Suppressing the secretion of exosomal miR-19b by gw4869 could regulate oxaliplatin sensitivity in colorectal cancer.

Abstract:

:Oxaliplatin is commonly used in managing malignancy, including colorectal cancer. While treatment often fails due to decreased drug sensitivity, the mechanisms involved are not clear. In this study, we investigate how exosomal miR-19b participates in oxaliplatin sensitivity and then prove that miR-19b down-regulates oxaliplatin sensitivity of sw480 cells. We found that suppressing the secretion of exosomal miR-19b with gw4869 promotes sw480 cell oxaliplatin sensitivity. Our combined results demonstrate for the first time that miR-19b regulates the oxaliplatin sensitivity of sw480 cells and provides a unique mechanism mediated by gw4869 to modulate oxaliplatin sensitivity by suppressing exosomal miR-19b release.

journal_name

Neoplasma

journal_title

Neoplasma

authors

Gu YY,Yu J,Zhang JF,Wang C

doi

10.4149/neo_2018_180306N155

subject

Has Abstract

pub_date

2019-01-15 00:00:00

pages

39-45

issue

1

eissn

0028-2685

issn

1338-4317

pii

180306N155

journal_volume

66

pub_type

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