oxaliplatin is commonly used in managing malignancy, including colorectal cancer. While treatment often fails due to decreased drug sensitivity, the mechanisms involved are not clear. In this study, we investigate how exosomal miR-19b participates in oxaliplatin sensitivity and then prove that miR-19b down-regulates oxaliplatin sensitivity of sw480 cells. We found that suppressing the secretion of exosomal miR-19b with gw4869 promotes sw480 cell oxaliplatin sensitivity. Our combined results demonstrate for the first time that miR-19b regulates the oxaliplatin sensitivity of sw480 cells and provides a unique mechanism mediated by gw4869 to modulate oxaliplatin sensitivity by suppressing exosomal miR-19b release.
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Gu YY,Yu J,Zhang JF,Wang Cdoi
10.4149/neo_2018_180306N155subject
Has Abstractpub_date
2019-01-15 00:00:00pages
39-45issue
1eissn
0028-2685issn
1338-4317pii
180306N155journal_volume
66pub_type
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